Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)

The Institut Germans Trias i Pujol (IGTP) is a CERCA centre, a public research centre devoted to the improvement of people’s health through the generation of scientific knowledge and its transfer. Recognised as an excellence centre by the Instituto de Salud Carlos III, it conveys the research activity of the Germans Trias I Pujol hospital (HUGTP). IGTP is located at the Can Ruti Campus in Badalona, where it is strongly connected with the other research institutions composing the campus: Institut Català d’Oncologia (ICO), Institut de Recerca de la Sida IrsiCaixa, Universitat Autònoma de Barcelona (UAB), Institut Guttmann, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Fundació Lluita contra la Sida (FLS), Institut de Medicina Predictiva i Personalitzada del Càncer (IMPPC), Banc de Sang i Teixits (BST) and Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT).

The research activity at IGTP covers 8 areas, producing around 500 publication per year on renowned scientific journals. The areas are: Behavioural sciences and drug abuse; Immunology and inflammation; Heart, vascular and respiratory diseases; Infectious diseases; Endocrine-metabolic, bone and renal diseases; Liver and digestive system; Cancer; Neurosciences. Moreover the institute has several technological facilities providing essential support to the researchers.

Latest additions:
2017-05-22
19:41
10 p, 1.4 MB Serum-derived exosomes from non-viremic animals previously exposed to the porcine respiratory and reproductive virus contain antigenic viral proteins / Montaner-Tarbes, Sergio (Universitat de Lleida. Departament de Producció Animal) ; Borrás, Francesc E. (Innovex Therapeutics) ; Montoya, Maria (The Pirbright Institute (Regne Unit)) ; Fraile, Lorenzo (Universitat de Lleida. Departament de Producció Animal) ; Portillo Obando, Hernando A. del (Institut Germans Trias i Pujol)
PRRSV is the etiological agent of one of the most important swine diseases with a significant economic burden worldwide and limitations in vaccinology. Exosomes are 30-100 nm vesicles of endocytic origin. [...]
2016
Veterinary research, Vol. 47 Núm. 1 (May 2016) , p. 59  
2017-05-22
19:37
Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency / Muñoz López, Álvaro (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras) ; Romero Moya, Damià (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras) ; Prieto, Cristina (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras) ; Ramos Mejía, Verónica (Centro Pfizer - Universidad de Granada - Junta de Andalucía de Genómica e Investigación Oncológica) ; Agraz Doblas, Antonio (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras) ; Varela, Ignacio (Instituto de Biomedicina y Biotecnología de Cantabria) ; Buschbeck, Marcus (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras) ; Palau, Anna (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras) ; Carvajal Vergara, Xonia (Universidad de Navarra. Centro de Investigación Médica Aplicada) ; Giorgetti, Alessandra (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras) ; Ford, Anthony (Institute of Cancer Research (London, Gran Bretanya)) ; Lako, Majlinda (Newcastle University. Institute of Genetic Medicine) ; Granada, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ruiz Xivillé, Neus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez Perales, Sandra (Centro Nacional de Investigaciones Oncológicas) ; Torres Ruíz, Raúl (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras) ; Stam, Ronald W. (Erasmus University Medical Center (Rotterdam, Holanda)) ; Fuster, José Luis (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ; Fraga, Mario F. (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ; Nakanishi, Mahito (National Institute of Advanced Industrial Science and Technology (Tsukuba, Japó)) ; Cazzaniga, Gianni (Università degli Studi di Milano-Bicocca) ; Bardini, Michela (Università degli Studi di Milano-Bicocca) ; Cobo, Isabel (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras) ; Bayón, Gustavo F. (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ; Fernández, Agustín F. (Instituto Universitario de Oncología del Principado de Asturias (Oviedo)) ; Bueno, Clara (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras) ; Menéndez, Pablo (Universitat de Barcelona (Campus Clínic). Institut de Recerca contra la Leucèmia Josep Carreras)
Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages. [...]
