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Not all stressors are equal : behavioral and endocrine evidence for development of contextual fear conditioning after a single session of footshocks but not of immobilization
Daviu Abant, Núria (Universitat Autònoma de Barcelona. Institut de Neurociències)
Raúl Delgado-Morales (Universitat Autònoma de Barcelona. Institut de Neurociències)
Armario García, Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Nadal i Alemany, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)

Data: 2012
Resum: Exposure of animals to footshocks (FS) in absence of any specific cue results in the development of fear to the compartment where shocks were given (contextual fear conditioning), and this is usually evaluated by time spent freezing. However, the extent to which contextual fear conditioning always develops when animals are exposed to other stressors is not known. In the present work we firstly demonstrated, using freezing, that exposure of adult rats to a single session of FS resulted in short-term and long-term contextual fear conditioning (freezing) that was paralleled by increased hypothalamic-pituitary-adrenal (HPA) activation. In contrast, using a similar design, no HPA or behavioral evidence for such conditioning was found after exposure to immobilization on boards (IMO), despite this stressor being of similar severity as FS on the basis of standard physiological measures of stress, including HPA activation. In a final experiment we directly compared the exposure to the two stressors in the same type of context and tested for the development of conditioning to the context and to a specific cue for IMO (the board). We observed the expected high levels of freezing and the conditioned HPA activation after FS, but not after IMO, regardless of the presence of the board during testing. Therefore, it can be concluded that development of fear conditioning to context or particular cues, as evaluated by either behavioral or endocrine measures, appears to be dependent on the nature of the aversive stimuli, likely to be related to biologically preparedness to establish specific associations.
Nota: Número d'acord de subvenció MICINN/SAF2/008-01175
Nota: Número d'acord de subvenció MICINN/SAF2/011-28313
Nota: Número d'acord de subvenció AGAUR/SGR/009-16
Nota: Número d'acord de subvenció RD06/0001-0015
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Matèria: Contextual fear conditioning ; Hypothalamic-pituitary-adrenal axis ; Stress ; Footshock ; Immobilization ; Freezing
Publicat a: Frontiers in behavioral neuroscience, Núm. 29 (2012) , p. 1-14, ISSN 1662-5153

DOI: 10.3389/fnbeh.2012.00069

14 p, 2.0 MB

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 Registre creat el 2013-07-25, darrera modificació el 2016-10-03

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