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11 p, 379.4 KB |
Postoperative Chemotherapy Use and Outcomes From ADAURA : Osimertinib as Adjuvant Therapy for Resected EGFR-Mutated NSCLC
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Wu, Yi-Long (Guangdong Lung Cancer Institute) ;
John, Thomas (Austin Health) ;
Grohe, Christian (Evangelische Lungenklinik) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Goldman, Jonathan W. (University of California) ;
Kim, Sang-We (University of Ulsan) ;
Kato, Terufumi (Kanagawa Cancer Center) ;
Laktionov, Konstantin (Blokhin National Medical Research Center of Oncology) ;
Vu, Huu Vinh (Choray Hospital) ;
Wang, Zhije (Chinese Academy of Medical Sciences) ;
Lu, Shun (Shanghai Jiao Tong University) ;
Lee, Kye Young (Konkuk University Medical Center) ;
Akewanlop, Charuwan (Siriraj Hospital) ;
Yu, Chong-Jen (National Taiwan University College of Medicine) ;
de Marinis, Filippo (European Institute of Oncology) ;
Bonanno, Laura (Istituto Oncologico Veneto) ;
Domine, Manuel (Instituto de Investigación Sanitaria-Fundación Jiménez Díaz) ;
Shepherd, Frances A. (University of Toronto) ;
Zeng, Lingmin (AstraZeneca) ;
Atasoy, Ajlan (AstraZeneca) ;
Herbst, Roy S. (Yale School of Medicine) ;
Tsuboi, Masahiro (National Cancer Center Hospital East) ;
Universitat Autònoma de Barcelona
Introduction: Adjuvant chemotherapy is recommended in patients with resected stages II to IIIA (and select IB) NSCLC; however, recurrence rates are high. In the phase 3 ADAURA study (NCT02511106), osimertinib was found to have a clinically meaningful improvement in disease-free survival (DFS) in patients with resected stages IB to IIIA EGFR-mutated (EGFRm) NSCLC. [...]
2022 -  10.1016/j.jtho.2021.10.014
Journal of Thoracic Oncology, Vol. 17 Núm. 3 (march 2022) , p. 423-433
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6 p, 1.1 MB |
Corticosteroid tapering is a safe approach in patients with relapsed or refractory multiple myeloma receiving subcutaneous daratumumab : part 3 of the open-label, multicenter, phase 1b PAVO study
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Nahi, Hareth (Karolinska Institute. Department of Medicine) ;
Usmani, Saad Z. (Memorial Sloan Kettering Cancer Center) ;
Mateos, M. V (Hospital Universitario de Salamanca) ;
van de Donk, Niels W C J (Department of Hematology. Vrije Universiteit Amsterdam) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Plesner, Torben (Vejle Hospital and University of Southern Denmark) ;
Bandyopadhyay, Nibedita (Janssen Research & Development. LLC) ;
Hellemans, Peter (Janssen Research & Development) ;
Tromp, Brenda (Janssen Research & Development. LLC) ;
Nnane, Ivo (Janssen Research & Development. LLC) ;
Zemlickis, Donna (Janssen Research & Development. LLC) ;
Chari, Ajai (Icahn School of Medicine at Mount Sinai) ;
Moreau, Philippe (University Hospital Hôtel-Dieu (Nantes, França))
2023 - 10.1080/10428194.2022.2148221
Leukemia and Lymphoma, Vol. 64 Núm. 2 (2023) , p. 468-472
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13 p, 471.4 KB |
Overall Survival with Daratumumab, Lenalidomide, and Dexamethasone in Previously Treated Multiple Myeloma (POLLUX) : A Randomized, Open-Label, Phase III Trial
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Dimopoulos, Meletios (National and Kapodistrian University of Athens) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Nahi, Hareth (Department of Medicine. Karolinska University) ;
San-Miguel, J (Clínica Universidad de Navarra) ;
Bahlis, Nizar J. (University of Calgary) ;
