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14 p, 1.9 MB |
Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma
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Frontzek, Fabian (University Hospital of Münster (Alemanya)) ;
Staiger, Annette M. (Robert Bosch Hospital) ;
Zapukhlyak, Myroslav (University Hospital of Münster (Alemanya)) ;
Xu, Wendan (University Hospital of Münster (Alemanya)) ;
Bonzheim, Irina (University Hospital of Tübingen (Alemanya)) ;
Borgmann, Vanessa (University Hospital of Tübingen (Alemanya)) ;
Sander, Philip (University Hospital of Tübingen (Alemanya)) ;
Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Heming, Jan-Niklas (University Hospital of Münster (Alemanya)) ;
Berning, Philipp (University Hospital of Münster (Alemanya)) ;
Wullenkord, Ramona (University Hospital of Münster (Alemanya)) ;
Erdmann, Tabea (University Hospital of Münster (Alemanya)) ;
Lutz, Mathias (University Hospital of Münster (Alemanya)) ;
Veratti, Pia (University Hospital Freiburg) ;
Ehrenfeld, Sophia (University of Freiburg) ;
Wienand, Kirsty (University Medical Center Göttingen) ;
Horn, Heike (Robert Bosch Hospital) ;
Goodlad, John R. (Queen Elizabeth University Hospital) ;
Wilson, Matthew R. (Beatson West of Scotland Cancer Centre (Glasgow, Regne Unit)) ;
Anagnostopoulos, Ioannis (Charité - Universitätsmedizin Berlin) ;
Lamping, Mario (Charité - Universitätsmedizin Berlin) ;
González Barca, Eva (Universitat de Barcelona) ;
Climent, Fina (Institut d'Investigació Biomèdica de Bellvitge) ;
Salar, Antonio (Hospital del Mar (Barcelona, Catalunya)) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Abrisqueta, Pau (Hospital Universitari Vall d'Hebron) ;
Menarguez, Javier (Hospital General Universitario Gregorio Marañón) ;
Aldámiz-Echevarría, T (Hospital General Universitario Gregorio Marañón) ;
Richter, Julia (Christian-Albrechts-University) ;
Klapper, Wolfram (Christian-Albrechts-University) ;
Tzankov, Alexander (University Hospital Basel (Basilea, Suïssa)) ;
Dirnhofer, Stefan (University Hospital Basel (Basilea, Suïssa)) ;
Rosenwald, Andreas (University of Würzburg) ;
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lenz, Peter (Department of Physics. University of Marburg) ;
Miething, C. (German Cancer Research Center) ;
Hartmann, Wolfgang (University Hospital of Münster (Alemanya)) ;
Chapuy, Björn (University Medical Center Göttingen) ;
Fend, Falko (University Hospital of Tübingen (Alemanya)) ;
Ott, Gustav (Department of Clinical Pathology. Robert Bosch Hospital) ;
Navarro, José-Tomás (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Grau, Michael (University Hospital of Münster (Alemanya)) ;
Lenz, Georg (University Hospital of Münster (Alemanya)) ;
Universitat Autònoma de Barcelona
Plasmablastic lymphoma (PBL) represents a rare and aggressive lymphoma subtype frequently associated with immunosuppression. Clinically, patients with PBL are characterized by poor outcome. The current understanding of the molecular pathogenesis is limited. [...]
