Pruritus is a common feature in sheep infected with the BSE agent
Konold, Timm (Veterinary Laboratories Agency Weybridge (Addlestone, Regne Unit))
Bone, Gemma (Veterinary Laboratories Agency Weybridge (Addlestone, Regne Unit))
Vidal Díez, Alberto (Veterinary Laboratories Agency Weybridge (Addlestone, Regne Unit))
Tortosa Méndez, Raül (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Davis, Andrew (University of Queensland. School of Veterinary Science (Brisbane, Austràlia))
Dexter, Glenda (Veterinary Laboratories Agency Weybridge (Addlestone, Regne Unit))
Hill, Peter (ADAS Drayton (Stratford upon Avon, Regne Unit))
Jeffrey, Martin (Pentlands Science Park. Veterinary Laboratories Agency Lasswade (Penicuik, Regne Unit))
Simmons, Marion M. (Veterinary Laboratories Agency Weybridge (Addlestone, Regne Unit))
Chaplin, Melanie J. (Veterinary Laboratories Agency Weybridge (Addlestone, Regne Unit))
Bellworthy, Susan J. (Veterinary Laboratories Agency Weybridge (Addlestone, Regne Unit))
Berthelin-Baker, Christine (All Animals Neurology & Neurosurgery (Atlanta, Estats Units d'Amèrica))

Date:	2008
Abstract:	Background: The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine spongiform encephalopathy (BSE), has been attributed to prion protein genotype, strain, breed, clinical duration, dose, route and type of inoculum and the age at infection. The study aimed to describe the clinical signs in sheep infected with the BSE agent throughout its clinical course to determine whether the clinical signs were as variable as described for classical scrapie in sheep. The clinical signs were compared to BSE-negative sheep to assess if disease-specific clinical markers exist. Results: Forty-seven (34%) of 139 sheep, which comprised 123 challenged sheep and 16 undosed controls, were positive for BSE. Affected sheep belonged to five different breeds and three different genotypes (ARQ/ARQ, VRQ/VRQ and AHQ/AHQ). None of the controls or BSE exposed sheep with ARR alleles were positive. Pruritus was present in 41 (87%) BSE positive sheep; the remaining six were judged to be pre-clinically infected. Testing of the response to scratching along the dorsum of a sheep proved to be a good indicator of clinical disease with a test sensitivity of 85% and specificity of 98% and usually coincided with weight loss. Clinical signs that were displayed significantly earlier in BSE positive cases compared to negative cases were behavioural changes, pruritic behaviour, a positive scratch test, alopecia, skin lesions, teeth grinding, tremor, ataxia, loss of weight and loss of body condition. The frequency and severity of each specific clinical sign usually increased with the progression of disease over a period of 16-20 weeks. Conclusion: Our results suggest that BSE in sheep presents with relatively uniform clinical signs, with pruritus of increased severity and abnormalities in behaviour or movement as the disease progressed. Based on the studied sheep, these clinical features appear to be independent of breed, affected genotype, dose, route of inoculation and whether BSE was passed into sheep from cattle or from other sheep, suggesting that the clinical phenotype of BSE is influenced by the TSE strain more than by other factors. The clinical phenotype of BSE in the genotypes and breed studied was indistinguishable from that described for classical scrapie cases.
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	BMC veterinary research, Vol. 4, Núm. 16 (April 2008) , p. 1-15, ISSN 1746-6148

DOI: 10.1186/1746-6148-4-16
PMID: 18445253

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