Home > Articles > Published articles > Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering |
Date: | 2010 |
Abstract: | Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silvercolloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. |
Rights: | Tots els drets reservats. |
Language: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Subject: | DNA ; Silver ; Colloidal systems ; Raman spectra ; Surface enhanced ; Raman scattering ; Metal surfaces ; Elasticity ; Metal optics ; Scattering measurements |
Published in: | Applied physics letters, Vol. 96, Issue 21 (May 2010) , p. 213701/1-213701/3, ISSN 1077-3118 |
4 p, 341.8 KB |