|
1.
|
|
34 p, 1.3 MB |
Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents : Kinetic characterization and effect on human cancer cells
/
Jiménez, Rafael (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Amor Minguez, Adrián (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Metwally, Kamel (Zagazig University. Department of Medicinal Chemistry) ;
Avilés, Francesc X (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aldehyde dehydrogenases (ALDHs) are enzymes catalyzing the NAD(P)+-dependent oxidation of aldehydes to their corresponding carboxylic acids. High ALDH activity has been related to some important features of cancer stem cells. [...]
2019 -  10.1016/j.cbi.2019.04.004
Chemico-Biological Interactions, Vol. 306 (2019) , p. 123-130
|
|
|
2.
|
|
12 p, 670.8 KB |
Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC
/
Meler-Claramonte, Carla (Institut d'Investigació Sanitària Pere Virgili) ;
Avilés-Jurado, Francesc Xavier (Agència de Gestió d'Ajuts Universitaris i de Recerca) ;
Vilaseca, Isabel (Universitat de Barcelona. Departament de Cirurgia i Especialitats Mèdicoquirúrgiques) ;
Terra, Ximena (Universitat Rovira i Virgili. Departament de Bioquímica i Biotecnologia) ;
Bragado, Paloma (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ;
Fuster, Gemma (Universitat de Barcelona. Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
León i Vintró, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Camacho, Mercedes (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The expression of the semaphorin-3F (SEMA3F) and neuropilin-2 (NRP2) is involved in the regulation of lymphangiogenesis. The present study analyzes the relationship between the transcriptional expression of the SEMA3F-NRP2 genes and the presence of occult lymph node metastases in patients with cN0 head and neck squamous cell carcinomas. [...]
2022 - 10.3390/cancers14092259
Cancers, Vol. 14, Núm. 9 (May 2022) , art. 2259
|
|
|
3.
|
|
37 p, 16.6 MB |
Marine Invertebrates : A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families
/
Pascual Alonso, Isel (University of Havana. Center for Protein Studies) ;
Almeida García, Fabiola (University of Havana. Center for Protein Studies) ;
Valdés Tresanco, Mario Ernesto (University of Calgary. Department of Biological Sciences) ;
Arrebola Sánchez, Yarini (University of Havana. Center for Protein Studies) ;
Ojeda del Sol, Daniel (University of Havana. Center for Protein Studies) ;
Sánchez Ramírez, Belinda (Centro de Inmunología Molecular) ;
Florent, Isabelle (Muséum National d'Histoire Naturelle) ;
Schmitt, Marjorie (Université de Strasbourg) ;
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes. [...]
2023 - 10.3390/md21050279
Marine drugs, Vol. 21, Issue 5 (April 2023) , art. 279
|
|
|
4.
|
|
17 p, 3.1 MB |
Isolation and Characterization of NpCI, a New Metallocarboxypeptidase Inhibitor from the Marine Snail Nerita peloronta with Anti- Plasmodium falciparum Activity
/
Cabrera-Muñoz, Aymara (Universidad de la Habana. Centro de Estudio de Proteínas) ;
Sierra-Gómez, Yusvel (Universidad de la Habana. Centro de Estudio de Proteínas) ;
Covaleda Cortés, Giovanni (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Reytor, Mey L. (Universidad de la Habana. Centro de Estudio de Proteínas) ;
González-González, Yamile (Universidad de la Habana. Centro de Estudio de Proteínas) ;
Bautista, José M. (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular) ;
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Alonso del Rivero, Maday (Universidad de la Habana. Centro de Estudio de Proteínas)
Metallocarboxypeptidases are zinc-dependent peptide-hydrolysing enzymes involved in several important physiological and pathological processes. They have been a target of growing interest in the search for natural or synthetic compound binders with biomedical and drug discovery purposes, i. [...]
