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9 p, 536.9 KB |
Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome : Study protocol for a randomized controlled trial
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Bellingan, Geoff (University College London Hospitals) ;
Brealey, David (University College London Hospitals) ;
Mancebo, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Mercat, Alain (CHU D'Angers) ;
Patroniti, Nicolò (Azienda Ospedaliera San Gerardo) ;
Pettilä, Ville (Helsinki University Hospital) ;
Quintel, Michael (Universitätsmedizin Göttingen) ;
Vincent, Jean-Louis (Université libre de Bruxelles) ;
Maksimow, Mikael (Faron Pharmaceuticals Oy) ;
Jalkanen, Markku (Faron Pharmaceuticals Oy) ;
Piippo, Ilse (Faron Pharmaceuticals Oy) ;
Ranieri, V.Marco (Sapienza University of Rome) ;
Universitat Autònoma de Barcelona
Acute respiratory distress syndrome (ARDS) results in vascular leakage, inflammation and respiratory failure. There are currently no approved pharmacological treatments for ARDS and standard of care involves treatment of the underlying cause, and supportive care. [...]
2017 -  10.1186/s13063-017-2234-7
Trials, Vol. 18 Núm. 1 (13 2017) , p. 536
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45 p, 4.6 MB |
The European guideline on management of major bleeding and coagulopathy following trauma : sixth edition
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Rossaint, Rolf (Aachen University) ;
Afshari, Arash (University of Copenhagen) ;
Bouillon, Bertil (University of Witten/Herdecke) ;
Cerny, Vladimir (Charles University Faculty of Medicine) ;
Cimpoesu, Diana (University of Medicine and Pharmacy "Grigore T. Popa" Iasi) ;
Curry, Nicola (Oxford University) ;
Duranteau, Jacques (Paris Saclay University) ;
Filipescu, Daniela (Carol Davila University of Medicine and Pharmacy) ;
Grottke, Oliver (University Hospital Aachen (Alemanya)) ;
Grønlykke, Lars (University of Copenhagen) ;
Harrois, Anatole (Paris Saclay University) ;
Hunt, Beverley J. (Guy's and St Thomas' NHS Foundation Trust) ;
Kaserer, Alexander (University Hospital Zurich (Suïssa)) ;
Komadina, Radko (Ljubljana University) ;
Madsen, Mikkel Herold (University of Copenhagen) ;
Maegele, Marc (University of Witten/Herdecke.) ;
Mora, Lidia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riddez, Louis (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Romero, Carolina S. (UConsorcio Hospital General Universitario de Valencia) ;
Samama, Charles-Marc (Université Paris Cité) ;
Vincent, Jean-Louis (Université Libre de Bruxelles) ;
Wiberg, Sebastian (University of Copenhagen) ;
Spahn, Donat R. (University Hospital Zurich (Suïssa)) ;
Universitat Autònoma de Barcelona
Severe trauma represents a major global public health burden and the management of post-traumatic bleeding continues to challenge healthcare systems around the world. Post-traumatic bleeding and associated traumatic coagulopathy remain leading causes of potentially preventable multiorgan failure and death if not diagnosed and managed in an appropriate and timely manner. [...]
2023 - 10.1186/s13054-023-04327-7
Critical Care, Vol. 27 (march 2023)
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13 p, 993.7 KB |
Advances in antibiotic therapy in the critically ill
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Vincent, Jean-Louis (Université libre de Bruxelles) ;
Bassetti, Matteo (Santa Maria Misericordia University Hospital) ;
François, Bruno (Service de Réanimation Polyvalente (França)) ;
Karam, George (Louisiana State University School of Medicine (Estats Units d'Amèrica)) ;
Chastre, Jean (Groupe Hospitalier Pitié-Salpêtrière) ;
Torres, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Roberts, Jason A. (The University of Queensland) ;
Taccone, Fabio Silvio (Université libre de Bruxelles) ;
Rello, Jordi (Hospital Universitari Vall d'Hebron) ;
Calandra, Thierry (University of Lausanne) ;
De Backer, Daniel (Université Libre de Bruxelles) ;
Welte, Tobias (Medizinische Hochschule) ;
Antonelli, Massimo (Catholic University of Rome) ;
Universitat Autònoma de Barcelona
Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high prevalence of antibiotic-resistant strains. [...]
