Per citar aquest document: http://ddd.uab.cat/record/113276
Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates
Gimeno Terradellas, Mariona (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Martín i Castillo, Margarita (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)

Data: 2011
Resum: The present study examined the immunological response of antigen presenting cells (APC) to genotype-I isolates of porcine reproductive and respiratory syndrome virus (PRRSV) infection by analysing the cytokine profile induced and evaluating the changes taking place upon infection on immunologically relevant cell markers (MHCI, MHCII, CD80/86, CD14, CD16, CD163, CD172a, SWC9). Several types of APC were infected with 39 PRRSV isolates. The results show that different isolates were able to induce different patterns of IL-10 and TNF-α. The four possible phenotypes based on the ability to induce IL-10 and/or TNF-α were observed, although different cell types seemed to have different capabilities. In addition, isolates inducing different cytokine-release profiles on APC could induce different expression of cell markers.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Document: article ; publishedVersion
Publicat a: Veterinary research, Vol. 42, Núm. 9 (January 2011) , p. 1-10, ISSN 1297-9716

DOI: 10.1186/1297-9716-42-9


10 p, 1.3 MB

El registre apareix a les col·leccions:
Articles > Articles publicats

 Registre creat el 2013-11-12, darrera modificació el 2016-09-30



   Favorit i Compartir