Cardiovascular events in Systemic Lupus Erythematosus: a nationwide study in Spain from the RELESSER Registry
Fernández-Nebro, Antonio (Hospital Regional Universitario de Málaga)
Rua Figueroa, Íñigo (Hospital Universitario de Gran Canaria Dr. Negrín)
López-Longo, Francisco Javier (Hospital General Universitario Gregorio Marañón)
Galindo, María (Hospital Universitario 12 de Octubre (Madrid))
Calvo Alén, Jaime (Hospital Sierrallana (Torrelavega, Cantabria))
Olivé Marqués, Alejandro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ordóñez-Cañizares, Carmen (Hospital Regional Universitario de Málaga)
Martín-Martínez, María A. (Sociedad Española de Reumatología)
Blanco, Ricardo (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Melero-González, Rafael (Complejo Hospitalario Universitario de Ourense)
Ibáñez-Rúan, Jesús (Hospital Povisa (Vigo, Pontevedra))
Bernal-Vidal, José Antonio (Hospital General Universitario de Alicante (Alacant, País Valencià))
Tomero-Muriel, Eva (Hospital Universitario de la Princesa (Madrid))
Uriarte-Isacelaya, Esther (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Horcada-Rubio, Loreto (Complejo Hospitalario de Navarra)
Freire-González, Mercedes (Complejo Hospitalario Universitario Juan Canalejo (La Corunya, Galícia))
Narváez García, Francisco Javier (Hospital Universitari de Bellvitge)
Boteanu, Alina L. (Hospital Universitario Ramón y Cajal (Madrid))
Santos-Soler, Gregorio (Hospital Marina Baixa (La Vila Joiosa, Alacant))
Andréu, José Luis (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Pego-Reigosa, José M. (Instituto de Investigación Biomédica de Vigo)

Date:	2015
Abstract:	This article estimates the frequency of cardiovascular (CV) events that occurred after diagnosis in a large Spanish cohort of patients with systemic lupus erythematosus (SLE) and investigates the main risk factors for atherosclerosis. RELESSER is a nationwide multicenter, hospital-based registry of SLE patients. This is a cross-sectional study. Demographic and clinical variables, the presence of traditional risk factors, and CV events were collected. A CV event was defined as a myocardial infarction, angina, stroke, and/or peripheral artery disease. Multiple logistic regression analysis was performed to investigate the possible risk factors for atherosclerosis. From 2011 to 2012, 3658 SLE patients were enrolled. Of these, 374 (10. 9%) patients suffered at least a CV event. In 269 (7. 4%) patients, the CV events occurred after SLE diagnosis (86. 2% women, median [interquartile range] age 54. 9 years [43. 2-66. 1], and SLE duration of 212. 0 months [120. 8-289. 0]). Strokes (5. 7%) were the most frequent CV event, followed by ischemic heart disease (3. 8%) and peripheral artery disease (2. 2%). Multivariate analysis identified age (odds ratio [95% confidence interval], 1. 03 [1. 02-1. 04]), hypertension (1. 71 [1. 20-2. 44]), smoking (1. 48 [1. 06-2. 07]), diabetes (2. 2 [1. 32-3. 74]), dyslipidemia (2. 18 [1. 54-3. 09]), neurolupus (2. 42 [1. 56-3. 75]), valvulopathy (2. 44 [1. 34-4. 26]), serositis (1. 54 [1. 09-2. 18]), antiphospholipid antibodies (1. 57 [1. 13-2. 17]), low complement (1. 81 [1. 12-2. 93]), and azathioprine (1. 47 [1. 04-2. 07]) as risk factors for CV events. We have confirmed that SLE patients suffer a high prevalence of premature CV disease. Both traditional and nontraditional risk factors contribute to this higher prevalence. Although it needs to be verified with future studies, our study also shows-for the first time-an association between diabetes and CV events in SLE patients.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Medicine, Vol. 94 Núm. 29 (July 2015) , p. e1183, ISSN 1536-5964

DOI: 10.1097/MD.0000000000001183
PMID: 26200625

9 p, 217.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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