2021 -  10.1038/s41467-021-25405-w
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 5183
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15 p, 1.3 MB |
Genetic and phenotypic characterisation of HIV-associated aggressive B-cell non-Hodgkin lymphomas, which do not occur specifically in this population : diagnostic and prognostic implications
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Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muñoz-Marmol, Ana Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muncunill Farreny, Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García, Olga (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Montoto, Silvia (Centre for Haemato-Oncology. Barts Cancer Institute. Queen Mary University of London) ;
Gribben, John G. (Centre for Haemato-Oncology. Barts Cancer Institute. Queen Mary University of London) ;
Calaminici, Maria (Centre for Haemato-Oncology. Barts Cancer Institute. Queen Mary University of London) ;
Martinez, Antonio (Hospital Clínic i Provincial de Barcelona) ;
Veloza, Luis (Hospital Clínic i Provincial de Barcelona) ;
Martínez-Trillos, Alejandra (Hospital Clínic i Provincial de Barcelona) ;
Aldámiz-Echevarría, T (Hospital General Universitario Gregorio Marañón) ;
Menarguez, Javier (Hospital General Universitario Gregorio Marañón) ;
Terol, Maria José (Hospital Clínic Universitari (València)) ;
Ferrandez, Antonio (Hospital Clínic Universitari (València)) ;
Alcoceba, Miguel (Hospital Universitario de Salamanca) ;
Briones Meijide, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Gonzalez-Barca, Eva (Hospital Duran i Reynals (Hospitalet del Llobregat)) ;
Climent, Fina (Institut d'Investigació Biomèdica de Bellvitge) ;
Muntañola, Ana (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Moraleda, José Maria (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Abrisqueta, Pau (Hospital Universitari Vall d'Hebron) ;
Abella Monreal, Eugenia (Hospital del Mar (Barcelona, Catalunya)) ;
Colomo, Luis (Hospital del Mar (Barcelona, Catalunya)) ;
García-Ballesteros, Carlos (Hospital Arnau de Vilanova (València)) ;
Garcia-Caro, Montserrat (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Sancho, Juan-Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribera, José Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Navarro, José-Tomás (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The frequency of aggressive subtypes of B-cell non-Hodgkin lymphoma (B-NHL), such as high-grade B-cell lymphomas (HGBL) with MYC and BCL2 and/or BCL6 rearrangement (HGBL-DH/TH) or Burkitt-like lymphoma (BL) with 11q aberration, is not well known in the HIV setting. [...]
2022 - 10.1111/his.14798
Histopathology, 2022
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7 p, 894.3 KB |
The Truncated Isoform of Somatostatin Receptor5 (sst5TMD4) Is Associated with Poorly Differentiated Thyroid Cancer
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Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Luque, Raúl M. (Instituto Maimónides de Investigación Biomédica de Córdoba) ;
Reverter, Jordi L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Sánchez, Laura M. (Instituto Maimónides de Investigación Biomédica de Córdoba) ;
Gahete, Manuel D. (Instituto Maimónides de Investigación Biomédica de Córdoba) ;
Culler, Michael D. (IPSEN, Milford, Massachusetts, United States of America) ;
Díaz-Soto, Gonzalo (Hospital Clínico Universitario de Valladolid) ;
Lomeña, Francisco (Hospital Clínic i Provincial de Barcelona) ;
Squarcia, Mattia (Hospital Clínic i Provincial de Barcelona) ;
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mora, Mireia (Hospital Clínic i Provincial de Barcelona) ;
Fernández-Cruz, Laureano (Hospital Clínic i Provincial de Barcelona) ;
Vidal, Oscar (Hospital Clínic i Provincial de Barcelona) ;
Alastrue Vidal, Antonio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Balibrea Del Castillo, José María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Halperin, Irene (Hospital Clínic i Provincial de Barcelona) ;
Mauricio Puente, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castaño, Justo P. (Instituto Maimónides de Investigación Biomédica de Córdoba) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Somatostatin receptors (ssts) are expressed in thyroid cancer cells, but their biological significance is not well understood. The aim of this study was to assess ssts in well differentiated (WDTC) and poorly differentiated thyroid cancer (PDTC) by means of imaging and molecular tools and its relationship with the efficacy of somatostatin analog treatment. [...]
