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Página principal > Artículos > Artículos publicados > Trisomy 8, a cytogenetic abnormality in Myelodysplastic Syndromes, is constitutional or not? |
Fecha: | 2015 |
Resumen: | Isolated trisomy 8 is not considered presumptive evidence of myelodysplastic syndrome (MDS) in cases without minimal morphological criteria. One reason given is that trisomy 8 (+8) can be found as a constitutional mosaicism (cT8M). We tried to clarify the incidence of cT8M in myeloid neoplasms, specifically in MDS, and the diagnostic value of isolated +8 in MDS. Twenty-two MDS and 10 other myeloid neoplasms carrying +8 were studied. Trisomy 8 was determined in peripheral blood by conventional cytogenetics (CC) and on granulocytes, CD3+ lymphocytes and oral mucosa cells by fluorescence in situ hybridization (FISH). In peripheral blood CC, +8 was seen in 4/32 patients. By FISH, only one patient with chronic myelomonocytic leukemia showed +8 in all cell samples and was interpreted as a cT8M. In our series +8 was acquired in all MDS. Probably, once discarded cT8M by FISH from CD3+ lymphocytes and non-hematological cells, +8 should be considered with enough evidence to MDS. |
Ayudas: | Instituto de Salud Carlos III FI07/00107 Instituto de Salud Carlos III CA08/00141 Instituto de Salud Carlos III PI07/1009 Instituto de Salud Carlos III PI11/02010 Instituto de Salud Carlos III RTICC/RD06/0020/0031 Instituto de Salud Carlos III RTICC/RD07/0020/2004 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-541 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Acute myeloid leukemia ; Lymphocytes ; Cytogenetics ; Fluorescent in situ hybridization ; Granulocytes ; Neoplasms ; Cancer detection and diagnosis ; Leukemias |
Publicado en: | PloS one, Vol. 10, No 6 (June 2015) , p. e0129375, ISSN 1932-6203 |
7 p, 184.9 KB |