2016 - 10.1186/s13054-016-1285-6
Critical Care, Vol. 20 (may 2016)
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9 p, 1.0 MB |
Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection
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Kellum, John A. (Department of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh School of Medicine, Pittsburgh, PA) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Gunnerson, Kyle J. (Departments of Emergency Medicine/Critical Care, Anesthesiology, Internal Medicine, Michigan Center for Integrative Research in Critical Care (MCIRCC), University of Michigan, Ann Arbor, MI) ;
Honore, Patrick M. (Department of Intensive Care Medicine, Brugmann University Hospital, Brussels, Belgium) ;
Kampf, J. Patrick (Astute Medical, Inc. (a bioMérieux company), San Diego, CA) ;
Kwan, Thomas (Astute Medical, Inc. (a bioMérieux company), San Diego, CA) ;
McPherson, Paul (Astute Medical, Inc. (a bioMérieux company), San Diego, CA) ;
Nguyen, H. Bryant (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Loma Linda University, Loma Linda, CA) ;
Rimmelé, Thomas (Department of Anesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France) ;
Shapiro, Nathan I. (Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA) ;
Shi, Jing (Walker BioSciences, Carlsbad, CA) ;
Vincent, Jean-Louis (Université Libre de Bruxelles) ;
Chawla, Lakhmir S. (Department of Medicine, Veterans Affairs Medical Center, San Diego, CA) ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is available in the text. Retrospective, international, Sapphire study. Academic Medical Center. Adults admitted to the ICU without evidence of acute kidney injury at time of enrollment. [...]
2021 - 10.1097/CCM.0000000000004845
Critical Care Medicine, Vol. 49 (january 2021) , p. e360-e368
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10 p, 642.7 KB |
Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis
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Honore, Patrick M. (Vrije Universiteit Amsterdam) ;
Nguyen, H. Bryant (Department of Medicine, Pulmonary and Critical Care Medicine and Department of Emergency Medicine, Loma Linda University, Loma Linda, CA) ;
Gong, Michelle (Division of Critical Care Medicine, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY) ;
Chawla, Lakhmir S. (Department of Medicine, Division of Intensive Care Medicine and Division of Nephrology, Veterans Affairs Medical Center, and Department of Anesthesiology and Critical Care Medicine, George Washington University Medical Center, Washington, DC) ;
Bagshaw, Sean M. (Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Shi, Jing (Walker Biosciences, Carlsbad, CA) ;
Joannes-Boyau, Olivier (Department of Anesthesiology and Critical Care Medicine 2, Hospital Haut Leveque, University of Bordeaux 2, Bordeaux, France) ;
Vincent, Jean-Louis (Université Libre de Bruxelles) ;
Kellum, John A. ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is available in the text. To examine the performance of the urinary biomarker panel tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission. [...]
2016 - 10.1097/CCM.0000000000001827
Critical Care Medicine, Vol. 44 (september 2016) , p. 1851-1860
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11 p, 838.8 KB |
Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia : a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)
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Welte, Tobias (Carl-Neuberg-Str. 1, 30625 Hannover, Germany) ;
Dellinger, R. Phillip (Cooper Medical School of Rowan University. Department of Medicine) ;
Ebelt, Henning (Universitätsklinikum Halle (Saale). Klinik und Poliklinik für Innere Medizin III) ;
Ferrer, Miguel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Opal, Steven M. (Rhode Island Hospital. Infectious Disease Division) ;
Singer, Mervyn (University College London. Bloomsbury Institute of Intensive Care Medicine) ;
Vincent, Jean-Louis (Erasme University Hospital. Department of Intensive Care) ;
Werdan, Karl (St. James's Hospital. Trinity Centre for Health Sciences) ;
Martin-Loeches, Ignacio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Almirall i Pujol, Jordi (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ignacio Ayestarán, Jose (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Nuding, Sebastian (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sirgo Rodríguez, Gonzalo (Hospital Universitari Joan XXIII de Tarragona) ;
Shankar-Hari, Manu (Guy's and St. Thomas' NHS Foundation Trust. Intensive Care Medicine) ;
Álvarez Lerma, Francisco (Hospital del Mar (Barcelona, Catalunya)) ;
Riessen, Reimer (Universitätsklinikum Tübingen. Internistische Intensivstation) ;
Sirvent, Josep-Maria (Hospital Universitari de Girona Doctor Josep Trueta) ;
Kluge, Stefan (Universitätsklinikum Hamburg-Eppendorf. Klinik für Intensivmedizin) ;
Zacharowski, Kai (Universitätsklinikum Frankfurt. Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie) ;
Bonastre Mora, Juan (Hospital Universitari i Politècnic La Fe (València)) ;
Lapp, Harald (Medizinische Klinik, Kardiologie und Intensivmedizin, Helios Klinikum Erfurt, Erfurt, Germany) ;
Wöbker, Gabriele (Klinik für Intensivmedizin, Helios Universitätsklinikum Wuppertal, Wuppertal, Germany) ;
Achtzehn, Ute (Klinikum Chemnitz gGmbH. Innere Medizin IV - Pneumologie) ;
Brealey, David (Critical Care Unit, NIHR University College London Hospitals Biomedical Research Centre, University College London Hospitals, NHS Foundation Trust, London, UK) ;
Kempa, Axel (Katharinenhospital, Stuttgart. Klinik für Allgemeine Innere Medizin) ;
Sánchez García, Miguel (Hospital Clínico San Carlos (Madrid)) ;
Brederlau, Jörg (Helios Klinikum Berlin-Buch, Klinik für Intensivmedizin) ;
Kochanek, Matthias (University Hospital of Cologne. Department I of Internal Medicine) ;
Reschreiter, Henrik Peer (Poole Hospital NHS Foundation Trust) ;
Wise, Matthew P. (Heath Park, Cardiff) ;
Belohradsky, Bernd H. (University Children's Hospital Munich) ;
Bobenhausen, Iris (Biotest AG) ;
Dälken, Benjamin (Biotest AG) ;
Dubovy, Patrick (Biotest AG) ;
Langohr, Patrick (Biotest AG) ;
Mayer, Monika (Biotest AG) ;
Schüttrumpf, Jörg (Biotest AG) ;
Wartenberg-Demand, Andrea (Biotest AG) ;
Wippermann, Ulrike (Biotest AG) ;
Wolf, Daniele (Biotest AG) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona)
The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, ~ 21% IgA, and ~ 56% IgG as add-on therapy for patients with severe community-acquired pneumonia (sCAP). [...]