2023 - 10.3390/md21020094
Marine drugs, Vol. 21 (january 2023)
|
|
|
5.
|
|
21 p, 2.6 MB |
Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly
/
Rodriguez-Calado, Sergi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Van Damme, Petra (Ghent University) ;
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Candiota Silveira, Ana Paula (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Tanco, Sebastián Martín (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The cytosolic carboxypeptidase 6 (CCP6) catalyzes the deglutamylation of polyglutamate side chains, a post-translational modification that affects proteins such as tubulins or nucleosome assembly proteins. [...]
2023 - 10.3390/ijms24021273
International journal of molecular sciences, Vol. 24, Issue 2 (January 2023) , art. 1273
|
|
|
6.
|
|
14 p, 2.0 MB |
Enhanced Production of ECM Proteins for Pharmaceutical Applications Using Mammalian Cells and Sodium Heparin Supplementation
/
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Montané, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Tanco, Sebastián Martín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The yields of soluble ECM proteins recombinantly produced with mammalian cells can be significantly enhanced by exploiting the stabilizing properties of heparin. Here, we propose a simple and straightforward scalable protocol for the mammalian cell production of ECM proteins with affinity for heparin, using heparin as a supplement. [...]
2022 - 10.3390/pharmaceutics14102138
Pharmaceutics, Vol. 14, Núm. 10 (October 2022) , art. 2138
|
|
|
7.
|
|
16 p, 1.7 MB |
Succinate Pathway in Head and Neck Squamous Cell Carcinoma : Potential as a Diagnostic and Prognostic Marker
/
Terra, Ximena (Universitat Rovira i Virgili) ;
Ceperuelo Mallafré, Victòria (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Merma Linares, Carla Vanessa (Universitat Rovira i Virgili) ;
Benaiges Moragrega, Ester (Universitat Rovira i Virgili) ;
Bosch Príncep, Ramon (Hospital de Tortosa Verge de la Cinta) ;
Castillo, Paola (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Flores, Joan Carles (Universitat Rovira i Virgili) ;
León i Vintró, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Valduvieco, Izaskun (Hospital Clínic i Provincial de Barcelona) ;
Basté, Neus (Hospital Clínic i Provincial de Barcelona) ;
Cámara, Marina (Hospital Clínic i Provincial de Barcelona) ;
Lejeune, Marylène (Hospital de Tortosa Verge de la Cinta) ;
Gumà, Josep (Institut d'Investigació Sanitària Pere Virgili) ;
Vendrell, Joan (Universitat Rovira i Virgili) ;
Vilaseca, Isabel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fernández-Veledo, Sonia (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Avilés-Jurado, Francesc Xavier (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Emerging evidence points to succinate as an important oncometabolite in cancer development; however, the contribution of the succinate-SUCNR1 axis to cancer progression remains unclear. Head and neck squamous cell carcinoma (HNSCC) is associated with disease and treatment-related morbidity so there is an urgent need for innovation in treatment and diagnosis practices. [...]
2021 - 10.3390/cancers13071653
Cancers, Vol. 13 (april 2021)
|
|
|
8.
