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1.
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Small Non-Coding RNAs and Their Role in Locoregional Metastasis and Outcomes in Early-Stage Breast Cancer Patients
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Escuin i Borràs, Daniel (Institut de Recerca Sant Pau) ;
Bell, Olga (Institut de Recerca Sant Pau) ;
García-Valdecasas Vilanova, Bárbara (Institut de Recerca Sant Pau) ;
Clos Enríquez, Montserrat (Institut de Recerca Sant Pau) ;
Larrañaga, Itziar (Institut de Recerca Sant Pau) ;
López Vilaró, Laura (Institut de Recerca Sant Pau) ;
Mora, Josefina (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Andrés, Marta (Institut de Recerca Sant Pau) ;
Arqueros, Cristina (Institut de Recerca Sant Pau) ;
Barnadas i Molins, Agustí (Institut de Recerca Sant Pau) ;
Universitat Autònoma de Barcelona
Deregulation of small non-coding RNAs (sncRNAs) has been associated with the onset of metastasis. We evaluated the expression of sncRNAs in patients with early-stage breast cancer, performing RNA sequencing in 60 patients for whom tumor and sentinel lymph node (SLN) samples were available, and conducting differential expression, gene ontology, enrichment and survival analyses. [...]
2024 -  10.3390/ijms25073982
International journal of molecular sciences, Vol. 25 (april 2024)
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2.
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14 p, 7.4 MB |
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
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Llinàs-Arias, Pere (Institut d'Investigació Sanitària Illes Balears) ;
Ensenyat-Mendez, Miquel (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Íñiguez-Muñoz, Sandra (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Orozco, Javier I.J. (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA) ;
Valdez, Betsy (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA.) ;
Salomon, Matthew P. (University of Southern California, Los Angeles, USA) ;
Matsuba, Chikako (University of Southern California, Los Angeles, USA) ;
Solivellas-Pieras, Maria (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Bedoya-López, Andrés F. (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Sesé, Borja (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Mezger, Anja (Science for Life Laboratory, Solna, Sweden) ;
Ormestad, Mattias (Science for Life Laboratory, Solna, Sweden) ;
Unzueta, Fernando (Universitat de Barcelona) ;
Strand, Siri H. (Stanford University School of Medicine, Stanford, USA) ;
Boiko, Alexander D. (Samuel Oschin Comprehensive Cancer Institute, Los Angeles, USA) ;
Hwang, E.Shelley (Duke University School of Medicine, Durham, USA) ;
Cortés, Javier (Universidad Europea de Madrid) ;
DiNome, Maggie L. (Duke University School of Medicine, Durham, USA) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lupien, Mathieu (University of Toronto) ;
Marzese, Diego M. (Cancer Epigenetics Laboratory, Health Research Institute of the Balearic Islands (IdISBa))
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tumor invasion, which is the first step of the metastatic process. [...]
2023 - 10.1186/s12943-023-01906-8
Molecular cancer, Vol. 22 Núm. 1 (november 2023)
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3.
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19 p, 8.1 MB |
Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin
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Franco Valls, Héctor (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Tusquets Uxó, Elsa (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Sala, Laura (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Val, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peña, Raúl (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Iaconcig, Alessandra (International Centre for Genetic Engineering and Biotechnology (ICGEB)) ;
Villarino, Álvaro (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Jiménez Arriola, Martín (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Massó, Pere (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Eyras, Eduardo (John Curtin School of Medical Research. Australian National University) ;
Muro, Andrés F. (International Centre for Genetic Engineering and Biotechnology (ICGEB)) ;
Otero, Jorge (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Garcia de Herreros, Antonio (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Baulida, Josep (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM))
Background: As in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue homeostasis. Some soluble factors, such as TGFβ, potently modify the behavior of healthy stromal cells. [...]
2023 - 10.1186/s13058-023-01736-y
Breast cancer research, Vol. 25 Núm. 1 (december 2023) , p. 143
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4.
