Per citar aquest document: http://ddd.uab.cat/record/22863
Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species
Costa, Taiana (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Chaves Hernández, Aida Jeannette (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Valle, Rosa (Institut de Recerca i Tecnologia Agroalimentàries)
Darji, Ayub (Institut de Recerca i Tecnologia Agroalimentàries)
van Riel, Debbie (Erasmus Medical Center. Department of Virology)
Kuiken, Thijs (Erasmus Medical Center. Department of Virology)
Majó i Masferrer, Natalia (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Ramis Salva, Antonio José (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)

Data: 2012
Resum: This study assessed the presence of sialic acid α-2,3 and α-2,6 linked glycan receptors in seven avian species. The respiratory and intestinal tracts of the chicken, common quail, red-legged partridge, turkey, golden pheasant, ostrich, and mallard were tested by means of lectin histochemistry, using the lectins Maackia amurensis agglutinin II and Sambucus nigra agglutinin, which show affinity for α-2,3 and α-2,6 receptors, respectively. Additionally, the pattern of virus attachment (PVA) was evaluated with virus histochemistry, using an avian-origin H4N5 virus and a human-origin seasonal H1N1 virus. There was a great variation of receptor distribution among the tissues and avian species studied. Both α-2,3 and α-2,6 receptors were present in the respiratory and intestinal tracts of the chicken, common quail, red-legged partridge, turkey, and golden pheasant. In ostriches, the expression of the receptor was basically restricted to α-2,3 in both the respiratory and intestinal tracts and in mallards the α-2,6 receptors were absent from the intestinal tract. The results obtained with the lectin histochemistry were, in general, in agreement with the PVA. The differential expression and distribution of α-2,3 and α-2,6 receptors among various avian species might reflect a potentially decisive factor in the emergence of new viral strains.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Document: article ; publishedVersion
Matèria: grip aviària ; avian influenza ; respiratory tracts ; intestinal tract
Publicat a: Veterinary research, Vol. 43, (April 2012) , p. 28, ISSN 1297-9716

Adreça alternativa: http://www.veterinaryresearch.org/content/43/1/28
Adreça alternativa: http://www.ncbi.nlm.nih.gov/pubmed/22489675
DOI: 10.1186/1297-9716-43-28


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