Nondestructive thickness measurement of biological layers at the nanoscale by simultaneous topography and capacitance imaging
Casuso, Ignacio (Universitat de Barcelona. Departament d'Electrònica)
Fumagalli, Laura (Universitat de Barcelona. Departament d'Electrònica)
Gomila, Gabriel (Universitat de Barcelona. Departament d'Electrònica)
Padrós, Esteve (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
American Physical Society

Fecha:	2007
Resumen:	Nanoscale capacitance images of purple membrane layers are obtained simultaneously to topography in a nondestructive manner by operating alternating current sensing atomic force microscopy in jumping mode. Capacitance images show excellent agreement with theoretical modeling and prove to be a noninvasive method for measuring the thickness of purple membrane layers beyond the single monolayer limit with nanoscale lateral spatial resolution. With the ability of spatially resolving the capacitance while preserving the sample from damaging, this technique can be applied for nanoscale thickness measurement of other biological layers and soft materials in general.
Derechos:	Tots els drets reservats.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Capacitance ; Electric measurements ; Bioelectrochemistry ; Topography ; Gold ; Atomic force microscopy ; Monolayers ; Alternating current power transmission ; Nanomaterials ; Spatial resolution
Publicado en:	Applied physics letters, Vol. 91, Issue 6 (August 2007) , p. 063111/1-063111/3, ISSN 1077-3118

DOI: 10.1063/1.2767979

4 p, 494.5 KB

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