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13 p, 3.0 MB |
Defining the optimal sequence for the systemic treatment of metastatic breast cancer
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Albanell Mestres, Joan (Hospital del Mar (Barcelona, Catalunya)) ;
Barnadas i Molins, Agustí (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez, Leticia C. (Complejo Hospitalario Universitario de A Coruña) ;
López-Muñiz, José Ignacio Chacón (Hospital Virgen de la Salud (Toledo)) ;
Ciruelos, Eva (Hospital 12 de Octubre (Madrid)) ;
de Juan Ferre, Ana (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
del Barco Berrón, S. (Institut Català d'Oncologia) ;
Pérez, Y.F. (Hospital Universitario Central de Asturias) ;
Mata, J.G. (Hospital Santa María Nai en Ourense) ;
Palomo, A.G. (Complejo Asistencial de León) ;
Gregori, J.G. (Fundació Institut Valencià d'Oncologia) ;
Pardo, P.G. (Hospital Universitari Vall d'Hebron) ;
Mañas, J.J.I. (Complejo Hospitalario de Navarra) ;
Hernández, A.L. (Hospital Clínic Universitari (València)) ;
de Dueñas, E.M. (Consorci Hospitalari Provincial de Castelló) ;
Jáñez, N.M. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Murillo, S.M. (Hospital Universitari Arnau de Vilanova) ;
Bofill, J.S. (Hospital Universitario Nuestra Señora de Valme) ;
Auñón, P.Z. (Hospital Universitario La Paz (Madrid)) ;
Sanchez-Rovira, P. (Complejo Hospitalario de Jaén) ;
Universitat Autònoma de Barcelona
Metastatic breast cancer is a heterogeneous disease that presents in varying forms, and a growing number of therapeutic options makes it difficult to determine the best choice in each particular situation. [...]
2017 - 10.1007/s12094-016-1520-2
Clinical & Translational Oncology, Vol. 19 Núm. 2 (january 2017) , p. 149-161
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5.
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6 p, 255.0 KB |
Cumulative risk of breast cancer screening outcomes according to the presence of previous benign breast disease and family history of breast cancer : Supporting personalised screening
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Román, M. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Quintana Ruiz, Maria Jesús (Institut d'Investigació Biomèdica Sant Pau) ;
Ferrer, J. (Parc Hospitalari Martí i Julià) ;
Sala, M. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Castells, X. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Our aim was to assess the cumulative risk of false-positive screening results, screen-detected cancer, and interval breast cancer in mammography screening among women with and without a previous benign breast disease and a family history of breast cancer. [...]
2017 - 10.1038/bjc.2017.107
British Journal of Cancer, Vol. 116 Núm. 11 (23 2017) , p. 1480-1485
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6.
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8 p, 508.4 KB |
Biomarkers expression in benign breast diseases and risk of subsequent breast cancer : a case-control study
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Posso, Margarita (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Corominas, Josep (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Serrano, Laia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Román, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torá-Rocamora, Isabel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Domingo, Laia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Romero, Anabel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Quintana, M.J. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Vernet-Tomas, Maria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Baré i Mañas, Marisa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Vidal, Carmen (Institut Català d'Oncología) ;
Sánchez, Mar (Catalunya. Generalitat) ;
Saladié, Francina (Fundación Liga para la Investigación y Prevención del Cáncer (Tarragona, Catalunya)) ;
Natal, Carmen (Programa de Detección de Cáncer de Mama del Principado de Asturias) ;
Ferrer, Joan (Hospital de Santa Caterina (Salt, Girona)) ;
Servitja, Sonia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sala, Maria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Castells, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Burón, A. ;
Rodríguez-Arana, A. ;
Romero, A. ;
Vernet, M. ;
Andreu, Xavier ;
Milà, N. ;
López Vilaró, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Fernández-Somoano, A. ;
Galceran, J. ;
Espinàs, J.A. ;
Universitat Autònoma de Barcelona
Women with benign breast diseases (BBD) have a high risk of breast cancer. However, no biomarkers have been clearly established to predict cancer in these women. Our aim was to explore whether estrogen receptor (ER), progesterone receptor (PR), and Ki67 expression stratify risk of breast cancer in screened women with BBD. [...]
