Per citar aquest document: http://ddd.uab.cat/record/109303
Task-induced deactivation from rest extends beyond the default mode brain network
Harrison, Ben J. (Parc de Recerca Biomèdica de Barcelona (PRBB). Institut d’Alta Tecnologia)
Pujol Nuez, Jesús (Parc de Recerca Biomèdica de Barcelona (PRBB). Institut d’Alta Tecnologia)
Contreras-Rodríguez, Oren (Parc de Recerca Biomèdica de Barcelona (PRBB). Institut d’Alta Tecnologia)
Soriano Mas, Carles (Parc de Recerca Biomèdica de Barcelona (PRBB). Institut d’Alta Tecnologia)
López Solà, Marina (Parc de Recerca Biomèdica de Barcelona (PRBB). Institut d’Alta Tecnologia)
Deus Yela, Juan (Parc de Recerca Biomèdica de Barcelona (PRBB). Institut d’Alta Tecnologia)
Ortiz Valencia, Héctor (Parc de Recerca Biomèdica de Barcelona (PRBB). Institut d’Alta Tecnologia)
Blanco Hinojo, Laura (Parc de Recerca Biomèdica de Barcelona (PRBB). Institut d’Alta Tecnologia)
Alonso, Pino (Hospital de Bellvitge. Departament de Psiquiatría)
Hernández Ribas, Rosa (Hospital de Bellvitge. Departament de Psiquiatría)
Cardoner, Narcís (Hospital de Bellvitge. Departament de Psiquiatría)
Menchón Magriñá, José Manuel (Hospital de Bellvitge. Departament de Psiquiatría)

Data: 2011
Resum: Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized ‘default-mode network’ (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; publishedVersion
Matèria: Neurologia ; Cervell ; Regiones cerebrales ; Brain regions
Publicat a: PLoS one, Vol. 6, Issue 7 (July 2011) , p. e22964, ISSN 1932-6203

DOI: 10.1371/journal.pone.0022964


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