2014 - 10.1371/journal.pone.0085527
PloS one, Vol. 9 (january 2014)
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11 p, 1.9 MB |
Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma
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Recasens-Zorzo, Clara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cardesa-Salzmann, Teresa (Hospital Clínic i Provincial de Barcelona) ;
Petazzi, Paolo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ros-Blanco, Laia (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ;
Esteve-Arenys, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Clot, Guillem (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Guerrero-Hernández, Martina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rodríguez, Vanina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Soldini, Davide (Hospital Clínic i Provincial de Barcelona) ;
Valera, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Moros, Alexandra (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Climent, Fina (Hospital Universitari de Bellvitge) ;
Gonzalez-Barca, Eva (Institut Català d'Oncologia) ;
Mercadal, Santiago (Institut Català d'Oncologia) ;
Arenillas, Leonor (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Calvo, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gutiérrez-García, Gonzalo (Hospital Clínic i Provincial de Barcelona) ;
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ;
Sanjuan-Pla, Alejandra (Hospital Universitari i Politècnic La Fe (València)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez, Antonio (Hospital Clínic i Provincial de Barcelona) ;
Colomer, Dolors (Hospital Clínic i Provincial de Barcelona) ;
Estrada Tejedor, Roger (Universitat Ramon Llull) ;
Teixidó, Jordi (Universitat Ramon Llull) ;
Campo, Elias (Hospital Clínic i Provincial de Barcelona) ;
López-Guillermo, A. (Hospital Clínic i Provincial de Barcelona) ;
Borrell, José Ignacio (Universitat Ramon Llull) ;
Colomo, Luis (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pérez-Galán, Patricia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Roué, Gaël (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
Constitutive activation of the chemokine receptor CXCR4 has been associated with tumor progression, invasion, and chemotherapy resistance in different cancer subtypes. Although the CXCR4 pathway has recently been suggested as an adverse prognostic marker in diffuse large B-cell lymphoma, its biological relevance in this disease remains underexplored. [...]
2019 - 10.3324/haematol.2017.180505
Haematologica, Vol. 104 Núm. 4 (31 2019) , p. 778-788
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13 p, 2.1 MB |
Assessment of a New ROS1 Immunohistochemistry Clone (SP384) for the Identification of ROS1 Rearrangements in Patients with Non-Small Cell Lung Carcinoma : the ROSING Study
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Conde, Esther (Hospital Universitario HM Sanchinarro (Madrid)) ;
Hernández, Susana (Hospital Universitario HM Sanchinarro (Madrid)) ;
Martinez, Rebeca (Hospital Universitario HM Sanchinarro (Madrid)) ;
Angulo, Bárbara (Hospital Universitario HM Sanchinarro (Madrid)) ;
de Castro, Javier (Hospital Universitario La Paz (Madrid)) ;
Collazo-Lorduy, Ana (Hospital Universitario HM Sanchinarro (Madrid)) ;
Jimenez, Beatriz (Hospital Universitario HM Sanchinarro (Madrid)) ;
Muriel, Alfonso (Hospital Universitario Ramón y Cajal (Madrid)) ;
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aranda, Ignacio (Instituto de Investigación Sanitaria y Biomédica de Alicante) ;
Massuti, Bartomeu (Instituto de Investigación Sanitaria y Biomédica de Alicante) ;
Rojo, Federico (Centro de Investigación Biomédica en Red de Cáncer) ;
Dómine Gómez, Manuel (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Sansano, Irene (Hospital Universitari Vall d'Hebron) ;
Garcia, Felip (Quironsalud Hospital) ;
Felip, Enriqueta (Hospital Universitari Vall d'Hebron) ;
Mancheño, Nuria (Hospital Universitari i Politècnic La Fe (València)) ;
Juan, Óscar (Hospital Universitari i Politècnic La Fe (València)) ;
Sanz, Julián (Hospital Clínico San Carlos (Madrid)) ;
Gonzalez-Larriba, José Luis (Hospital Clínico San Carlos (Madrid)) ;
