Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state
Padilla, Stephanie L. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica))
Qiu, Jian (Oregon Health and Science University (Oregon, Estats Units d'Amèrica))
Soden, Marta E. (University of Washington (Seattle, Estats Units d'Amèrica))
Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències)
Nestor, Casey C. (Oregon Health and Science University (Oregon, Estats Units d'Amèrica))
Barker, Forrest D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica))
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
Zweifel, Larry S. (University of Washington (Seattle, Estats Units d'Amèrica))
Rønnekleiv, Oline K. (Oregon Health and Science University (Oregon, Estats Units d'Amèrica))
Kelly, Martin J. (Oregon Health and Science University (Oregon, Estats Units d'Amèrica))
Palmiter, Richard D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica))

Date:	2016
Abstract:	In the face of starvation, animals will engage in high-risk behaviors that would normally be considered maladaptive. Starving rodents, for example, will forage in areas that are more susceptible to predators and will also modulate aggressive behavior within a territory of limited or depleted nutrients. The neural basis of these adaptive behaviors likely involves circuits that link innate feeding, aggression and fear. Hypothalamic agouti-related peptide (AgRP)-expressing neurons are critically important for driving feeding and project axons to brain regions implicated in aggression and fear. Using circuit-mapping techniques in mice, we define a disynaptic network originating from a subset of AgRP neurons that project to the medial nucleus of the amygdala and then to the principal bed nucleus of the stria terminalis, which suppresses territorial aggression and reduces contextual fear. We propose that AgRP neurons serve as a master switch capable of coordinating behavioral decisions relative to internal state and environmental cues.
Grants:	European Commission 658352 European Commission 638106 Ministerio de Economía y Competitividad SAF2014-57981 Ministerio de Economía y Competitividad RyC-2012-11873
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Hypothalamus ; Sensory processing
Published in:	Nature neuroscience, Vol. 19, Num. 5 (May 2016) , p. 734-741, ISSN 1097-6256

DOI: 10.1038/nn.4274
PMID: 27019015

Post-print 28 p, 14.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles