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Results overview: Found 4 records in 0.02 seconds.
Articles, 3 records found
Research literature, 1 records found
Articles 3 records found  
1.
6 p, 2.1 MB Biocatalytic Aldol Addition of Simple Aliphatic Nucleophiles to Hydroxyaldehydes / Roldán, Raquel (Institut de Química Avançada de Catalunya) ; Hernández, Karel (Institut de Química Avançada de Catalunya) ; Joglar, Jesús (Institut de Química Avançada de Catalunya) ; Bujons, Jordi (Institut de Química Avançada de Catalunya) ; Parella Coll, Teodor (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ; Sánchez-Moreno, Israel (University Clermont Auvergne, CNRS, SIGMA Clermont) ; Hélaine, Virgil (University Clermont Auvergne, CNRS, SIGMA Clermont) ; Lemaire, Marielle (University Clermont Auvergne, CNRS, SIGMA Clermont) ; Guérard-Hélaine, Christine (University Clermont Auvergne, CNRS, SIGMA Clermont) ; Fessner, Wolf-Dieter (Technische Universität Darmstadt) ; Clapés, Pere (Institut de Química Avançada de Catalunya)
Asymmetric aldol addition of simple aldehydes and ketones to electrophiles is a cornerstone reaction for the synthesis of unusual sugars and chiral building blocks. We investigated -fructose-6-phosphate aldolase from E. [...]
2018 - 10.1021/acscatal.8b02486
ACS catalysis, Vol. 8 (08 2018) , p. 8804-8809  
Detailed record - Creative Commons
2.
15 p, 3.1 MB Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes / Roldán, Raquel (Institut de Química Avançada de Catalunya) ; Hernández, Karel (Institut de Química Avançada de Catalunya) ; Joglar, Jesús (Institut de Química Avançada de Catalunya) ; Bujons, Jordi (Institut de Química Avançada de Catalunya) ; Parella Coll, Teodor (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ; Fessner, Wolf-Dieter (Technische Universität Darmstadt) ; Clapés, Pere (Institut de Química Avançada de Catalunya)
Nitrogen heterocycles are structural motifs found in many bioactive natural products and of utmost importance in pharmaceutical drug development. In this work, a stereoselective synthesis of functionalized N-heterocycles was accomplished in two steps, comprising the biocatalytic aldol addition of ethanal and simple aliphatic ketones such as propanone, butanone, 3-pentanone, cyclobutanone, and cyclopentanone to N -Cbz-protected aminoaldehydes using engineered variants of -fructose-6-phosphate aldolase from Escherichia coli (FSA) or 2-deoxy--ribose-5-phosphate aldolase from Thermotoga maritima (DERA) as catalysts. [...]
2019 - 10.1002/adsc.201801530
Advanced synthesis & catalysis, Vol. 361, Issue 11 (January 2019) , p. 2673-2687  
Detailed record - Creative Commons
3.
24 p, 1.8 MB Simulation and prediction of protein production in fed-batch E. coli cultures : an engineering approach / Calleja Martínez, Daniel (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Kavanagh, John (The University of Sydney. School of Chemical and Biomolecular Engineering) ; Mas i Rocabayera, Carles de (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; López Santín, Josep (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
An overall model describing the dynamic behavior of fed-batch E. coli processes for protein production has been built, calibrated and validated. Using a macroscopic approach, the model consists of three interconnected blocks allowing simulation of biomass, inducer and protein concentration profiles with time. [...]
2016 - 10.1002/bit.25842
Biotechnology and bioengineering, Vol. 113, No. 4 (April 2016) , p. 772-782  
Detailed record -

Research literature 1 records found  
1.
223 p, 8.7 MB Chloroperoxidase and D-fructose-6-phosphate aldolase in enzymatic cascade reactions for the synthesis of iminocyclitols / Masdeu Gámez, Gerard ; López Santín, Josep, dir. (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Álvaro, Gregorio, dir. ; Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental
Aquest treball de tesi se centra en la viabilitat d'una reacció en cascada formada per una peroxidasa i una aldolasa per a la síntesi d'iminociclitols, que són inhibidors de glicosidases amb un enorme potencial terapèutic en moltes malalties, alterant la glicosilació o el catabolisme de glicoproteïnes. [...]
This thesis work is focused on the feasibility of a peroxidase/aldolase cascade reaction for the synthesis of iminocyclitols, which are glycosidase inhibitors with enormous therapeutic potential in many diseases by altering the glycosylation or catabolism of glycoproteins. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2017.  
Detailed record - Creative Commons

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