Usmani, S. Z (Memorial Sloan Kettering Cancer Center) ;
Rabin, Neil (Department of Haematology. University College London Hospitals NHS Trust) ;
Orlowski, Robert Z. (Department of Lymphoma and Myeloma. The University of Texas) ;
Suzuki, Kenshi (Department of Hematology. Japanese Red Cross Medical Center) ;
Plesner, Torben (University of Southern Denmark) ;
Yoon, Sung Soo (Department of Internal Medicine. Seoul National University) ;
Ben Yehuda, Dina (Hematology Department. Hebrew University) ;
Richardson, Paul G. (Dana-Farber Cancer Institute (Estats Units d'Amèrica)) ;
Goldschmidt, Hartmut (Heidelberg University Hospital (Alemanya)) ;
Reece, Donna (Department of Medical Oncology and Hematology. Princess Margaret Cancer Centre) ;
Ahmadi, Tahamtan (Genmab US (Estats Units d'Amèrica)) ;
Qin, Xiang (Janssen Research & Development (Xina)) ;
Garvin Mayo, Wendy (Janssen Research & Development (Estats Units d'Amèrica)) ;
Gai, Xue (Janssen Research & Development (Estats Units d'Amèrica)) ;
Carey, Jodi (Janssen Research & Development (Estats Units d'Amèrica)) ;
Carson, Robin (Janssen Research & Development (Estats Units d'Amèrica)) ;
Moreau, Philippe (Hematology Department. University Hospital Hôtel-Dieu)
PURPOSEWith the initial analysis of POLLUX at a median follow-up of 13. 5 months, daratumumab in combination with lenalidomide and dexamethasone (D-Rd) significantly prolonged progression-free survival versus lenalidomide and dexamethasone (Rd) alone in patients with relapsed or refractory multiple myeloma (RRMM). [...]
2023 - 10.1200/JCO.22.00940
Journal of Clinical Oncology, Vol. 41 Núm. 8 (october 2023) , p. 1590-1599
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17 p, 1.2 MB |
Impact of Minimal Residual Disease on Progression-Free Survival Outcomes after Fixed-Duration Ibrutinib-Venetoclax Versus Chlorambucil-Obinutuzumab in the GLOW Study
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Munir, Talha (St James's Hospital) ;
Moreno, Carol (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Owen, Carolyn (Tom Baker Cancer Centre) ;
Follows, George (Addenbrookes Hospital (Cambridge, Regne Unit)) ;
Benjamini, Ohad (Sheba Medical Center) ;
Janssens, Ann (UZ Leuven Gasthuisberg) ;
Levin, Mark-David (Albert Schweitzer Hospital) ;
Osterborg, Anders (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Robak, Tadeusz (Medical University of Lodz. Copernicus Memorial Hospital) ;
Simkovic, Martin (University Hospital Hradec Kralove (República Txeca)) ;
Stevens, Don (Norton Cancer Institute) ;
Voloshin, Sergey (Russian Scientific and Research Institute of Hematology and Transfusiology) ;
Vorobyev, Vladimir (S.P. Botkin Moscow City Clinical Hospital) ;
Yagci, Munci (Gazi Universitesi Tip Fakultesi) ;
Ysebaert, Loic (Institut Universitaire du Cancer Toulouse Oncopole) ;
Qi, Keqin (Janssen Research & Development) ;
Qi, Qianya (Janssen Research & Development) ;
Parisi, Lori (Janssen Research & Development) ;
Srinivasan, Srinivasan (Oncology Translational Research. Janssen Research & Development) ;
Schuier, Natasha (Janssen Research & Development) ;
Baeten, Kurt (Janssen Research & Development) ;
Howes, Angela (Janssen Research & Development) ;
Caces, Donne Bennett (Janssen Research & Development) ;
Niemann, Carsten U (Rigshospitalet Copenhagen University Hospital) ;
Kater, Arnon P. (Amsterdam Medical Centers. University of Amsterdam)
PURPOSEIn GLOW, fixed-duration ibrutinib + venetoclax showed superior progression-free survival (PFS) versus chlorambucil + obinutuzumab in older/comorbid patients with previously untreated chronic lymphocytic leukemia (CLL). [...]
