Effects of voluntary physical exercise, citicoline, and combined treatment on object recognition memory, neurogenesis and neuroprotection after traumatic brain injury in rats
Jacotte Simancas, Alejandra (Universitat Autònoma de Barcelona. Institut de Neurociències)
Costa Miserachs, David (Universitat Autònoma de Barcelona. Institut de Neurociències)
Coll-Andreu, Margalida (Coll Andreu) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Torras Garcia, Meritxell (Universitat Autònoma de Barcelona. Institut de Neurociències)
Borlongan, César V. (University of South Florida. Center of Excellence for Aging and Brain Repair)
Portell Cortés, Isabel (Universitat Autònoma de Barcelona. Institut de Neurociències)

Fecha:	2015
Resumen:	The biochemical and cellular events that lead to secondary neural damage after traumatic brain injury (TBI) contribute to long-term disabilities, including memory deficits. There is a need to search for single and/or combined treatments aimed at reducing these TBI-related dysfunctions. The effects of citicoline and of voluntary physical exercise in a running wheel (3 weeks), alone or in combination, on TBI-related short-term (3 h) and long-term (24 h) object recognition memory (ORM) deficits, and on neurogenesis and neuroprotection were examined using a rodent model of TBI(controlled cortical impact injury). Citicoline improved memory deficits at the two times tested, while physical exercise only in the long-term test. Physical exercise had a clear neuroprotective effect as indicated by reduced interhemispheric differences in hippocampal formation and lateral ventricle volumes and in density of mature neurons in the hilus of the dentate gyrus and the perirhinal cortex. Physical exercise also increased cell proliferation and neurogenesis in the granular cell layer of the dentate gyrus. Some degree of neuroprotection of citicoline was suggested by reduced interhemispheric differences in the volume of the hippocampal formation. Contrary to what was expected, the effects of citicoline and physical exercise did not sum up. Furthermore, a negative interference between both treatments was found in several behavioral and histological variables. The promising profiles of both treatments as therapeutic tools in TBI when applied singly, underscore the need to carry out further works looking for other combined treatment regimens that increase the benefit of each treatment alone.
Nota:	Final publication is available from Mary Ann Liebert, Inc., publishers. http://dx.doi.org/10.1089/neu.2014.3502
Derechos:	Tots els drets reservats.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió acceptada per publicar
Materia:	Traumatic brain injury ; Voluntary physical exercise ; Citicoline ; Object recognition memory ; Neurogenesis and Neuroprotection
Publicado en:	Journal of neurotrauma, Vol. 32, Num. 10 (2015) , p. 739-751, ISSN 0897-7151

DOI: 10.1089/neu.2014.3502

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Neurociències (INc)
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