2017 - 10.1002/cam4.1080
Cancer Medicine, Vol. 6 Núm. 6 (june 2017) , p. 1482-1489
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22 p, 8.7 MB |
Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer
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Waryah, Charlene (University of Western Australia) ;
Cursons, Joseph (Monash University, Australia) ;
Foroutan, Momeneh (Department of Biochemistry and Molecular Biology. Monash University, Australia) ;
Pflueger, Christian (University of Western Australia) ;
Wang, Edina (University of Western Australia) ;
Molania, Ramyar (University of Melbourne, Australia) ;
Woodward, Eleanor (Harry Perkins Institute of Medical Research, Australia) ;
Sorolla, Anabel (University of Western Australia) ;
Wallis, Christopher (University of Western Australia) ;
Moses, Colette (University of Amsterdam, The Netherlands) ;
Glas, Irina (Harry Perkins Institute of Medical Research, Australia) ;
Magalhães, Leandro (University of Pará, Brazil) ;
Thompson, Erik W. (Queensland University of Technology, Brisbane, Australia) ;
Fearnley, Liam G. (University of Melbourne, Australia) ;
Chaffer, Christine L. (St Vincent's Clinical School. UNSW Medicine, Australia) ;
Davis, Melissa (University of Melbourne, Australia) ;
Papenfuss, Anthony T. (University of Melbourne, Australia) ;
Redfern, Andrew (University of Western Australia) ;
Lister, Ryan (The University of Western Australia) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blancafort, Pilar (University of Western Australia)
Epithelial-mesenchymal transition (EMT) is a reversible transcriptional program invoked by cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of EMT, driving disease recurrence in poor-outcome triple negative breast cancers (TNBCs). [...]
2023 - 10.1002/advs.202301802
Advanced science, Vol. 10 Núm. 22 (august 2023)
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26 p, 5.7 MB |
Influence of social determinants, lifestyle, emotional well-being and the use of unconventional therapies in breast cancer progression in a cohort of women in Barcelona : Protocol for the DAMA Cohort
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Puigpinós i Riera, Rosa (Institut d'Investigació Biomèdica Sant Pau) ;
Continente, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Serral, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Bargalló, Xavi (Universitat de Barcelona) ;
Doménech, Montserrat (Association of Women with Breast Cancer (Agata)) ;
Espinosa-Bravo, Martín (Hospital Universitari Vall d'Hebron) ;
Grau, Jaume (Universitat de Barcelona) ;
Macià, Francesc (Institut Hospital Del Mar d'Investigació Mèdica) ;
Manzanera, Rafael (MC Mutual) ;
Pla i Consuegra, Margarida (Universitat de Barcelona) ;
Quintana Ruiz, Maria Jesús (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Maria (Institut Municipal d'Investigacions Mèdiques) ;
Vidal, Eulalia (Universitat Ramon Llull) ;
Universitat Autònoma de Barcelona
Breast cancer continues to be the most commonly diagnosed cancer in women. Breast cancer survivors face numerous problems, especially after completing the first year of intense treatment. We present the protocol for an ongoing study to analyze the impact of a series of factors on breast cancer survival related to lifestyle, emotional well-being, and use of complementary and alternative medicine (CAM). [...]
2017 - 10.2196/resprot.7653
JMIR Research Protocols, Vol. 6 Núm. 12 (december 2017) , p. e249
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18 p, 1.4 MB |
Intensive follow-up for women with breast cancer : Review of clinical, economic and patient's preference domains through evidence to decision framework
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Lafranconi, Alessandra (European Commission. Joint Research Centre (JRC)) ;
Pylkkänen, Liisa (European Commission. Joint Research Centre (JRC)) ;
Deandrea, Silvia (European Commission. Joint Research Centre (JRC)) ;
Bramesfeld, Anke (European Commission. Joint Research Centre (JRC)) ;
Lerda, Donata (European Commission. Joint Research Centre (JRC)) ;
Neamtiu, Luciana (European Commission. Joint Research Centre (JRC)) ;
Saz-Parkinson, Zuleika (European Commission. Joint Research Centre (JRC)) ;
Posso, Margarita (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Rigau, David (Institut d'Investigació Biomèdica Sant Pau) ;
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Martinez-Zapata, Maria José (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Women treated for breast cancer are followed-up for monitoring of treatment effectiveness and for detecting recurrences at an early stage. The type of follow-up received may affect women's reassurance and impact on their quality of life. [...]
2017 - 10.1186/s12955-017-0779-5
Health and quality of life outcomes, Vol. 15 Núm. 1 (19 2017) , p. 206
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27 p, 258.9 KB |
Effects of diets high in corn oil or in extra virgin olive oil on oxidative stress in an experimental model of breast cancer
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Escrich Navarro, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Vela Sarrión, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Solanas i Garcia, Montserrat (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Moral Cabrera, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Experimental evidence highlights the importance of dietetic factors on breast cancer. In this work we aimed to analyze the effects two oils, corn oil (rich in n-6 polyunsaturated fatty acids -PUFA-) and extra virgin olive oil (EVOO), on oxidative stress in an animal model of breast carcinogenesis. [...]
2020 - 10.1007/s11033-020-05492-6
Molecular Biology Reports, Vol. 47 Núm. 7 (January 2020) , p. 4923-4932
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