2018 - 10.1007/s00134-018-5143-7
Intensive Care Medicine, Vol. 44 (april 2018) , p. 438-448
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13 p, 786.1 KB |
A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients
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Rello, Jordi (Hospital Universitari Vall d'Hebron) ;
Krenn, Claus-Georg (Medical University of Vienna) ;
Locker, Gottfried (Medical University of Vienna) ;
Pilger, Ernst (University Hospital Graz, Graz, Austria) ;
Madl, Christian (Medical University of Vienna) ;
Balica, Laura (Emergency Clinical Hospital Bucharest) ;
Dugernier, Thierry (Clinique St. Pierre, Ottignies, Belgium) ;
Laterre, Pierre-Francois (St. Luc University Hospital UCL, Université Catholique de Louvain, Brussels, Belgium) ;
Spapen, Herbert (University Hospital Vrije Universiteit Brussels, Brussels, Belgium) ;
Depuydt, Pieter (UZ Gent, Gent, Belgium) ;
Vincent, Jean-Louis (Université Libre de Bruxelles) ;
Bogár, Lajos (University of Pécs, Pécs, Hungary) ;
Szabó, Zsuzsanna (Uzsoki Hospital, Budapest, Hungary) ;
Völgyes, Barbara (Bajcsy Zsilinszky Hospital and Polyclinic, Budapest, Hungary) ;
Máñez, Rafael (Hospital Universitari de Bellvitge) ;
Çakar, Nahit (Istanbul University Capa Medical Faculty, Istanbul, Turkey) ;
Ramazanoglu, Atilla (Akdeniz University, Antalya, Turkey) ;
Topeli, Arzu (Hacettepe University Hospital, Ankara, Turkey) ;
Mastruzzo, Maria A. (Hospital Dr. Carlos Bocalandro, Buenos Aires, Argentina) ;
Jasovich, Abel (Sanatorio Güemes, Buenos Aires, Argentina) ;
Remolif, Christian G. (Hospital "Heroes de Malvinas", Buenos Aires, Argentina) ;
del Carmen Soria, Liliana (Hospital Central Mendoza, Ciudad de Mendoza, Argentina) ;
Andresen Hernandez, Max A. (Pontificia Universidad Católica de Chile) ;
Ruiz Balart, Carolina (Hospital Dr. Sótero del Rio, Santiago, Chile) ;
Krémer, Ildikó (Flor Ferenc County Hospital, Kistarcsa, Hungary) ;
Molnár, Zsolt (University of Szeged, Szeged, Hungary) ;
von Sonnenburg, Frank (University of Munich, Germany) ;
Lyons, Arthur (Walter Reed Army Institute of Research) ;
Joannidis, Michael (Medical University of Innsbruck, Innsbruck, Austria) ;
Burgmann, Heinz (Medical University of Vienna) ;
Welte, Tobias (Hannover Medical School, Hannover, Germany) ;
Klingler, Anton (Assign Data Management and Biostatistics GmbH, Innsbruck, Austria) ;
Hochreiter, Romana (Valneva Austria GmbH, Campus Vienna Biocenter 3, Vienna, Austria) ;
Westritschnig, Kerstin (Valneva Austria GmbH, Campus Vienna Biocenter 3, Vienna, Austria) ;
Universitat Autònoma de Barcelona
Currently, no vaccine against Pseudomonas is available. IC43 is a new, recombinant, protein (OprF/I)-based vaccine against the opportunistic pathogen, Pseudomonas aeruginosa, a major cause of serious hospital-acquired infections. [...]
2017 - 10.1186/s13054-017-1601-9
Critical Care, Vol. 21 (february 2017)
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49 p, 235.4 KB |
The Extended Prevalence of Infection in the ICU Study : EPIC II
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Vincent, Jean-Louis (Université Libre de Bruxelles) ;
Rello, Jordi (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Marshall, John (University of Toronto, St. Michael's Hospital, Interdepartmental Division of Critical Care Medicine, Department of Surgery) ;
Silva, Eliezer (Hospital Israelita Albert Einstein (Sao Paolo, Brasil)) ;
Anzueto, Antonio (University of Texas Health Science Center (San Antonio, USA), Department of Pulmonary/Critical Care) ;
Martin, Claude D. (Hôpital Nord (Marseille, France), Department of Anesthesiology ant Intensive Care) ;
Moreno, Rui (Hospital de St Antonio dos Capuchos (Lisbon, Portugal), Department of Intensive Care) ;
Lipman, Jeffrey (Royal Brisbane and Womens' Hospital (Herston, Australia), Department of Intensive Care) ;
Sakr, Yasser (Friedrich-Schiller University (Jena, Germany), Department of Anesthesiiology and Intensive Care) ;
Reinhart, Konrad (Friedrich-Schiller University (Jena, Germany), Department of Anesthesiiology and Intensive Care)
Context: Infection is a major cause of morbidity and mortality in intensive care units worldwide. However, there is still relatively little information about the global epidemiology of such infections. [...]
2009 - 10.1001/jama.2009.1754
JAMA, Vol. 302, Núm. 21 (2009) , p. 1-49
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