Per citar aquest document: http://ddd.uab.cat/record/132803
Integrating mechanical and biological control of cell proliferation through bioinspired multi-effector materials
Seras Franzoso, Joaquin (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Tatkiewicz, Witold (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina)
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Garcia Fruitós, Elena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Ratera Bastardas, Imma (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina)
Veciana i Miró, Jaume (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina)
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Data: 2015
Resum: In nature, cells respond to complex mechanical and biological stimuli whose understanding is required for tissue construction in regenerative medicine. However, the full replication of such bimodal effector networks is far to be reached. Engineering substrate roughness and architecture allows regulating cell adhesion, positioning, proliferation, differentiation and survival, and the external supply of soluble protein factors (mainly growth factors and hormones) has been long applied to promote growth and differentiation. Further, bioinspired scaffolds are progressively engineered as reservoirs for the in situ sustained release of soluble protein factors from functional topographies. We review here how research progresses toward the design of integrative, holistic scaffold platforms based on the exploration of individual mechanical and biological effectors and their further combination.
Nota: Número d'acord de subvenció ISCIII/FIS/PI12/00327
Nota: Número d'acord de subvenció MINECO/BIO2013-41019P
Drets: Tots els drets reservats.
Llengua: Anglès.
Document: article ; recerca ; acceptedVersion
Matèria: Topography ; Regenerative medicine ; Adhesion proteins ; Hydrogels ; Growth factor release ; Bioscaffolds
Publicat a: Nanomedicine (Lond), Vol. 10 issue 5 (2015) , p. 873-891, ISSN 1743-5889

DOI: 10.2217/nnm.15.5


Post-print
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