Per citar aquest document: http://ddd.uab.cat/record/112510
Evaluation of C-reactive protein, Haptoglobin and cardiac Troponin 1 levels in brachycephalic dogs with upper airway obstructive syndrome.
Planellas, Marta (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Cuenca Valera, Rafaela (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Tabar Rodríguez, María Dolores (Centro Policlínico Veterinario Raspeig (Alacant, País Valencià))
Bertolani, Coralie (Centre Hospitalier Vétérinaire Frégis (Arcueil, França))
Poncet, Cyrill (Centre Hospitalier Vétérinaire Frégis (Arcueil, França))
Closa, Josep M. (Hospital ARS Veterinària (Cardedeu, Catalunya))
Lorente Guerrero, Juan (Vall d'Hebron Hospitals)
Cerón, José Joaquín (Universidad de Murcia. Departamento de Medicina y Cirugía Animal)
Pastor Milan, Josep (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Data: 2012
Resum: Background: Brachycephalic dogs have unique upper respiratory anatomy with abnormal breathing patterns similar to those in humans with obstructive sleep apnea syndrome (OSAS). The objective of this study was to evaluate the correlation between anatomical components, clinical signs and several biomarkers, used to determine systemic inflammation and myocardial damage (C-reactive protein, CRP; Haptoglobin, Hp; cardiac troponin I, cTnI), in dogs with brachycephalic upper airway obstructive syndrome (BAOS). Results: Fifty brachycephalic dogs were included in the study and the following information was studied: signalment, clinical signs, thoracic radiographs, blood work, ECG, components of BAOS, and CRP, Hp and cTnI levels. A high proportion of dogs with BAOS (88%) had gastrointestinal signs. The prevalence of anatomic components of BAOS was: elongated soft palate (100%), stenotic nares (96%), everted laryngeal saccules (32%) and tracheal hypoplasia (29. 1%). Increased serum levels of biomarkers were found in a variable proportion of dogs: 14% (7/50) had values of CRP > 20 mg/L, 22. 9% (11/48) had values of Hp > 3 g/L and 47. 8% (22/46) had levels of cTnI > 0. 05 ng/dl. Dogs with everted laryngeal saccules had more severe respiratory signs (p<0. 02) and higher values of CRP (p<0. 044). No other statistical association between biomarkers levels and severity of clinical signs was found. Conclusions: According to the low percentage of patients with elevated levels of CRP and Hp, BAOS does not seem to cause an evident systemic inflammatory status. Some degree of myocardial damage may occur in dogs with BAOS that can be detected by cTnI concentration.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; publishedVersion
Matèria: Acute phase proteins ; Apnea ; Brachycephalic ; Hypoxia ; Myocardial damage ; Upper airway
Publicat a: BMC Veterinary research, Vol. 8, N. 152 (August 2012) , p. 1-7, ISSN 1746-6148

DOI: 10.1186/1746-6148-8-152


7 p, 183.8 KB

El registre apareix a les col·leccions:
Articles > Articles publicats

 Registre creat el 2013-10-09, darrera modificació el 2016-10-03



   Favorit i Compartir