Per citar aquest document: http://ddd.uab.cat/record/112459
A bi-dimensional genome scan for prolificacy traits in pigs shows the existence of multiple epistatic QTL
Noguera Jiménez, José Luis (Institut de Recerca i Tecnologia Agroalimentàries)
Rodríguez, Carmen (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria)
Varona Aguado, Luis (Institut de Recerca i Tecnologia Agroalimentàries)
Tomás Sangenís, Anna (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Muñoz, Gloria (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria)
Ramírez Bellido, Óscar (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Barragán, Carmen (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria)
Arqué, Meritxell (Institut de Recerca i Tecnologia Agroalimentàries)
Bidanel, Jean P. (Institut national de la recherche agronomique (França))
Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Ovilo, Cristina (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria)
Sánchez Bonastre, Armando (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Data: 2009
Resum: Background: Prolificacy is the most important trait influencing the reproductive efficiency of pig production systems. The low heritability and sex-limited expression of prolificacy have hindered to some extent the improvement of this trait through artificial selection. Moreover, the relative contributions of additive, dominant and epistatic QTL to the genetic variance of pig prolificacy remain to be defined. In this work, we have undertaken this issue by performing one-dimensional and bi-dimensional genome scans for number of piglets born alive (NBA) and total number of piglets born (TNB) in a three generation Iberian by Meishan F2 intercross. Results: The one-dimensional genome scan for NBA and TNB revealed the existence of two genome-wide highly significant QTL located on SSC13 (P < 0. 001) and SSC17 (P < 0. 01) with effects on both traits. This relative paucity of significant results contrasted very strongly with the wide array of highly significant epistatic QTL that emerged in the bi-dimensional genome-wide scan analysis. As much as 18 epistatic QTL were found for NBA (four at P < 0. 01 and five at P < 0. 05) and TNB (three at P < 0. 01 and six at P < 0. 05), respectively. These epistatic QTL were distributed in multiple genomic regions, which covered 13 of the 18 pig autosomes, and they had small individual effects that ranged between 3 to 4% of the phenotypic variance. Different patterns of interactions (a × a, a × d, d × a and d × d) were found amongst the epistatic QTL pairs identified in the current work. Conclusions: The complex inheritance of prolificacy traits in pigs has been evidenced by identifying multiple additive (SSC13 and SSC17), dominant and epistatic QTL in an Iberian × Meishan F2 intercross. Our results demonstrate that a significant fraction of the phenotypic variance of swine prolificacy traits can be attributed to first-order gene-by-gene interactions emphasizing that the phenotypic effects of alleles might be strongly modulated by the genetic background where they segregate.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; publishedVersion
Publicat a: BMC Genomics, Vol. 10, N. 636 (December 2009) , p. 1-12, ISSN 1471-2164



12 p, 345.1 KB

El registre apareix a les col·leccions:
Articles > Articles publicats

 Registre creat el 2013-10-07, darrera modificació el 2016-07-06



   Favorit i Compartir