|
|
13 p, 619.1 KB |
Use of dialysis, tracheostomy, and extracorporeal membrane oxygenation among 842,928 patients hospitalized with COVID-19 in the United States
/
Burn, Edward (Centre for Statistics in Medicine, University of Oxford) ;
Sena, Anthony G. (Department of Medical Informatics, Erasmus University Medical Center (Holanda)) ;
Prats-Uribe, Albert (University of Oxford. Centre for Statistics in Medicine) ;
Spotnitz, Matthew (Department of Biomedical Informatics, Columbia University) ;
DuVall, Scott (University of Utah School of Medicine) ;
Lynch, Kristine E. (Department of Internal Medicine, University of Utah School of Medicine) ;
Matheny, Michael E. (Department of Biomedical Informatics, Vanderbilt University Medical Center) ;
Nyberg, Fredrik (School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg) ;
Ahmed, Waheed-Ul-Rahman (College of Medicine and Health, University of Exeter) ;
Alser, Osaid (Massachusetts General Hospital (Boston)) ;
Alghoul, Heba (Faculty of Medicine, Islamic University of Gaza, Palestine) ;
Alshammari, Thamir (Medication Safety Research Chair, King Saud University) ;
Zhang, Lin (School of Population and Global Health, The University of Melbourne) ;
Casajust, Paula (Trial Form Support (Barcelona)) ;
Areia, Carlos (Nuffield Department of Clinical Neurosciences, University of Oxford) ;
Shah, Karishma (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre) ;
Reich, Christian (Real World Solutions (Estats Units d'Amèrica)) ;
Blacketer, Clair (Janssen Research & Development (Estats Units d'Amèrica)) ;
Andryc, Alan (Janssen Research & Development (Estats Units d'Amèrica)) ;
Fortin, Stephen (Janssen Research & Development (Estats Units d'Amèrica)) ;
Natarajan, Karthik (Department of Biomedical Informatics, Columbia University) ;
Gong, Mengchun (Southern Medical University, Guangzhou, China) ;
Golozar, Asieh (Johns Hopkins Bloomberg School of Public Health) ;
Morales, Daniel (Division of Population Health and Genomics, University of Dundee) ;
Rijnbeek, Peter (Department of Medical Informatics, Erasmus University Medical Center) ;
Subbian, Vignesh (College of Engineering, The University of Arizona, Tucson) ;
Roel, Elena (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Recalde, Martina (Universitat Autònoma de Barcelona) ;
Lane, Jennifer C. E. (Centre for Statistics in Medicine, University of Oxford) ;
Vizcaya, David (Bayer Pharmaceuticals (Barcelona)) ;
Posada, Jose D. (Department of Medicine, Stanford University) ;
Shah, Nigam H. (Department of Medicine, Stanford University) ;
Jonnagaddala, Jitendra (School of Public Health and Community Medicine (Austràlia)) ;
Lai, Lana Yin Hui (University of Manchester) ;
Avilés-Jurado, Francesc Xavier (Agència de Gestió d'Ajuts Universitaris i de Recerca) ;
Hripcsak, George (Department of Biomedical Informatics, Columbia University) ;
Suchard, Marc A. (Department of Biostatistic, UCLA Fielding School of Public Health, University of California) ;
Ranzani, Otavio T. (Pulmonary Division, Heart Institute Universidade de Sao Paulo) ;
Ryan, Patrick (Columbia University) ;
Prieto-Alhambra, Daniel (Centre for Statistics in Medicine, University of Oxford) ;
Kostka, Kristin (Real World Solutions (Estats Units d'Amèrica)) ;
Duarte-Salles, Talita 1985- (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
To estimate the proportion of patients hospitalized with COVID-19 who undergo dialysis, tracheostomy, and extracorporeal membrane oxygenation (ECMO). A network cohort study. Seven databases from the United States containing routinely-collected patient data: HealthVerity, Premier, IQVIA Hospital CDM, IQVIA Open Claims, Optum EHR, Optum SES, and VA-OMOP. [...]
2021 - 10.1101/2020.11.25.20229088
medRxiv, february 2021
|
|
|
9.
|
|
24 p, 3.9 MB |
Substrate specificity and structural modeling of human Carboxypeptidase Z : a unique protease with a Frizzled-like domain
/
Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Tanco, Sebastián Martín (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
García Guerrero, María del Carmen (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Dasgupta, Sayani (Albert Einstein College of Medicine. Department of Molecular Pharmacology) ;
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Fricker, Lloyd D. (Albert Einstein College of Medicine. Department of Molecular Pharmacology)
Metallocarboxypeptidase Z (CPZ) is a secreted enzyme that is distinguished from all other members of the M14 metallocarboxypeptidase family by the presence of an N-terminal cysteine-rich Frizzled-like (Fz) domain that binds Wnt proteins. [...]
2020 - 10.3390/ijms21228687
International journal of molecular sciences, Vol. 21, Issue 22 (November 2020) , art. 8687
|
|
|
10.
|
|
visitante ::
identificación
alerta personal vía correo electrónico o subscríbase al 
canal RSS.
