Per citar aquest document: http://ddd.uab.cat/record/142738
Colour of sputum is a marker for bacterial colonisation in chronic obstructive pulmonary disease
Miravitlles, Marc (Fundació Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Marín, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Monsó Molas, Eduard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Vilà, Sara (Fundació Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
de la Roza, Cristian (Bayer Schering Pharma)
Hervás, Ramona (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Esquinas, Cristina (Fundació Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
García Núñez, Marian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Morera Prat, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Torres Martí, Antoni (Hospital Clínic de Barcelona. Institut Clínic del Tòrax)

Data: 2010
Resum: Background: Bacterial colonisation in chronic obstructive pulmonary disease (COPD) contributes to airway inflammation and modulates exacerbations. We assessed risk factors for bacterial colonisation in COPD. Methods: Patients with stable COPD consecutively recruited over 1 year gave consent to provide a sputum sample for microbiologic analysis. Bronchial colonisation by potentially pathogenic microorganisms (PPMs) was defined as the isolation of PPMs at concentrations of ≥102 colony-forming units (CFU)/mL on quantitative bacterial culture. Colonised patients were divided into high (>105 CFU/mL) or low (<105 CFU/mL) bacterial load. Results: A total of 119 patients (92. 5% men, mean age 68 years, mean forced expiratory volume in one second [FEV1] [% predicted] 46. 4%) were evaluated. Bacterial colonisation was demonstrated in 58 (48. 7%) patients. Patients with and without bacterial colonisation showed significant differences in smoking history, cough, dyspnoea, COPD exacerbations and hospitalisations in the previous year, and sputum colour. Thirty-six patients (62% of those colonised) had a high bacterial load. More than 80% of the sputum samples with a dark yellow or greenish colour yielded PPMs in culture. In contrast, only 5. 9% of white and 44. 7% of light yellow sputum samples were positive (P < 0. 001). Multivariate analysis showed an increased degree of dyspnoea (odds ratio [OR] = 2. 63, 95% confidence interval [CI] 1. 53-5. 09, P = 0. 004) and a darker sputum colour (OR = 4. 11, 95% CI 2. 30-7. 29, P < 0. 001) as factors associated with the presence of PPMs in sputum. Conclusions: Almost half of our population of ambulatory moderate to very severe COPD patients were colonised with PPMs. Patients colonised present more severe dyspnoea, and a darker colour of sputum allows identification of individuals more likely to be colonised.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Publicat a: Respiratory research, Vol. 11, Núm. 58 (2010) , ISSN 1465-9921

DOI: 10.1186/1465-9921-11-58


9 p, 745.1 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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 Registre creat el 2015-11-03, darrera modificació el 2016-09-29



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