Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)

The Institut Germans Trias i Pujol (IGTP) is a CERCA centre, a public research centre devoted to the improvement of people’s health through the generation of scientific knowledge and its transfer. Recognised as an excellence centre by the Instituto de Salud Carlos III, it conveys the research activity of the Germans Trias I Pujol hospital (HUGTP). IGTP is located at the Can Ruti Campus in Badalona, where it is strongly connected with the other research institutions composing the campus: Institut Català d’Oncologia (ICO), Institut de Recerca de la Sida IrsiCaixa, Universitat Autònoma de Barcelona (UAB), Institut Guttmann, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Fundació Lluita contra la Sida (FLS), Institut de Medicina Predictiva i Personalitzada del Càncer (IMPPC), Banc de Sang i Teixits (BST) and Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT).

The research activity at IGTP covers 8 areas, producing around 500 publication per year on renowned scientific journals. The areas are: Behavioural sciences and drug abuse; Immunology and inflammation; Heart, vascular and respiratory diseases; Infectious diseases; Endocrine-metabolic, bone and renal diseases; Liver and digestive system; Cancer; Neurosciences. Moreover the institute has several technological facilities providing essential support to the researchers.

Latest additions:
2017-05-22
15:15
12 p, 237.9 KB Impact of Obstructive Sleep Apnea on the Levels of Placental Growth Factor (PlGF) and Their Value for Predicting Short-Term Adverse Outcomes in Patients with Acute Coronary Syndrome / Barcelo, Antonia (Hospital Universitari Son Espases (Illes Balears)) ; Bauça, Josep Miquel (Hospital Universitari Son Espases (Illes Balears)) ; Yañez, Ayna (Hospital Universitari Son Espases (Illes Balears)) ; Abad, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Spanish Sleep Group
BACKGROUND: Placental growth factor (PlGF) induces angiogenesis and promotes tissue repair, and plasma PlGF levels change markedly during acute myocardial infarction (AMI). Currently, the impact of obstructive sleep apnea (OSA) in patients with AMI is a subject of debate. [...]
2016 - 10.1371/journal.pone.0147686
PloS one, Vol. 11 Núm. 3 (March 2016)  
2017-05-22
15:09
10 p, 356.7 KB Low Insulin-Like Growth Factor-1 Level in Obesity Nephropathy: A New Risk Factor? / Bancu, Ioana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Navarro Díaz, Maruja (REDinREN (Madrid)) ; Serra, Assumpta (REDinREN (Madrid)) ; Granada, Marisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; López, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Romero González, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bonet, Josep (REDinREN (Madrid))
INTRODUCTION: IGF-1 (insulin-like growth factor-1) is a hormone involved in cell growth and other important processes. In the kidney, IGF-1 has a stimulating effect, increasing the blood flow and glomerular filtration rate. [...]
2016 - :10.1371/journal.pone.0154451
PloS one, Vol. 11 Núm. 5 (May 2016)  
2017-05-18
17:14
16 p, 4.7 MB The Progress of Therapeutic Vaccination with Regard to Tuberculosis / Cardona, Pere-Joan (Institut Germans Trias i Pujol)
A major problem with tuberculosis (TB) control is the long duration of drug therapy-both for latent and for active TB. Therapeutic vaccination has been postulated to improve this situation, and to this end there are several candidates already in clinical phases of development. [...]
- 10.3389/fmicb.2016.01536
Frontiers in microbiology, Vol. 7 Núm. 11536 (September 2016)  
2017-05-18
17:00
18 p, 9.9 MB The Small Breathing Amplitude at the Upper Lobes Favors the Attraction of Polymorphonuclear Neutrophils to Mycobacterium tuberculosis Lesions and Helps to Understand the Evolution toward Active Disease in An Individual-Based Model / Cardona, Pere-Joan (Institut Germans Trias i Pujol) ; Prats, Clara (Universitat Politècnica de Catalunya. Escola Superior d'Agricultura de Barcelona)
Infection with Mycobacterium tuberculosis (Mtb) can induce two kinds of lesions, namely proliferative and exudative. The former are based on the presence of macrophages with controlled induction of intragranulomatous necrosis, and are even able to stop its physical progression, thus avoiding the induction of active tuberculosis (TB). [...]
