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Towards Protein-Based Viral Mimetics for Cancer Therapies
Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Céspedes, María Virtudes (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina)
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Ferrer Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Mangues, Ramón (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina)
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Data: 2015
Resum: High resistance and recurrence rates, together with elevated drug clearance, compel the use of maximum-tolerated drug doses in cancer therapy, resulting in high-grade toxicities and limited clinical applicability. Promoting active drug accumulation in tumor tissues would minimize such issues and improve therapeutic outcomes. A new class of therapeutic drugs suitable for the task has emerged based on the concept of virus-mimetic nanocarriers, or 'artificial viruses'. Among the spectrum of materials under exploration in nanocarrier research, proteins offer unparalleled structural and functional versatility for designing virus-like molecular vehicles. By exhibiting 'smart' functions and biomimetic traits, protein-based nanocarriers will be a step ahead of the conventional drug-protein conjugates already in the clinic in ensuring efficient delivery of passenger antitumor drugs.
Nota: The authors acknowledge the financial support on the development of nano-therapeutics in cancer granted to E.V. (PI12/00327) and R.M. (PI12/01861) from the Fund for Health of Spain (FIS) to E.V. (TV32013-133930), and to R.M. and A.V. (TV32013-132031) from La Marató de TV3 (416/C/2013), to A.V. from MINECO (BIO2013-41019-P), and from the Centro de Investigación Biomédica en Red (CIBER) de Bioingeniería, Biomateriales y Nanomedicina (NANOPROTHER and NANOCOMETS projects), financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. U.U. received a fellowship grant from Instituto de Salud Carlos III (ISCIII). A.V. has been distinguished with an ICREA ACADEMIA Award.
Nota: Número d'acord de subvenció MINECO/BIO2013-41019P
Nota: Número d'acord de subvenció ISCIII/FIS/PI12/00327
Nota: Número d'acord de subvenció ISCIII/FIS/PI12/01861
Drets: Tots els drets reservats.
Llengua: Anglès
Document: article ; recerca ; acceptedVersion
Matèria: Protein nanoparticles ; Nanoparticles de proteïnes ; Drug delivery ; Administració de medicaments ; Biomaterials ; Biomimetics ; Biomimètica ; Protein engineering ; Enginyeria de proteïnes ; Targeted therapy
Publicat a: Trends in biotechnology, Vol. 33, Issue 5 (May 2015) , p. 253-258, ISSN 0167-7799

DOI: 10.1016/j.tibtech.2015.02.007


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