- 10.1016/j.stemcr.2016.08.013
Stem cell reports, Vol. 7 Núm. 4 (October 2016)  
2017-05-22
19:29
9 p, 1.4 MB Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles' characteristics compared to precipitating agents / Gámez Valero, Ana (Institut Germans Trias i Pujol) ; Monguió Tortajada, Marta (Institut Germans Trias i Pujol) ; Carreras Planella, Laura (Institut Germans Trias i Pujol) ; Franquesa, Marcel·la (Institut Germans Trias i Pujol) ; Beyer, Katrin (Institut Germans Trias i Pujol) ; Borràs, Francesc E. (Institut Germans Trias i Pujol)
Extracellular vesicles (EVs) have become an attractive field among the scientific community. Yet, a major challenge is to define a consensus method for EVs isolation. Ultracentrifugation has been the most widely used methodology but rapid methods, including Size Exclusion Chromatography (SEC) and/or precipitating agents such as Polyethylene glycol (PEG) or PRotein Organic Solvent PRecipitation (PROSPR) have emerged. [...]
2016 - 10.1038/srep33641
Scientific reports, Vol. 6 (September 2016)  
2017-05-22
17:35
14 p, 1.7 MB Attentional Selection Accompanied by Eye Vergence as Revealed by Event-Related Brain Potentials / Sole Puig, Maria (Universitat de Barcelona. Departament de Cognició, Desenvolupament i Psicologia de l'Educació) ; Pallarés, Josep Marco (Universitat de Barcelona. Departament de Cognició, Desenvolupament i Psicologia de l'Educació) ; Perez Zapata, Laura (Universitat de Barcelona. Departament de Cognició, Desenvolupament i Psicologia de l'Educació) ; Puigcerver, Laura (Universitat de Barcelona. Institut de Neurociències) ; Cañete, Josep (Consorci Sanitari del Maresme. Salut Mental i Addiccions) ; Supèr, Hans (Universitat de Barcelona. Departament de Cognició, Desenvolupament i Psicologia de l'Educació)
Neural mechanisms of attention allow selective sensory information processing. Top-down deployment of visual-spatial attention is conveyed by cortical feedback connections from frontal regions to lower sensory areas modulating late stimulus responses. [...]
2016 - 10.1371/journal.pone.0167646
PloS one, Vol. 11 Núm. 12 (December 2016)  
2017-05-22
15:41
21 p, 578.4 KB Use of H-Index and other bibliometric indicators to evaluate research productivity outcome on swine diseases / Díaz, Ivan (Fundació Centre de Recerca en Sanitat Animal) ; Cortey, Martí (Fundació Centre de Recerca en Sanitat Animal) ; Olvera, Àlex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Segalés Coma, Joaquim (Fundació Centre de Recerca en Sanitat Animal) ; Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals
H-index is the most commonly applied tool to evaluate scientific productivity. In this study, the use of the H-index to evaluate scientific production in swine veterinary medicine was explored. A database of 137 pig infectious agents was constructed, including its taxonomic division, zoonotic potential, status as emerging pathogen and whether it was OIE-listed. [...]
2016 - 10.1371/journal.pone.0149690
PloS One, Vol. 11, Núm. 3 (March 2016) , e0149690  
2017-05-22
15:21
19 p, 1.2 MB Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naïve HIV-Infected Individuals / Blanco Heredia, Juan (Instituto Nacional de Enfermedades Respiratorias (México)) ; Lecanda, Aarón (Instituto Nacional de Enfermedades Respiratorias (México)) ; Valenzuela Ponce, Humberto (Instituto Nacional de Enfermedades Respiratorias (México)) ; Brander Silva, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ávila Ríos, Santiago (Instituto Nacional de Enfermedades Respiratorias (México)) ; Reyes Terán, Gustavo (Instituto Nacional de Enfermedades Respiratorias (México))
Background: therapeutic HIV vaccines may prove helpful to intensify antiretroviral treatment (ART) efficacy and may be an integral part of future cure strategies. Methods: we examined IFN-gamma ELISpot responses to a panel of 218 HIV clade B consensus-based HIV protease-reverse transcriptase peptides, designed to mimic previously described and predicted cytotoxic T lymphocyte epitopes overlapping drug resistance (DR) positions, that either included the consensus sequence or the DR variant sequence, in 49 ART-naïve HIV-infected individuals. [...]
