Per citar aquest document: http://ddd.uab.cat/record/154479
Cardiovascular events in Systemic Lupus Erythematosus: a nationwide study in Spain from the RELESSER Registry
Fernández Nebro, Antonio (Hospital Regional Universitario de Málaga)
Rúa-Figueroa, Íñigo (Hospital Universitario de Gran Canaria Dr. Negrín)
López-Longo, Francisco Javier (Hospital Gregorio Marañón (Madrid))
Galindo-Izquierdo, María (Hospital Universitario 12 de Octubre (Madrid))
Calvo Alén, Jaime (Hospital Sierrallana (Torrelavega, Cantabria))
Olivé Marqués, Alejandro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ordóñez-Cañizares, Carmen (Hospital Regional Universitario de Málaga)
Martín-Martínez, María A. (Sociedad Española de Reumatología)
Blanco, Ricardo (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Melero-González, Rafael (Complexo Hospitalario Universitario de Ourense)
Ibáñez-Rúan, Jesús (Hospital Povisa (Vigo, Pontevedra))
Bernal-Vidal, José Antonio (Hospital General Universitario de Alicante)
Tomero-Muriel, Eva (Hospital Universitario de la Princesa (Madrid))
Uriarte-Isacelaya, Esther (Hospital Donostia (San Sebastián))
Horcada-Rubio, Loreto (Hospital de Navarra)
Freire-González, Mercedes (Complejo Hospitalario Universitario Juan Canalejo (La Corunya, Galícia))
Narváez García, Francisco Javier (Hospital de Bellvitge)
Boteanu, Alina L. (Hospital Ramón y Cajal (Madrid))
Santos-Soler, Gregorio (Hospital Marina Baixa (La Vila Joiosa, Alacant))
Andreu, José L. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Pego-Reigosa, José M. (Instituto de Investigación Biomédica de Vigo)

Data: 2015
Resum: This article estimates the frequency of cardiovascular (CV) events that occurred after diagnosis in a large Spanish cohort of patients with systemic lupus erythematosus (SLE) and investigates the main risk factors for atherosclerosis. RELESSER is a nationwide multicenter, hospital-based registry of SLE patients. This is a cross-sectional study. Demographic and clinical variables, the presence of traditional risk factors, and CV events were collected. A CV event was defined as a myocardial infarction, angina, stroke, and/or peripheral artery disease. Multiple logistic regression analysis was performed to investigate the possible risk factors for atherosclerosis. From 2011 to 2012, 3658 SLE patients were enrolled. Of these, 374 (10. 9%) patients suffered at least a CV event. In 269 (7. 4%) patients, the CV events occurred after SLE diagnosis (86. 2% women, median [interquartile range] age 54. 9 years [43. 2–66. 1], and SLE duration of 212. 0 months [120. 8–289. 0]). Strokes (5. 7%) were the most frequent CV event, followed by ischemic heart disease (3. 8%) and peripheral artery disease (2. 2%). Multivariate analysis identified age (odds ratio [95% confidence interval], 1. 03 [1. 02–1. 04]), hypertension (1. 71 [1. 20–2. 44]), smoking (1. 48 [1. 06–2. 07]), diabetes (2. 2 [1. 32–3. 74]), dyslipidemia (2. 18 [1. 54–3. 09]), neurolupus (2. 42 [1. 56–3. 75]), valvulopathy (2. 44 [1. 34–4. 26]), serositis (1. 54 [1. 09–2. 18]), antiphospholipid antibodies (1. 57 [1. 13–2. 17]), low complement (1. 81 [1. 12–2. 93]), and azathioprine (1. 47 [1. 04–2. 07]) as risk factors for CV events. We have confirmed that SLE patients suffer a high prevalence of premature CV disease. Both traditional and nontraditional risk factors contribute to this higher prevalence. Although it needs to be verified with future studies, our study also shows—for the first time—an association between diabetes and CV events in SLE patients.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Publicat a: Medicine, Vol. 94 Núm. 29 (July 2015) , p. e1183, ISSN 0025-7974

DOI: 10.1097/MD.0000000000001183


9 p, 217.0 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2016-05-23, darrera modificació el 2016-10-06



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