Relationship of YKL-40 and adiponectin and subclinical atherosclerosis in asymptomatic patients with type 1 diabetes mellitus from a European Mediterranean population
Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Serra Planas, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Granada, Maria Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pellitero Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Reverter, Jordi L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mauricio Puente, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona.
Departament de Medicina
Data: |
2015 |
Resum: |
Background: The glycoprotein YKL-40 is a new marker of early inflammation and endothelial dysfunction. Adiponectin is a collagen-like protein with anti-atherogenic and anti-inflammatory effects. Increased concentrations of both markers have been reported in patients with type 1 diabetes (T1D). Aim: To assess the possible role of YKL-40 and adiponectin as a marker of subclinical cardiovascular disease in asymptomatic patients with type 1 diabetes with no history of ischemic or macrovascular heart disease and its relationship with other classic inflammatory biomarkers. Methods: Concentrations of YKL-40, adiponectin, IL-6, IL-1β, TNF- α, hsCRP and homocysteine were determined in 150 T1D patients (58 % men, age: 38. 6 ± 8. 1 years, 20. 4 ± 8. 1 years of evolution, BMI: 25. 1 ± 3. 6 kg/m2; HbA1c 8. 1 ± 2. 3 %, 48 % smokers; 26 % retinopathy, microalbuminuria 9 %) and 50 controls age, sex and smoke condition matched. Subclinical atherosclerosis was assessed by a carotid ultrasonography and a computed tomography for evaluation of calcium artery calcification score (CACS). Results: 82 % of T1D patients and 92 % of controls had a calcium score of 0. T1D patients showed a significantly higher mean common carotid artery intima media thickness (CIMT) compared to controls (0. 55 ± 0. 14 vs 0. 48 ± 0. 14 mm, p = 0. 01). Concentrations of YKL-40 and adiponectin were significantly higher in T1D [42. 6 (10. 4-195. 0) vs ±28. 7 (11. 0-51. 2) ng/ml, p = 0. 001 and 15. 8 ± 9. 1 vs. 12. 4 ± 5. 3 mg/ml, p = 0. 008], with no differences when compared to other inflammatory parameters. In T1D patients no association was found between YKL-40 and adiponectin and screening test for subclinical arterial disease (neither CACS nor CIMT). A positive correlation was found between levels of YKL-40 and age and duration of disease (r = 0. 28, p = 0. 003; r = 0. 35, p = 0. 001). There were no differences in the YKL-40 in relation to the presence or absence of retinopathy or nephropathy. Levels of adiponectin were higher in patients with nephropathy (21. 84 ± 8. 15 vs. 14. 88 ± 8. 27 mg/ml, p = 0. 008). Conclusions: Type 1 diabetes patients from a Mediterranean area with a longer disease evolution, although a lower degree of subclinical disease, showed significatively higher concentrations of YKL-40 and adiponectin compared with the controls. Therefore, we conclude that YKL-40 and adiponectin are early inflammatory markers in diabetic subjects even in the presence of a low atherosclerotic background. |
Ajuts: |
Instituto de Salud Carlos III PI12/00183
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Drets: |
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Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
YKL-40 ;
Adiponectin ;
Subclinical atherosclerosis ;
Type 1 diabetes |
Publicat a: |
Cardiovascular diabetology, Vol. 14, Núm. 121 (September 2015) , ISSN 1475-2840 |
DOI: 10.1186/s12933-015-0287-z
PMID: 26382922
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Registre creat el 2016-06-02, darrera modificació el 2023-09-14