Per citar aquest document: http://ddd.uab.cat/record/113554
Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma
Lavarino, Cinzia (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Cheung, Nai-Kong V. (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica))
García, Idoia (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Domènech Gómez, Gemma (Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva)
Torres, Carmen de (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Alaminos, Miguel (Universidad de Granada. Departamento de Histología)
Ríos Guillermo, José (Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva)
Gerald, William L. (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica))
Kushner, Brian (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica))
LaQuaglia, Mike (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica))
Mora, Jaume (Hospital Sant Joan de Déu (Barcelona, Catalunya))

Data: 2009
Resum: Background: Neuroblastoma (NB) tumours have the highest incidence of spontaneous remission, especially among the stage 4s NB subgroup affecting infants. Clinical distinction of stage 4s from lethal stage 4 can be difficult, but critical for therapeutic decisions. The aim of this study was to investigate chromosomal alterations and differential gene expression amongst infant disseminated NB subgroups. Methods: Thirty-five NB tumours from patients diagnosed at < 18 months (25 stage 4 and 10 stage 4s), were evaluated by allelic and gene expression analyses. Results: All stage 4s patients underwent spontaneous remission, only 48% stage 4 patients survived despite combined modality therapy. Stage 4 tumours were 90% near-diploid/tetraploid, 44% MYCN amplified, 77% had 1p LOH (50% 1p36), 23% 11q and/or 14q LOH (27%) and 47% had 17q gain. Stage 4s were 90% near-triploid, none MYCN amplified and LOH was restricted to 11q. Initial comparison analyses between stage 4s and 4 < 12 months tumours revealed distinct gene expression profiles. A significant portion of genes mapped to chromosome 1 (P < 0. 0001), 90% with higher expression in stage 4s, and chromosome 11 (P = 0. 0054), 91% with higher expression in stage 4. Less definite expression profiles were observed between stage 4s and 4 < 18m, yet, association with chromosomes 1 (P < 0. 0001) and 11 (P = 0. 005) was maintained. Distinct gene expression profiles but no significant association with specific chromosomal region localization was observed between stage 4s and stage 4 < 18 months without MYCN amplification. Conclusion: Specific chromosomal aberrations are associated with distinct gene expression profiles which characterize spontaneously regressing or aggressive infant NB, providing the biological basis for the distinct clinical behaviour.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Publicat a: BMC Cancer, Vol. 9, N. 44 (February 2009) , p. 1-11, ISSN 1471-2407

DOI: 10.1186/1471-2407-9-44


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