EpiFactors : a comprehensive database of human epigenetic factors and complexes
Medvedeva, Yulia A. (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Lennartsson, Andreas (Karolinska Institutet (Estocolm, Suècia))
Ehsani, Rezvan (Norwegian University of Science and Technology (Trondheim, Noruega))
Kulakovskiy, Ivan V. (Vavilov Institute of General Genetics (Moscou, Rússia))
Vorontsov, Ilya E. (Vavilov Institute of General Genetics (Moscou, Rússia))
Panahandeh, Pouda (Norwegian University of Science and Technology (Trondheim, Noruega))
Khimulya, Grigory (Vavilov Institute of General Genetics (Moscou, Rússia))
Kasukawa, Takeya (RIKEN Center for Life Science Technologies (Kobe, Japó))
Drabløs, Finn (Norwegian University of Science and Technology (Trondheim, Noruega))

Data:	2015
Resum:	Abstract: Epigenetics refers to stable and long-term alterations of cellular traits that are not caused by changes in the DNA sequence per se. Rather, covalent modifications of DNA and histones affect gene expression and genome stability via proteins that recognize and act upon such modifications. Many enzymes that catalyse epigenetic modifications or are critical for enzymatic complexes have been discovered, and this is encouraging investigators to study the role of these proteins in diverse normal and pathological processes. Rapidly growing knowledge in the area has resulted in the need for a resource that compiles, organizes and presents curated information to the researchers in an easily accessible and user-friendly form. Here we present EpiFactors, a manually curated database providing information about epigenetic regulators, their complexes, targets and products. EpiFactors contains information on 815 proteins, including 95 histones and protamines. For 789 of these genes, we include expressions values across several samples, in particular a collection of 458 human primary cell samples (for approximately 200 cell types, in many cases from three individual donors), covering most mammalian cell steady states, 255 different cancer cell lines (representing approximately 150 cancer subtypes) and 134 human postmortem tissues. Expression values were obtained by the FANTOM5 consortium using Cap Analysis of Gene Expression technique. EpiFactors also contains information on 69 protein complexes that are involved in epigenetic regulation. The resource is practical for a wide range of users, including biologists, pharmacologists and clinicians.
Ajuts:	Ministerio de Economía y Competitividad FPDI/2013-18088 Ministerio de Economía y Competitividad BFU/2011-30246
Nota:	Altres ajuts: Russian Fund For Basic Research(RFFI)grant 14-04-0018 i grant 15-34-20423, Ake Olsson's foundation, Swedish Cancer foundation, Swedish Childhood cancer foundation, Dynasty Foundation Fellowship, RIKEN Omics Science Center, RIKEN Preventive Medicine and Diagnosis Innovation Program i RIKEN Center for Life Science Technologies.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Epigenètica
Publicat a:	Database, Vol. bav067 (2015) , ISSN 1758-0463

DOI: 10.1093/database/bav067
PMID: 26153137

10 p, 659.4 KB

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