- 10.3389/fmicb.2016.00354
Frontiers in microbiology, Vol. 7 Núm. 654 (March 2016)  
2016-11-11
11:19
12 p, 7.8 MB Alcohol Consumption during Pregnancy : Analysis of Two Direct Metabolites of Ethanol in Meconium / Sanvisens, Arantza (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Robert, Neus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Hernández Pérez, José María (Institut Germans Trias i Pujol) ; Zuluaga, Paola (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Farré Albaladejo, Magí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Coroleu, Wifredo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Serra Landete, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Tor Aguilera, J. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Muga Bustamante, Robert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Alcohol consumption in young women is a widespread habit that may continue during pregnancy and induce alterations in the fetus. We aimed to characterize prevalence of alcohol consumption in parturient women and to assess fetal ethanol exposure in their newborns by analyzing two direct metabolites of ethanol in meconium. [...]
2016 - 10.3390/ijms17030417
International Journal of Molecular Sciences, Vol. 17 Núm. 3 (March 2016)  
2016-07-26
20:15
12 p, 942.4 KB BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer / Karachaliou, Niki (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ; Codony-Servat, Jordi (Pangaea Biotech (Barcelona, Catalunya)) ; Teixidó, Cristina (Pangaea Biotech (Barcelona, Catalunya)) ; Pilotto, Sara (University of Verona (Itàlia)) ; Drozdowskyj, Ana (Pivotal (Madrid)) ; Codony-Servat, Carles (Pangaea Biotech (Barcelona, Catalunya)) ; Giménez-Capitán, Ana (Pangaea Biotech (Barcelona, Catalunya)) ; Molina-Vila, Miguel Ángel (Pangaea Biotech (Barcelona, Catalunya)) ; Bertrán-Alamillo, Jordi (Pangaea Biotech (Barcelona, Catalunya)) ; Gervais, Radj (Centre François Baclesse (Caen, França)) ; Massuti, Bartomeu (Hospital General de Alicante) ; Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Majem, Margarita (Hospital de Sant Pau (Barcelona, Catalunya)) ; Felip Font, Enriqueta (Hospital Vall d'Hebron (Barcelona, Catalunya)) ; Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña) ; Viteri, Santiago (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ; González-Cao, María (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ; Morales-Espinosa, Daniela (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ; Verlicchi, Alberto (Ospedale Santa Maria delle Croci (Ravenna, Itàlia)) ; Crisetti, Elisabetta (Institute of Respiratory Diseases. University of Foggia (Itàlia)) ; Chaib, Imane (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Santarpia, Mariacarmela (Human Pathology Department. University of Messina (Itàlia)) ; Ramírez, José Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bosch-Barrera, Joaquim (Hospital Josep Trueta, Girona. Institut Català d'Oncologia) ; Cardona Zorrilla, Andrés Felipe (Instituto de Oncología de Clínica del Country (Bogotá, Colòmbia)) ; De Marinis, Filippo (Istituto Europeo di Oncologia (Milà, Itàlia)) ; López-Vivanco, Guillermo (Hospital de Cruces (Barakaldo, Biscaia)) ; Sánchez, José Miguel (Hospital Universitario de la Princesa (Madrid)) ; Vergnenegre, Alain (Hôpital du Cluzeau (Limoges, França)) ; Sánchez Hernández, José Javier (Universidad Autónoma de Nuevo León (Mèxic)) ; Sperduti, Isabella (Istituto Regina Elena Cancer Institute (Roma, Itàlia)) ; Bria, Emilio (University of Verona (Itàlia)) ; Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Abstract. BIM is a proapoptotic protein that initiates apoptosis triggered by EGFR tyrosine kinase inhibitors (TKI). mTOR negatively regulates apoptosis and may influence response to EGFR TKI. We examined mRNA expression of BIM and MTOR in 57 patients with EGFR-mutant NSCLC from the EURTAC trial. [...]
2015 - 10.1038/srep17499
Scientific reports, Vol. 7 (December 2015)  
2016-07-26
20:05
12 p, 735.8 KB The small RNA content of human sperm reveals pseudogene-derived piRNAs complementary to protein-coding genes / Pantano, Lorena (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Jodar, Meritxell (Universitat de Barcelona. Departament de Ciències Fisiològiques) ; Bak, Mads (University of Copenhagen (Dinamarca)) ; Ballescà, Josep Lluís (Hospital Clínic i Provincial de Barcelona) ; Tommerup, Niels (University of Copenhagen (Dinamarca)) ; Oliva, Rafael (Hospital Clínic i Provincial de Barcelona) ; Vavouri, Tanya (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Abstract. At the end of mammalian sperm development, sperm cells expel most of their cytoplasm and dispose of the majority of their RNA. Yet, hundreds of RNA molecules remain in mature sperm. The biological significance of the vast majority of these molecules is unclear. [...]
