Per citar aquest document: http://ddd.uab.cat/record/112622
Potassium starvation in yeast : mechanisms of homeostasis revealed by mathematical modeling
Kahm, Matthias (University of Applied Sciences. Department of Mathematics and Technology (Koblenz, Alemanya))
Navarrete, Clara (Universidad de Córdoba. Departmento de Microbiologia)
Llopis Torregrosa, Vicent (Instituto de Biologia Molecular y Celular de Plantas (València, Espanya))
Herrera, Rito (Universidad de Córdoba. Departmento de Microbiologia)
Barreto, Lina (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Yenush, Lynne (Instituto de Biologia Molecular y Celular de Plantas (València, Espanya))
Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Ramos, José (Universidad de Córdoba. Departmento de Microbiologia)
Kschischo, Maik (University of Applied Sciences. Department of Mathematics and Technology (Koblenz, Alemanya))

Data: 2012
Resum: The intrinsic ability of cells to adapt to a wide range of environmental conditions is a fundamental process required for survival. Potassium is the most abundant cation in living cells and is required for essential cellular processes, including the regulation of cell volume, pH and protein synthesis. Yeast cells can grow from low micromolar to molar potassium concentrations and utilize sophisticated control mechanisms to keep the internal potassium concentration in a viable range. We developed a mathematical model for Saccharomyces cerevisiae to explore the complex interplay between biophysical forces and molecular regulation facilitating potassium homeostasis. By using a novel inference method (“the reverse tracking algorithm”) we predicted and then verified experimentally that the main regulators under conditions of potassium starvation are proton fluxes responding to changes of potassium concentrations. In contrast to the prevailing view, we show that regulation of the main potassium transport systems (Trk1,2 and Nha1) in the plasma membrane is not sufficient to achieve homeostasis.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; publishedVersion
Matèria: Potassium ; Protons ; Bicarbonates ; Homeostasis ; Cell membranes ; Starvation ; Homeostatic mechanisms ; Membrane potential
Publicat a: PLOS Computational Biology, Vol. 8, Issue 6 (June 2012) , p. e1002548, ISSN 1553-734X

DOI: 10.1371/journal.pcbi.1002548


11 p, 609.4 KB

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