Atienza-Cuevas, Lidia (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Arriola-Arellano, Esperanza (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Abdulkader, Ihab (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Garcia-Gonzalez, Jorge (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Camacho, Carmen (Insular Materno-Infantil University Hospital Complex) ;
Rodríguez-Abreu, Delvys (Insular Materno-Infantil University Hospital Complex) ;
Teixidó, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Gonzalez-Piñeiro, Ana (Hospital Álvaro Cunqueiro (Vigo)) ;
Lázaro, Martín (Hospital Álvaro Cunqueiro (Vigo)) ;
Lozano, María Dolores (Clínica Universidad de Navarra) ;
Gurpide, Alfonso (Clínica Universidad de Navarra) ;
Gómez-Román, Javier (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Lopez-Brea, M. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Pijuan, Lara (Hospital del Mar (Barcelona, Catalunya)) ;
Salido, Marta (Hospital del Mar (Barcelona, Catalunya)) ;
Arriola, Edurne (Hospital del Mar (Barcelona, Catalunya)) ;
Company, Amparo (Hospital Clínic Universitari (València)) ;
Insa, Amelia (Hospital Clínic Universitari (València)) ;
Esteban-Rodriguez, Isabel (Hospital Universitario La Paz (Madrid)) ;
Saiz, Mónica (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Azkona, Eider (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Álvarez, Ramiro (Hospital Universitario Miguel Servet (Saragossa)) ;
Artal, Ángel (Hospital Universitario Miguel Servet (Saragossa)) ;
Plaza, María Luz (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Aguiar de Sousa, Diana (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Enguita, Ana Belén (Hospital Universitario 12 de Octubre (Madrid)) ;
Benito, Amparo (Hospital Universitario Ramón y Cajal (Madrid)) ;
Paz-Ares, Luis (Hospital Universitario 12 de Octubre (Madrid)) ;
Garrido, Pilar (Centro de Investigación Biomédica en Red de Cáncer) ;
Lopez-Rios, Fernando (Hospital Universitario HM Sanchinarro (Madrid)) ;
Universitat Autònoma de Barcelona
Introduction: The ROS1 gene rearrangement has become an important biomarker in NSCLC. The College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology testing guidelines support the use of ROS1 immunohistochemistry (IHC) as a screening test, followed by confirmation with fluorescence in situ hybridization (FISH) or a molecular test in all positive results. [...]
2019 - 10.1016/j.jtho.2019.07.005
Journal of Thoracic Oncology, Vol. 14 Núm. 12 (december 2019) , p. 2120-2132
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10 p, 579.1 KB |
Approach to amoebic colitis : Epidemiological, clinical and diagnostic considerations in a non-endemic context (Barcelona, 2007-2017)
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Roure, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valerio, L. (Institut Català de la Salut) ;
Soldevila Langa, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Salvador, Fernando (Hospital Universitari Vall d'Hebron) ;
Fernandez Rivas, Gema (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron) ;
Mañosa i Ciria, Míriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sopena, Nieves (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mate Sanz, Jose Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Background Amoebic colitis is the most frequent clinical manifestation of invasive intestinal infection due to Entamoeba histolytica and a common cause of diarrhoea worldwide. Since higher transmission rates are usually related to poor health and exposure to unhygienic conditions, cases reported in Europe usually involve immigrants and international travellers. [...]
2019 - 10.1371/journal.pone.0212791
PloS one, Vol. 14 Núm. 2 (february 2019) , p. e0212791
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6 p, 1.9 MB |
Heart-lung-muscle anti-SAE syndrome : an atypical severe combination
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Zamora, Elisabet (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Seder Colomina, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Holgado Pérez, Susana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quirant, Bibiana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mate Sanz, José Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Casafont Solé, Ivette (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. [...]
2019 - 10.3390/jcm8010020
Journal of clinical medicine, Vol. 8, issue 1 (Jan. 2019) , art. 20
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