2015 - 10.1261/rna.046482.114
RNA, Vol. 21 Núm. 6 (June 2015)  
2016-07-26
19:56
5 p, 846.7 KB Variants in the CYP7B1 gene region do not affect natural resistance to HIV-1 infection / Sironi, Manuela (San Raffaele Scientific Institute (Milà, Itàlia)) ; Biasin, Mara (University of Milan (Itàlia)) ; Pontremoli, Chiara (San Raffaele Scientific Institute (Milà, Itàlia)) ; Cagliani, Rachele (San Raffaele Scientific Institute (Milà, Itàlia)) ; Saulle, Irma (University of Milan (Itàlia)) ; Trabattoni, Daria (University of Milan (Itàlia)) ; Vichi, Francesca (Santa Maria Annunziata Hospital (Florència, Itàlia)) ; Lo Caputo, Sergio (Santa Maria Annunziata Hospital (Florència, Itàlia)) ; Mazzotta, Francesco (Santa Maria Annunziata Hospital (Florència, Itàlia)) ; Aguilar-Jimenez, Wbeimar (Universidad de Antioquia (Medellín, Colòmbia)) ; Rugeles, María Teresa (Universidad de Antioquia (Medellín, Colòmbia)) ; Cedeno, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Sanchez, Jorge (Asociación Civil Impacta Salud y Educación (Lima, Perú)) ; Brander, Christian (Universitat de Vic) ; Clerici, Mario (Foundation ONLUS (Milà, Itàlia)) ; Universitat Autònoma de Barcelona
Abstract. BACKGROUND: The genetic bases of natural resistance to HIV-1 infection remain largely unknown. Recently, two genome-wide association studies suggested a role for variants within or in the vicinity of the CYP7B1 gene in modulating HIV susceptibility. [...]
2015 - 10.1186/s12977-015-0206-0
Retrovirology, Vol. 12 Núm. 80 (september 2015)  
2016-07-26
19:22
15 p, 3.1 MB HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells / Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erikson, Elina (University of Frankfurt (Alemanya)) ; Fernández Figueras, Maria Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rausell, Antonio (University of Lausanne (Suïssa)) ; Ciuffi, Angela (University of Lausanne (Suïssa)) ; Keppler, Oliver T. (University of Frankfurt (Alemanya)) ; Telenti, Amalio (University of Lausanne (Suïssa)) ; Kräusslich, Hans-Georg (University of Heidelberg (Alemanya)) ; Martínez Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. [...]
2015 - 10.1186/s12977-015-0160-x
Retrovirology, Vol 12, article 37 (May 2015)  
2016-07-26
19:13
26 p, 2.7 MB Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection / Adland, Emily (University of Oxford) ; Paioni, Paolo (University of Oxford) ; Thobakgale, Christina (University of KwaZulu-Natal (Durban, Sud-àfrica)) ; Laker, Leana (Kimberley Hospital (Northern Cape, Sud-àfrica)) ; Mori, Luisa (Kimberley Hospital (Northern Cape, Sud-àfrica)) ; Muenchhoff, Maximilian (University of Oxford) ; Csala, Anna (University of Oxford) ; Clapson, Margaret (Saint Hospital for Children (London, Gran Bretanya)) ; Flynn, Jacquie (Saint Hospital for Children (London, Gran Bretanya)) ; Novelli, Vas (Saint Hospital for Children (London, Gran Bretanya)) ; Hurst, Jacob (University of Oxford) ; Naidoo, Vanessa (University of KwaZulu-Natal (Durban, Sud-àfrica)) ; Shapiro, Roger (Botswana Harvard AIDS Institute Partnership (Gaborone, Botswana)) ; Gary, Kuan-Hsiang Huang (University of Oxford) ; Frater, John (University of Oxford) ; Prendergast, Andrew (Queen Mary University of London) ; Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ndung'u, Thumbi (University of KwaZulu-Natal (Durban, Sud-àfrica)) ; Walker, Bruce D. (University of Oxford) ; Carrington, Mary (National Cancer Institute (Maryland, Estats Units d'Amèrica)) ; Jooste, Pieter (Kimberley Hospital (Northern Cape, Sud-àfrica)) ; Goulder, Philip J. R. (University of Oxford)
Abstract. HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted CD8+ T-cell responses. [...]
2015 - 10.1371/journal.ppat.1004954
PLoS pathogens, Vol. 11 Núm. 6 (June 2015)