Per citar aquest document: http://ddd.uab.cat/record/113379
Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population
Balcells Ortega, Ingrid (Universitat Autònoma de Barcelona. Departament de Genètica Animal)
Castelló, Anna (Universitat Autònoma de Barcelona. Departament de Genètica Animal)
Mercadé Carceller, Anna (Universitat Autònoma de Barcelona. Servei Veterinari de Genètica Molecular)
Noguera, José L. (Institut de Recerca i Tecnologia Agroalimentàries)
Fernández-Rodríguez, Amanda (Instituto Nacional de Investigaciones Agrarias (Espanya))
Sánchez Bonastre, Armando (Universitat Autònoma de Barcelona. Departament de Genètica Animal)
Tomás Sangenís, Anna (FISIB. Program Infection and Immunity (Bunyola, Espanya))

Data: 2011
Resum: Background: Reproductive traits, such as prolificacy, are of great interest to the pig industry. Better understanding of their genetic architecture should help to increase the efficiency of pig productivity through the implementation of marker assisted selection (MAS) programmes. Results: The Mucin 4 (MUC4) gene has been evaluated as a candidate gene for a prolificacy QTL described in an Iberian × Meishan (Ib × Me) F2 intercross. For association analyses, two previously described SNPs (DQ124298:g. 243A>G and DQ124298:g. 344A>G) were genotyped in 347 pigs from the Ib × Me population. QTL for the number of piglets born alive (NBA) and for the total number of piglets born (TNB) were confirmed on SSC13 at positions 44 cM and 51 cM, respectively. The MUC4 gene was successfully located within the confidence intervals of both QTL. Only DQ124298:g. 344A>G MUC4 polymorphism was significantly associated with both NBA and TNB (P-value < 0. 05) with favourable effects coming from the Meishan origin. MUC4 expression level was determined in F2 sows displaying extreme phenotypes for the number of embryos (NE) at 30-32 days of gestation. Differences in the uterine expression of MUC4 were found between high (NE ≥ 13) and low (NE ≤ 11) prolificacy sows. Overall, MUC4 expression in high prolificacy sows was almost two-fold increased compared with low prolificacy sows. Conclusions: Our data suggest that MUC4 could play an important role in the establishment of an optimal uterine environment that would increase embryonic survival during pig gestation.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; publishedVersion
Publicat a: BMC Genetics, Vol. 12, N. 93 (October 2011) , p. 1-6, ISSN 1471-2156

DOI: 10.1186/1471-2156-12-93


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