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Incorporating patients' characteristics in cost-effectiveness studies with clinical trial data : a flexible Bayesian approach
Vázquez Polo, Francisco José
Negrín Hernández, Miguel Ángel
Universidad de Las Palmas de Gran Canaria

Data: 2004
Resum: Most published research on the comparison between medical treatment options merely compares the results (effectiveness and cost) obtained for each treatment group. The present work proposes the incorporation of other patient characteristics into the analysis. Most of the studies carried out in this context assume normality of both costs and effectiveness. In practice, however, the data are not always distributed according to this assumption. Altervative models have to be developed. In this paper, we present a general model of cost-effectiveness, incorporating both binary effectiveness and skewed cost. In a practical application, we compare two highly active antiretroviral treatments applied to asymptomatic HIV patients. We propose a logit model when the effectiveness is measured depending on whether an initial purpose is achieved. For this model, the measure to compare treatments is the difference in the probability of success. Besides, the cost data usually present a right skewing. We propose the use of the logtransformation to carry out the regression model. The three models are fitted demonstrating the advantages of this modelling. The cost-effectiveness acceptability curve is used as a measure for decision-making.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Matèria: Bayesian analysis ; Cost-effectiveness ; Markov Chain Monte Carlo (MCMC) ; Skewed cost distributions
Publicat a: SORT : statistics and operations research transactions, Vol. 28, Núm. 1 (January-June 2004) , p. 87-108, ISSN 1696-2281

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