Per citar aquest document: http://ddd.uab.cat/record/155715
Relationship of YKL-40 and adiponectin and subclinical atherosclerosis in asymptomatic patients with type 1 diabetes mellitus from a European Mediterranean population
Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Serra Planas, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Granada Ybern, María Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pellitero Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Reverter, Jordi L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mauricio Puente, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona. Departament de Medicina

Data: 2015
Resum: Background: The glycoprotein YKL-40 is a new marker of early inflammation and endothelial dysfunction. Adiponectin is a collagen-like protein with anti-atherogenic and anti-inflammatory effects. Increased concentrations of both markers have been reported in patients with type 1 diabetes (T1D). Aim: To assess the possible role of YKL-40 and adiponectin as a marker of subclinical cardiovascular disease in asymptomatic patients with type 1 diabetes with no history of ischemic or macrovascular heart disease and its relationship with other classic inflammatory biomarkers. Methods: Concentrations of YKL-40, adiponectin, IL-6, IL-1β, TNF- α, hsCRP and homocysteine were determined in 150 T1D patients (58 % men, age: 38. 6 ± 8. 1 years, 20. 4 ± 8. 1 years of evolution, BMI: 25. 1 ± 3. 6 kg/m2; HbA1c 8. 1 ± 2. 3 %, 48 % smokers; 26 % retinopathy, microalbuminuria 9 %) and 50 controls age, sex and smoke condition matched. Subclinical atherosclerosis was assessed by a carotid ultrasonography and a computed tomography for evaluation of calcium artery calcification score (CACS). Results: 82 % of T1D patients and 92 % of controls had a calcium score of 0. T1D patients showed a significantly higher mean common carotid artery intima media thickness (CIMT) compared to controls (0. 55 ± 0. 14 vs 0. 48 ± 0. 14 mm, p = 0. 01). Concentrations of YKL-40 and adiponectin were significantly higher in T1D [42. 6 (10. 4–195. 0) vs ±28. 7 (11. 0–51. 2) ng/ml, p = 0. 001 and 15. 8 ± 9. 1 vs. 12. 4 ± 5. 3 mg/ml, p = 0. 008], with no differences when compared to other inflammatory parameters. In T1D patients no association was found between YKL-40 and adiponectin and screening test for subclinical arterial disease (neither CACS nor CIMT). A positive correlation was found between levels of YKL-40 and age and duration of disease (r = 0. 28, p = 0. 003; r = 0. 35, p = 0. 001). There were no differences in the YKL-40 in relation to the presence or absence of retinopathy or nephropathy. Levels of adiponectin were higher in patients with nephropathy (21. 84 ± 8. 15 vs. 14. 88 ± 8. 27 mg/ml, p = 0. 008). Conclusions: Type 1 diabetes patients from a Mediterranean area with a longer disease evolution, although a lower degree of subclinical disease, showed significatively higher concentrations of YKL-40 and adiponectin compared with the controls. Therefore, we conclude that YKL-40 and adiponectin are early inflammatory markers in diabetic subjects even in the presence of a low atherosclerotic background.
Nota: Número d'acord de subvenció ISCIII/PI12/00183
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Matèria: YKL-40 ; Adiponectin ; Subclinical atherosclerosis ; Type 1 diabetes
Publicat a: Cardiovascular diabetology, Vol. 14, Núm. 121 (September 2015) , ISSN 1475-2840

DOI: 10.1186/s12933-015-0287-z


7 p, 877.3 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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 Registre creat el 2016-06-02, darrera modificació el 2016-10-06



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