Two alternative estimation procedures for the negative binomial cure rate model with a latent activation scheme
Gallardo, Diego (Universidad de Antofagasta (Chile). Departamento de Matemáticas)
Bolfarine, Heleno (Universidade de São Paulo. Departamento de Estatística)

Date:	2016
Abstract:	In this paper two alternative estimation procedures based on the EM algorithm are proposed forthe flexible negative binomial cure rate model with a latent activation scheme. The Weibull modelas well as the log-normal and gamma distributions are also considered for the time-to-event datafor the non-destroyed cells. Simulation studies show the satisfactory performance of the proposedmethodology. The impact of misspecifying the survival function on both components of the model(cured and susceptible) is also evaluated. The use of the new methodology is illustrated with areal data set related to a clinical trial on Phase III cutaneous melanoma patients.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Competing risks ; EM algorithm ; Latent activation scheme
Published in:	SORT : statistics and operations research transactions, Vol. 40 Núm. 1 (January-June 2016) , p. 31-54 (Articles) , ISSN 2013-8830

Adreça alternativa: https://raco.cat/index.php/SORT/article/view/310068

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