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1.
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20 p, 4.3 MB |
Population Disequilibrium as Promoter of Adaptive Explorations in Hepatitis C Virus
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García-Crespo, Carlos (Centro de Biología Molecular Severo Ochoa) ;
Gallego, Isabel (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Soria, María Eugenia (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
de Ávila, Ana Isabel (Centro de Biología Molecular Severo Ochoa) ;
Martínez-González, Brenda (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Vázquez-Sirvent, Lucía (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Lobo-Vega, Rebeca (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Moreno del Olmo, Elena (Centro de Biología Molecular Severo Ochoa) ;
Gómez, Jordi (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Briones Llorente, Carlos (Centro de Astrobiología (Madrid)) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Domingo, Esteban (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Perales Viejo, Celia (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Universitat Autònoma de Barcelona
Replication of RNA viruses is characterized by exploration of sequence space which facilitates their adaptation to changing environments. It is generally accepted that such exploration takes place mainly in response to positive selection, and that further diversification is boosted by modifications of virus population size, particularly bottleneck events. [...]
2021 -  10.3390/v13040616
Viruses, Vol. 13 (april 2021)
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2.
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19 p, 2.2 MB |
Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir
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de Ávila, Ana Isabel (Consejo Superior de Investigaciones Científicas) ;
Gallego, Isabel (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Soria, Maria Eugenia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori i Font, Josep (Roche Diagnostics (Sant Cugat)) ;
Quer, Josep 1963- (Universitat Autònoma de Barcelona) ;
Esteban Mur, Juan Ignacio (Universitat Autònoma de Barcelona) ;
Rice, Charles M. (The Rockefeller University) ;
Domingo, Esteban (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Perales Viejo, Celia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an excess of mutations acquired during replication in the presence of a mutagen. Here we show that favipiravir (T-705) is a potent mutagenic agent for hepatitis C virus (HCV) during its replication in human hepatoma cells. [...]
2016 - 10.1371/journal.pone.0164691
PloS one, Vol. 11 (october 2016)
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3.
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15 p, 3.3 MB |
Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus
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Soria, María Eugenia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Chen, Qian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Cehic, D. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Llorens, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Ávila, Ana Isabel (Centro de Biología Molecular Severo Ochoa) ;
Beach, Nathan M. (Centro de Biología Molecular Severo Ochoa) ;
Domingo, Esteban (Centro de Biología Molecular Severo Ochoa) ;
Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona) ;
Buti, Maria (Universitat Autònoma de Barcelona) ;
Esteban, Rafael (Esteban Mur) (Universitat Autònoma de Barcelona) ;
Esteban Mur, Juan Ignacio (Universitat Autònoma de Barcelona) ;
Quer, Josep 1963- (Universitat Autònoma de Barcelona) ;
Perales Viejo, Celia (Centro de Biología Molecular Severo Ochoa)
Despite the high sustained virological response rates achieved with current directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5-10% of treated patients do not respond to current antiviral therapies, and basal resistance to DAAs is increasingly detected among treatment-naïve infected individuals. [...]
2018 - 10.1186/s12879-018-3356-6
BMC Infectious diseases, Vol. 18 (september 2018)
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4.
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14 p, 3.2 MB |
Distribution and conservation of species is misestimated if biotic interactions are ignored : the case of the orchid Laelia speciosa
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Flores-Tolentino, Mayra (Universidad Michoacana de San Nicolás de Hidalgo) ;
García-Valdés, Raúl (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Saénz-Romero, Cuauhtémoc (Universidad Michoacana de San Nicolás de Hidalgo) ;
Ávila-Díaz, Irene (Universidad Michoacana de San Nicolás de Hidalgo) ;
Paz, Horacio (Universidad Nacional Autónoma de México) ;
Lopez-Toledo, Leonel (Universidad Michoacana de San Nicolás de Hidalgo)
The geographic distribution of species depends on their relationships with climate and on the biotic interactions of the species. Ecological Niche Models (ENMs) mainly consider climatic variables only and may tend to overestimate these distributions, especially for species strongly restricted by biotic interactions. [...]
2020 - 10.1038/s41598-020-63638-9
Scientific reports, Vol. 10 (June 2020) , art. 9542
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5.
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6.
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17 p, 1.9 MB |
Indel detection from Whole Genome Sequencing data and association with lipid metabolism in pigs
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Crespo-Piazuelo, Daniel (Centre de Recerca en Agrigenòmica) ;
Criado Mesas, Lourdes (Centre de Recerca en Agrigenòmica) ;
Revilla Sánchez, Manuel (Centre de Recerca en Agrigenòmica) ;
Castelló Farré, Anna (Centre de Recerca en Agrigenòmica) ;
Fernández Ávila, Ana Isabel (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya)) ;
Folch, Josep M. (Centre de Recerca en Agrigenòmica) ;
Ballester Devis, Maria (Institut de Recerca i Tecnologia Agroalimentàries)
The selection in commercial swine breeds for meat-production efficiency has been increasing among the past decades, reducing the intramuscular fat content, which has changed the sensorial and technological properties of pork. [...]
