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Scopus: 4 cites, Web of Science: 3 cites,
Stress-induced sensitization: the hypothalamic–pituitary–adrenal axis and beyond
Belda Poyato, Francisco Javier (Universitat Autònoma de Barcelona. Institut de Neurociències)
Fuentes García, Silvia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Daviu Abant, Núria (Universitat Autònoma de Barcelona. Institut de Neurociències)
Nadal i Alemany, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències)
Armario García, Antonio (Universitat Autònoma de Barcelona. Institut de Neurociències)

Data: 2015
Resum: Exposure to certain acute and chronic stressors results in an immediate behavioral and physiological response to the situation followed by a period of days when cross-sensitization to further novel stressors is observed. Cross-sensitization affects to different behavioral and physiological systems, more particularly to the hypothalamus-pituitary-adrenal (HPA) axis. It appears that the nature of the initial (triggering) stressor plays a major role, HPA cross-sensitization being more widely observed with systemic or high-intensity emotional stressors. Less important appears to be the nature of the novel (challenging) stressor, although HPA cross-sensitization is better observed with short duration (5–15 min) challenging stressors. In some studies with acute immune stressors, HPA sensitization appears to develop over time (incubation), but most results indicate a strong initial sensitization that progressively declines over the days. Sensitization can affect other physiological system (i. e. plasma catecholamines, brain monoamines), but it is not a general phenomenon. When studied concurrently, behavioral sensitization appears to persist longer than that of the HPA axis, a finding of interest regarding long-term consequences of traumatic stress. In many cases, behavioral and physiological consequences of prior stress can only be observed following imposition of a new stressor, suggesting long-term latent effects of the initial exposure.
Drets: Tots els drets reservats
Llengua: Anglès
Document: article ; recerca ; acceptedVersion
Matèria: ACTH ; Catecholamines ; Corticosterone ; Electric shock ; Immobilization ; Immune stressors ; Prolactin ; PTSD
Publicat a: Stress, Vol. 18 Núm. 3 (2015) , p. 269-279, ISSN 1025-3890

DOI: 10.3109/10253890.2015.1067678

35 p, 397.0 KB

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 Registre creat el 2015-11-06, darrera modificació el 2016-09-02

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