Per citar aquest document: http://ddd.uab.cat/record/154478
Comprehensive description of clinical characteristics of a large systemic Lupus Erythematosus Cohort from the Spanish Rheumatology Society Lupus Registry (RELESSER) with emphasis on complete versus incomplete lupus differences
Rúa-Figueroa, Íñigo (Hospital Universitario de Gran Canaria Dr. Negrín)
Richi, Patricia (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes, Madrid))
López-Longo, Francisco Javier (Hospital Gregorio Marañón (Madrid))
Galindo, María (Hospital Universitario 12 de Octubre (Madrid))
Calvo Alén, Jaime (Hospital Sierrallana (Torrelavega, Cantabria))
Olivé Marqués, Alejandro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Loza-Santamaría, Estíbaliz (Sociedad Española de Reumatología)
Pérez Vicente, Sabina (Sociedad Española de Reumatología)
Erausquin, Celia (Hospital Universitario de Gran Canaria Dr. Negrín)
Tomero, Eva (Hospital Universitario de la Princesa (Madrid))
Horcada, Loreto (Hospital de Navarra)
Uriarte, Esther (Hospital Donostia (San Sebastián))
Sánchez-Atrio, Ana (Hospital Universitario Príncipe de Asturias (Alcalá de Henares, Madrid))
Rosas, José (Hospital Marina Baixa (La Vila Joiosa, Alacant))
Montilla, Carlos (Hospital Universitario de Salamanca)
Fernández Nebro, Antonio (Hospital Regional Universitario de Málaga)
Rodríguez-Gómez, Manuel (Complexo Hospitalario Universitario de Ourense)
Vela, Paloma (Hospital General Universitario de Alicante)
Blanco, Ricardo (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Freire, Mercedes (Complejo Hospitalario Universitario Juan Canalejo (La Corunya, Galícia))
Silva, Lucía (Hospital Universitario de Guadalajara)
Díez-Álvarez, Elvira (Hospital de León)
Ibáñez-Barceló, Mónica (Hospital Son Llàtzer (Palma de Mallorca, Balears))
Zea, Antonio (Hospital Ramón y Cajal (Madrid))
Narváez García, Francisco Javier (Hospital de Bellvitge)
Martínez-Taboada, Víctor (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Marenco, José Luis (Hospital de Valme (Sevilla))
Fernández de Castro, Mónica (Hospital Universitario Puerta de Hierro Majadahonda)
Fernández-Berrizbeitia, Olaia (Hospital de Basurto (Bilbao, Biscaia))
Hernández-Beriain, José Ángel (Complejo Hospitalario Universitario Insular Materno Infantil (Las Palmas de Gran Canaria))
Gantes, Marian (Hospital Universitario de Canarias (Santa Cruz de Tenerife))
Hernández-Cruz, Blanca (Hospital Virgen de la Macarena (Sevilla))
Pérez-Venegas, José J. (Hospital Jerez de la Frontera)
Pecondón, Ángela (Hospital Universitario Miguel Servet (Saragossa, Aragó))
Marras, Carlos (Hospital Universitario Virgen de la Arrixaca (Múrcia))
Carreira, Patricia (Hospital Universitario 12 de Octubre (Madrid))
Bonilla, Gema (Hospital Universitario La Paz (Madrid))
Torrente, Vicente (Hospital General de l'Hospitalet (L'Hospitalet De Llobregat, Barcelona))
Castellví, Iván (Hospital Comarcal de l'Alt Penedès (Vilafranca del Penedès, Barcelona))
Alegre, Juan (Hospital Universitario Dr. Peset (València))
Moreno, Mireia (Corporació Sanitària Parc Taulí)
Raya, Enrique (Hospital Universitario San Cecilio (Granada))
García de la Peña, Paloma (Hospital de Madrid Norte-Sanchinarro)
Vázquez, Tomás (Hospital Universitario Lucus Augusti (Lugo))
Aguirre, Ángeles (Hospital Universitario Reina Sofía (Còrdova))
Quevedo, Víctor (Hospital Comarcal de Monforte de Lemos (Lugo))
Pego-Reigosa, José M. (Instituto de Investigación Biomédica de Vigo)

Data: 2015
Resum: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ involvement and pronounced racial and ethnic heterogeneity. The aims of the present work were (1) to describe the cumulative clinical characteristics of those patients included in the Spanish Rheumatology Society SLE Registry (RELESSER), focusing on the differences between patients who fulfilled the 1997 ACR-SLE criteria versus those with less than 4 criteria (hereafter designated as incomplete SLE (iSLE)) and (2) to compare SLE patient characteristics with those documented in other multicentric SLE registries. RELESSER is a multicenter hospital-based registry, with a collection of data from a large, representative sample of adult patients with SLE (1997 ACR criteria) seen at Spanish rheumatology departments. The registry includes demographic data, comprehensive descriptions of clinical manifestations, as well as information about disease activity and severity, cumulative damage, comorbidities, treatments and mortality, using variables with highly standardized definitions. A total of 4. 024 SLE patients (91% with ≥4 ACR criteria) were included. Ninety percent were women with a mean age at diagnosis of 35. 4 years and a median duration of disease of 11. 0 years. As expected, most SLE manifestations were more frequent in SLE patients than in iSLE ones and every one of the ACR criteria was also associated with SLE condition; this was particularly true of malar rash, oral ulcers and renal disorder. The analysis—adjusted by gender, age at diagnosis, and disease duration—revealed that higher disease activity, damage and SLE severity index are associated with SLE [OR: 1. 14; 95% CI: 1. 08–1. 20 (P < 0. 001); 1. 29; 95% CI: 1. 15–1. 44 (P < 0. 001); and 2. 10; 95% CI: 1. 83–2. 42 (P < 0. 001), respectively]. These results support the hypothesis that iSLE behaves as a relative stable and mild disease. SLE patients from the RELESSER register do not appear to differ substantially from other Caucasian populations and although activity [median SELENA-SLEDA: 2 (IQ: 0–4)], damage [median SLICC/ACR/DI: 1 (IQ: 0–2)], and severity [median KATZ index: 2 (IQ: 1–3)] scores were low, 1 of every 4 deaths was due to SLE activity. RELESSER represents the largest European SLE registry established to date, providing comprehensive, reliable and updated information on SLE in the southern European population.
Nota: Número d'acord de subvenció EC/FP7/316265
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Publicat a: Medicine, Vol. 94, Núm. 1 (January 2015) , p. e267, ISSN 0025-7974

DOI: 10.1097/MD.0000000000000267


10 p, 193.8 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2016-05-23, darrera modificació el 2016-10-06



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