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Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans
Fagundo Morales, Ana Beatriz (Hospital de Bellvitge. Departament de Psiquiatria)
de la Torre, Rafael (Instituto de Salud "Carlos III")
Jiménez Murcia, Susana (Hospital de Bellvitge. Departament de Psiquiatria)
Agüera, Zaida (Instituto de Salud "Carlos III")
Pastor, Antoni (Hospital del Mar (Barcelona, Catalunya))
Casanueva, Felipe F. (Instituto de Salud "Carlos III")
Granero, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i Metodologia)
Baños, Rosa (Instituto de Salud "Carlos III")
Botella, Cristina (Instituto de Salud "Carlos III")
Pino Gutiérrez, Amparo del (Hospital de Bellvitge. Departament de Psiquiatria)
Fernández Real, Jose M. (Instituto de Salud "Carlos III")
Fernández García, Jose C. (Instituto de Salud "Carlos III")
Frühbeck, Gema (Instituto de Salud "Carlos III")
Gómez Ambrosi, Javier (Instituto de Salud "Carlos III")
Menchón Magriñá, José Manuel (Hospital de Bellvitge. Departament de Psiquiatria)
Moragrega, Inés (Instituto de Salud "Carlos III")
Rodríguez, Roser (Instituto de Salud "Carlos III")
Tárrega Larrea, Salomé (Universitat Autònoma de Barcelona. Departament de Psicobiologia i Metodologia)
Tinahones, Francisco J. (Instituto de Salud "Carlos III")
Fernández Aranda, Fernando (Hospital de Bellvitge. Departament de Psiquiatria)

Data: 2013
Resum: Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −. 37; p<. 05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = . 59; p<. 05) and decision making performance (r = . 23; P<. 05). There was no significant correlation between either 2-AG (r = −. 17) or AEA (r = −. 08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; publishedVersion
Matèria: Animal behavior ; Prefrontal cortex ; Endocannabinoids ; Cognition ; Cannabis
Publicat a: PLoS one, Vol. 8, Issue 6 (June 2013) , p.e66387, ISSN 1932-6203

DOI: 10.1371/journal.pone.0066387
PMID: 23840456

7 p, 165.9 KB

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