Per citar aquest document: http://ddd.uab.cat/record/112720
Differential interactions of virulent and non-virulent H. parasuis strains with naïve or swine influenza virus pre-infected dendritic cells
Mussá, Tufária Nazimo Ibrahimo (Fundació Centre de Recerca en Sanitat Animal)
Rodríguez Cariño, Carolina (Universidad Central de Venezuela. Facultad de Ciencias Veterinarias)
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Facultat de Biociències)
Baratelli, Massimiliano (Fundació Centre de Recerca en Sanitat Animal)
Costa Hurtado, Mar (Fundació Centre de Recerca en Sanitat Animal)
Fraile Sauce, Lorenzo José (Universitat de Lleida)
Domínguez Juncal, Javier (Instituto Nacional de Investigaciones Agrarias (Espanya))
Aragón Fernández, Virginia (Fundació Centre de Recerca en Sanitat Animal)
Montoya González, Maria (Institut de Recerca i Tecnologia Agroalimentàries)

Data: 2012
Resum: Pigs possess a microbiota in the upper respiratory tract that includes Haemophilus parasuis. Pigs are also considered the reservoir of influenza viruses and infection with this virus commonly results in increased impact of bacterial infections, including those by H. parasuis. However, the mechanisms involved in host innate responses towards H. parasuis and their implications in a co-infection with influenza virus are unknown. Therefore, the ability of a non-virulent H. parasuis serovar 3 (SW114) and a virulent serovar 5 (Nagasaki) strains to interact with porcine bone marrow dendritic cells (poBMDC) and their modulation in a co-infection with swine influenza virus (SwIV) H3N2 was examined. At 1 hour post infection (hpi), SW114 interaction with poBMDC was higher than that of Nagasaki, while at 8 hpi both strains showed similar levels of interaction. The co-infection with H3N2 SwIV and either SW114 or Nagasaki induced higher levels of IL-1β, TNF-α, IL-6, IL-12 and IL-10 compared to mock or H3N2 SwIV infection alone. Moreover, IL-12 and IFN-α secretion differentially increased in cells co-infected with H3N2 SwIV and Nagasaki. These results pave the way for understanding the differences in the interaction of non-virulent and virulent strains of H. parasuis with the swine immune system and their modulation in a viral co-infection.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Document: article ; publishedVersion
Publicat a: Veterinary research, Vol. 43, N. 80 (November 2012) , p. 1-13, ISSN 1297-9716

DOI: 10.1186/1297-9716-43-80


14 p, 3.9 MB

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