1.
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12 p, 9.6 MB |
Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling
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Estupiñán, Óscar (Instituto Universitario de Oncología del Principado de Asturias) ;
Rey, Verónica (Instituto Universitario de Oncología del Principado de Asturias) ;
Tornín, Juan (Instituto Universitario de Oncología del Principado de Asturias) ;
Murillo, Dzohara (Instituto Universitario de Oncología del Principado de Asturias) ;
Gallego, Borja (Instituto Universitario de Oncología del Principado de Asturias) ;
Huergo, Carmen (Instituto Universitario de Oncología del Principado de Asturias) ;
Blanco-Lorenzo, Verónica (Hospital Universitario Central de Asturias) ;
Victoria González, M. (Universidad de Oviedo) ;
Rodríguez, Aida (Instituto Universitario de Oncología del Principado de Asturias) ;
Moris, Francisco (EntreChem SL, Oviedo) ;
González Miranda, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ayllon, Veronica (Universidad de Granada) ;
Ramos-Mejía, Verónica (Universidad de Granada) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez, René (Instituto Universitario de Oncología del Principado de Asturias)
Osteosarcomas are frequently associated to a poor prognosis and a modest response to current treatments. EC-8042 is a well-tolerated mithramycin analog that has demonstrated an efficient ability to eliminate tumor cells, including cancer stem cell subpopulations (CSC), in sarcomas. [...]
2023 - 10.1016/j.biopha.2023.114627
Biomedicine & pharmacotherapy, Vol. 162 (june 2023)
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2.
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34 p, 1.3 MB |
Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents : Kinetic characterization and effect on human cancer cells
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Jiménez, Rafael (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Amor Minguez, Adrián (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Metwally, Kamel (Zagazig University. Department of Medicinal Chemistry) ;
Avilés, Francesc X (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aldehyde dehydrogenases (ALDHs) are enzymes catalyzing the NAD(P)+-dependent oxidation of aldehydes to their corresponding carboxylic acids. High ALDH activity has been related to some important features of cancer stem cells. [...]
2019 - 10.1016/j.cbi.2019.04.004
Chemico-Biological Interactions, Vol. 306 (2019) , p. 123-130
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3.
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21 p, 985.0 KB |
Role of Moonlighting Proteins in Disease : Analyzing the Contribution of Canonical and Moonlighting Functions in Disease Progression
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Huerta Casado, Mario (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Franco Serrano, Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Amela Abellan, Isaac (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pérez-Pons, Josep A (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Mozo-Villarias, Angel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cedano Rodríguez, Juan Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The term moonlighting proteins refers to those proteins that present alternative functions performed by a single polypeptide chain acquired throughout evolution (called canonical and moonlighting, respectively). [...]
2023 - 10.3390/cells12020235
Cells, Vol. 12, Issue 2 (January 2023) , art. 235
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4.
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20 p, 7.0 MB |
Flow-cytometry-based protocols for human blood/marrow immunophenotyping with minimal sample perturbation
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G. Rico, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Salvia, Roser (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ward, Michael D. (Thermo Fisher Scientific) ;
Bradford, Jolene A. (Thermo Fisher Scientific) ;
Petriz, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
This protocol provides instructions to improve flow cytometry analysis of marrow/peripheral blood cells by avoiding erythrolytic solutions, density gradients, and washing steps. We describe two basic approaches for identifying cell surface antigens with minimal sample perturbation, which have been successfully used to identify healthy and pathologically rare cells. [...]
2021 - 10.1016/j.xpro.2021.100883
STAR Protocols, Vol. 2 Núm. 4 (17 2021) , art. 100883
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6.
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25 p, 4.8 MB |
Selectively Targeting Breast Cancer Stem Cells by 8-Quinolinol and Niclosamide
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Cámara-Sánchez, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Díaz Riascos, Zamira Vanessa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García Aranda, Natalia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gener, Petra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Giani-Alonso, Micaela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Royo, Miriam (Institut de Química Avançada de Catalunya) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Cancer maintenance, metastatic dissemination and drug resistance are sustained by cancer stem cells (CSCs). Triple negative breast cancer (TNBC) is the breast cancer subtype with the highest number of CSCs and the poorest prognosis. [...]
2022 - 10.3390/ijms231911760
International journal of molecular sciences, Vol. 23, Issue 19 (October 2022) , art. 11760
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7.
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8.
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20 p, 1.8 MB |
Extracellular Vesicles as Drug Delivery Systems in Cancer
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Hernandez-Oller, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Rafael, Diana (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Abasolo, Ibane (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Gener, Petra (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Schwartz, Simon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Universitat Autònoma de Barcelona
Within tumors, Cancer Stem Cell (CSC) subpopulation has an important role in maintaining growth and dissemination while preserving high resistance against current treatments. It has been shown that, when CSCs are eliminated, the surrounding Differentiated Cancer Cells (DCCs) may reverse their phenotype and gain CSC-like features to preserve tumor progression and ensure tumor survival. [...]
2020 - 10.3390/pharmaceutics12121146
Pharmaceutics, Vol. 12 (november 2020)
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9.
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20 p, 2.7 MB |
Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells
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Montero, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Universidade do Porto) ;
Martinez-Trucharte, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vilar-Hernández, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quesada, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Xandri Monje, Helena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rafael, Diana (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Schwartz, Simon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Universitat Autònoma de Barcelona
Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the condensin complex involved in DNA supercoiling, an essential process for embryonic stem cell survival. SMC2 over-expression has been related with tumorigenesis and cancer malignancy and its inhibition is regarded as a potential therapeutic strategy even though no drugs are currently available. [...]
2020 - 10.3390/pharmaceutics12020185
Pharmaceutics, Vol. 12 (february 2020)
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10.
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20 p, 4.5 MB |
TSPAN1 : a Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance
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Garcia Mayea, Yoelsis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mir Pérez, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carballo, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Temprana-Salvador, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lorente, Juan (Hospital Universitari Vall d'Hebron) ;
Benavente, Sergi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Pedrero, Juana María (Centro de Investigación Biomédica en Red de Cáncer) ;
Allonca, Eva (Centro de Investigación Biomédica en Red de Cáncer) ;
Rodrigo, Juan Pablo (Centro de Investigación Biomédica en Red de Cáncer) ;
LLeonart, Matilde E. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Sensitization of resistant cells and cancer stem cells (CSCs) represents a major challenge in cancer therapy. A proteomic study revealed tetraspanin-1 (TSPAN1) as a protein involved in acquisition of cisplatin (CDDP) resistance (Data are available via ProteomeXchange with identifier PXD020159). [...]
2020 - 10.3390/cancers12113269
Cancers, Vol. 12 Núm. 11 (2020) , p. 3269
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