2016 - 10.1371/journal.pone.0147571
PloS one, Vol. 11 Núm. 1 (January 2016)  
2017-05-22
15:15
12 p, 237.9 KB Impact of Obstructive Sleep Apnea on the Levels of Placental Growth Factor (PlGF) and Their Value for Predicting Short-Term Adverse Outcomes in Patients with Acute Coronary Syndrome / Barcelo, Antonia (Hospital Universitari Son Espases (Illes Balears)) ; Bauça, Josep Miquel (Hospital Universitari Son Espases (Illes Balears)) ; Yañez, Ayna (Hospital Universitari Son Espases (Illes Balears)) ; Abad, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Spanish Sleep Group
BACKGROUND: Placental growth factor (PlGF) induces angiogenesis and promotes tissue repair, and plasma PlGF levels change markedly during acute myocardial infarction (AMI). Currently, the impact of obstructive sleep apnea (OSA) in patients with AMI is a subject of debate. [...]
2016 - 10.1371/journal.pone.0147686
PloS one, Vol. 11 Núm. 3 (March 2016)  
2017-05-22
15:09
10 p, 356.7 KB Low Insulin-Like Growth Factor-1 Level in Obesity Nephropathy: A New Risk Factor? / Bancu, Ioana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Navarro Díaz, Maruja (REDinREN (Madrid)) ; Serra, Assumpta (REDinREN (Madrid)) ; Granada, Marisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; López, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Romero González, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bonet, Josep (REDinREN (Madrid))
INTRODUCTION: IGF-1 (insulin-like growth factor-1) is a hormone involved in cell growth and other important processes. In the kidney, IGF-1 has a stimulating effect, increasing the blood flow and glomerular filtration rate. [...]
2016 - :10.1371/journal.pone.0154451
PloS one, Vol. 11 Núm. 5 (May 2016)  
2017-05-19
19:16
12 p, 1.1 MB The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites / De Niz, Mariana (University of Bern (Suïssa)) ; Ullrich, Ann-Katrin (Bernhard-Nocht-Institut für Tropenmedizin) ; Heiber, Arlett (Bernhard-Nocht-Institut für Tropenmedizin) ; Blancke Soares, Alexandra (Bernhard-Nocht-Institut für Tropenmedizin) ; Pick, Christian (Universität Hamburg) ; Lyck, Ruth (University of Bern (Suïssa)) ; Keller, Derya (University of Bern (Suïssa)) ; Kaiser, Gesine (University of Bern (Suïssa)) ; Prado, Monica (Bernhard-Nocht-Institut für Tropenmedizin) ; Flemming, Sven (Bernhard-Nocht-Institut für Tropenmedizin) ; Portillo Obando, Hernando A. del (Institut Germans Trias i Pujol) ; Janse, Chris J. (Leiden University Medical Center (Leiden, Països Baixos) ; Heussler, Volker T. (University of Bern (Suïssa)) ; Spielmann, Tobias (Bernhard-Nocht-Institut für Tropenmedizin)
Sequestration of red blood cells infected with the human malaria parasite Plasmodium falciparum in organs such as the brain is considered important for pathogenicity. A similar phenomenon has been observed in mouse models of malaria, using the rodent parasite Plasmodium berghei, but it is unclear whether the P. [...]
2016 - 10.1038/ncomms11659
Nature communications, Vol. 7 (May 2016) , article 11659  
2017-05-19
18:35
11 p, 1.5 MB Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients / Mansilla López, Mª José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Contreras-Cardone, Raian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cools, Nathalie (University of Antwerp. Vaccine & Infectious Disease Institute) ; Berneman,Zwi (University of Antwerp. Vaccine & Infectious Disease Institute) ; Ramo Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
BACKGROUND: Tolerogenic dendritic cells (tolDC) have been postulated as a potent immunoregulatory therapy for autoimmune diseases such as multiple sclerosis (MS). In a previous study, we demonstrated that the administration of antigen-specific vitamin D3 (vitD3) tolDC in mice showing clinical signs of experimental autoimmune encephalomyelitis (EAE; the animal model of MS) resulted in abrogation of disease progression. [...]
2016 - 10.1186/s12974-016-0584-9
Journal of Neuroinflammation, Vol. 13, No. 113 (May 2016)