Per citar aquest document: http://ddd.uab.cat/record/113398
Relationship between intima-media thickness of the common carotid artery and arterial stiffness in subjects with and without type 2 diabetes : A case-series report
Gómez Marcos, Manuel Ángel (Centro de salud La Alamedilla (Salamanca, Castella i Lleó))
Recio Rodríguez, Jose I. (Centro de salud La Alamedilla (Salamanca, Castella i Lleó))
Patino Alonso, María Carmen (Universidad de Salamanca. Departamento de Estadística)
Agudo Conde, Cristina (Centro de salud La Alamedilla (Salamanca, Castella i Lleó))
Gómez Sánchez, Leticia (Centro de salud La Alamedilla (Salamanca, Castella i Lleó))
Rodríguez Sánchez, Emiliano (Centro de salud La Alamedilla (Salamanca, Castella i Lleó))
Martín Cantera, Carlos (Universitat Autónoma de Barcelona. Departament de Medicina)
García Ortiz, Luís (Centro de salud La Alamedilla (Salamanca, Castella i Lleó))

Data: 2011
Resum: Background: We examined the relationship between the intima-media thickness of the common carotid artery (CCA-IMT) and arterial stiffness, assessed by pulse wave velocity (PWV), the ambulatory arterial stiffness index (AASI) and the augmentation index (AIx) in subjects with and without type 2 diabetes. Methods: A case-series study was made in 366 patients (105 diabetics and 261-non-diabetics). Ambulatory blood pressure monitoring was performed on a day of standard activity with the SpaceLabs 90207 system. AASI was calculated as "1-slope" from the within-person regression of diastolic-on-systolic ambulatory blood pressure readings. PWV and AIx were measured with the SphygmoCor system, and a Sonosite Micromax ultrasound unit was used for automatic measurements of CCA-IMT. Results: PWV, AASI and CCA-IMT were found to be greater in diabetic patients, while no differences in AIx were observed between the two groups. CCA-IMT was independently correlated to the three measures of arterial stiffness in both groups. We found an increase in CCA-IMT of 0. 40, 0. 24 and 0. 36 mm in diabetics, and of 0. 48, 0. 17 and 0. 55 mm in non-diabetics for each unit increase in AASI, AIx and PWV. The variability of CCA-IMT was explained mainly by AASI, AIx and gender in diabetic patients, and by age, gender, AASI and PWV in non-diabetic patients. Conclusions: CCA-IMT showed a positive correlation to PWV, AASI and AIx in subjects with and without type 2 diabetes. However, when adjusting for age, gender and heart rate, the association to PWV was lost in diabetic patients, in the same way as the association to Alx in non-diabetic patients. The present study demonstrates that the three measures taken to assess arterial stiffness in clinical practice are not interchangeable, nor do they behave equally in all subjects.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; publishedVersion
Publicat a: Cardiovascular diabetology, Vol. 10, N. 3 (January 2011) , p. 3-3, ISSN 1475-2840

DOI: 10.1186/1475-2840-10-3


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