2019 - 10.1371/journal.pone.0218862
PloS one, Vol. 14, Núm. 6 (June 2019) , art. e0218862
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7.
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11 p, 1.9 MB |
Association between the pig genome and its gut microbiota composition
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Crespo-Piazuelo, Daniel (Centre de Recerca en Agrigenòmica) ;
Migura-Garcia, Lourdes (Institut de Recerca i Tecnologia Agroalimentàries) ;
Estellé, Jordi (Institut national de la recherche agronomique (França). Génétique Animale et Biologie Intégrative) ;
Criado Mesas, Lourdes (Centre de Recerca en Agrigenòmica) ;
Revilla Sánchez, Manuel (Centre de Recerca en Agrigenòmica) ;
Castelló Farré, Anna (Centre de Recerca en Agrigenòmica) ;
Muñoz, María (Centro I+D en Cerdo Ibérico INIA-Zafra) ;
García Casco, Juan M. (Centro I+D en Cerdo Ibérico INIA-Zafra) ;
Fernández Ávila, Ana Isabel (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya)) ;
Ballester Devis, Maria (Institut de Recerca i Tecnologia Agroalimentàries) ;
Folch, Josep M. (Centre de Recerca en Agrigenòmica)
The gut microbiota has been evolving with its host along the time creating a symbiotic relationship. In this study, we assess the role of the host genome in the modulation of the microbiota composition in pigs. [...]
2019 - 10.1038/s41598-019-45066-6
Scientific reports, Vol. 9 (June 2019) , art. 8791
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8.
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9.
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13 p, 1.8 MB |
Expression analysis of candidate genes for fatty acid composition in adipose tissue and identification of regulatory regions
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Revilla Sánchez, Manuel (Centre de Recerca en Agrigenòmica) ;
Puig-Oliveras, Anna (Centre de Recerca en Agrigenòmica) ;
Crespo-Piazuelo, Daniel (Centre de Recerca en Agrigenòmica) ;
Criado Mesas, Lourdes (Centre de Recerca en Agrigenòmica) ;
Castelló Farré, Anna (Centre de Recerca en Agrigenòmica) ;
Fernández Ávila, Ana Isabel (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya)) ;
Ballester Devis, Maria (Institut de Recerca i Tecnologia Agroalimentàries) ;
Folch, Josep M. (Centre de Recerca en Agrigenòmica)
The aim of this work was to study the genetic basis of the backfat expression of lipid-related genes associated with meat quality traits in pigs. We performed a genome-wide association study with the backfat gene expression measured in 44 genes by qPCR and the PorcineSNP60 BeadChip genotypes in 115 Iberian x Landrace backcross animals. [...]
2018 - 10.1038/s41598-018-20473-3
Scientific reports, Vol. 8 (February 2018) , art. 2045
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10.
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17 p, 839.2 KB |
Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus
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de la Higuera, Ignacio (Centro de Biología Molecular Severo Ochoa) ;
Ferrer-Orta, Cristina (Institut de Biologia Molecular de Barcelona) ;
de Ávila, Ana Isabel (Centro de Biología Molecular Severo Ochoa) ;
Perales Viejo, Celia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sierra, Macarena (Centro de Biología Molecular Severo Ochoa) ;
Singh, Kamalendra (Christopher S. Bond Life Sciences Center, University of Missouri) ;
Sarafianos, Stefan G. (Christopher S. Bond Life Sciences Center, University of Missouri) ;
Dehouck, Yves (Machine Learning Group, Université Libre de Bruxelles (ULB)) ;
Bastolla, Ugo (Centro de Biología Molecular Severo Ochoa) ;
Verdaguer, Nuria (Institut de Biologia Molecular de Barcelona) ;
Domingo, Esteban (Centro de Biología Molecular Severo Ochoa) ;
Universitat Autònoma de Barcelona
The selective pressures acting on viruses that replicate under enhanced mutation rates are largely unknown. Here, we describe resistance of foot-and-mouth disease virus to the mutagen 5-fluorouracil (FU) through a single polymerase substitution that prevents an excess of A to G and U to C transitions evoked by FU on the wild-type foot-and-mouth disease virus, while maintaining the same level of mutant spectrum complexity. [...]
2017 - 10.1093/gbe/evx075
Genome biology and evolution, Vol. 9 (may 2017) , p. 1212-1228
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