Alcohol Consumption during Pregnancy : Analysis of Two Direct Metabolites of Ethanol in Meconium
Sanvisens, Arantza (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Robert, Neus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Hernández Pérez, José María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Zuluaga Cruz, Andrea Paola (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Coroleu Lletget, Wifredo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Serra Landete, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Tor Aguilera, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Fecha:	2016
Resumen:	Alcohol consumption in young women is a widespread habit that may continue during pregnancy and induce alterations in the fetus. We aimed to characterize prevalence of alcohol consumption in parturient women and to assess fetal ethanol exposure in their newborns by analyzing two direct metabolites of ethanol in meconium. This is a cross-sectional study performed in September 2011 and March 2012 in a series of women admitted to an obstetric unit following childbirth. During admission, socio-demographic and substance use (alcohol, tobacco, cannabis, cocaine, and opiates) during pregnancy were assessed using a structured questionnaire and clinical charts. We also recorded the characteristics of pregnancy, childbirth, and neonates. The meconium analysis was performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) to detect the presence of ethyl glucuronide (EtG) and ethyl sulfate (EtS). Fifty-one parturient and 52 neonates were included and 48 meconium samples were suitable for EtG and EtS detection. The median age of women was 30 years (interquartile range (IQR): 26-34 years); EtG was present in all meconium samples and median concentration of EtG was 67. 9 ng/g (IQR: 36. 0-110. 6 ng/g). With respect to EtS, it was undetectable (<0. 01 ng/g) in the majority of samples (79. 1%). Only three (6%) women reported alcohol consumption during pregnancy in face-to-face interviews. However, prevalence of fetal exposure to alcohol through the detection of EtG and EtS was 4. 2% and 16. 7%, respectively. Prevention of alcohol consumption during pregnancy and the detection of substance use with markers of fetal exposure are essential components of maternal and child health.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Fetal ethanol exposure ; Meconium ; Ethyl glucuronide ; Ethyl sulfate
Publicado en:	International journal of molecular sciences, Vol. 17 Núm. 3 (March 2016) , ISSN 1422-0067

DOI: 10.3390/ijms17030417
PMID: 27011168

12 p, 7.8 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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