2023 - 10.1200/JCO.22.02283
Journal of Clinical Oncology, Vol. 41 Núm. 21 (20 2023) , p. 3689-3699
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10 p, 3.3 MB |
Feasibility and outcomes after dose reduction of immunochemotherapy in young adults with Burkitt lymphoma and leukemia : results of the BURKIMAB14 trial
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Ribera, Josep Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morgades, Mireia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Calduch, Olga (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sirvent, Maialen (Hospital Universitario de Donostia) ;
Buendia, Buenaventura (Hospital Universitario 12 de Octubre) ;
Cervera, Marta (Institut Catala d'Oncologia-Hospital Joan XXIII) ;
Luzardo, Hugo (Hospital Universitario de Gran Canaria Dr. Negrin) ;
Hernandez-Rivas, Jesus Maria (Hospital Universitario de Salamanca) ;
Sitges, Marta (Hospital Universitari de Girona Doctor Josep Trueta) ;
Garcia-Cadenas, Irene (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Abrisqueta, Pau (Hospital Universitari Vall d'Hebron) ;
Montesinos, Pau (Hospital Universitari i Politècnic La Fe (València)) ;
Bastos-Oreiro, Mariana (Hospital General Universitario Gregorio Marañón) ;
De Llano, Maria Paz Queipo (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Bravo, Pilar (Hospital Universitario de Fuenlabrada. Madrid) ;
Torrent, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Herrera, Pilar (Hospital Universitario Ramon y Cajal) ;
Garcia-Guinon, Antonni (Hospital Universitari Arnau de Vilanova) ;
Vall-Llovera, Ferran (Hospital Universitari MútuaTerrassa) ;
Serrano, Josefina (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
Terol, Maria José (Hospital Clinico Universitario de Valencia) ;
Bergua, Juan Miguel (Hospital San Pedro de Alcántara) ;
Garcia-Noblejas, Ana (Hospital Universitario de La Princesa) ;
Barrenetxea, Cristina (Hospital Universitario Basurto) ;
Llorente, Laura (Hospital Universitario HM Sanchinarro) ;
Garcia-Belmonte, Daniel (Hospital Universitario La Zarzuela) ;
Gimeno, Eva (Hospital del Mar (Barcelona, Catalunya)) ;
Cladera, Antonia (Hospital Universitari Son Llatzer) ;
Mercadal, Santiago (Institut Català d'Oncologia) ;
Sancho, Juan Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
High dose-intensive or infusional intermediate-dose immunochemotherapy is highly effective treatment for Burkitt lymphoma irrespective of human immunodeficiency virus (HIV) infection. However, toxicities of these regimens are relevant, especially in older adults and elderly patients. [...]
2024 - 10.3324/haematol.2023.283342
Haematologica, Vol. 109 Núm. 2 (january 2024) , p. 543-552
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9 p, 1.4 MB |
Predictive signature of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer integrating mRNA expression, taxonomic subtypes, and clinicopathological features
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Font, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domenech, Montserrat (Althaia Xarxa Assistencial Universitària de Manresa) ;
Ramirez, Jose Luis (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Marqués, Miriam (Centro Nacional de Investigaciones Oncológicas) ;
Benítez, Raquel (Centro Nacional de Investigaciones Oncológicas) ;
Ruiz de Porras, Vicenç (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gago, José L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sant, Francesc (Althaia Xarxa Assistencial Universitària de Manresa) ;
Lopez, Hector (Althaia Xarxa Assistencial Universitària de Manresa) ;
Castellano, Daniel (Hospital Universitario 12 de Octubre (Madrid)) ;
Malats, Núria (Centro Nacional de Investigaciones Oncológicas) ;
Calle, M. Luz (Universitat de Vic - Universitat Central de Catalunya) ;
Real, Francisco X. (Universitat Pompeu Fabra)
Background and objective: Neoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care in muscle-invasive bladder cancer (MIBC). Pathological response has been associated with longer survival, but no currently available clinicopathological variables can identify patients likely to respond, highlighting the need for predictive biomarkers. [...]
2023 - 10.3389/fonc.2023.1155244
Frontiers in Oncology, Vol. 13 (august 2023)
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17 p, 2.6 MB |
β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia
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García-Hernández, Violeta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Arambilet Mobilla, David (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guillén, Yolanda (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lobo-Jarne, Teresa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Maqueda, Maria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gekas, Christos (Institut Hospital del Mar d'Investigacions Mèdiques) ;
González Miranda, Jessica (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Iglesias, Arnau (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Vega-García, Nerea (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Sentís, Inés (Centre de Regulació Genòmica) ;
Trincado Alonso, Juan Luis, 1987- (Centre de Regulació Genòmica) ;
Márquez-López, Ian (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Camós, Mireia (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the evolution of T-cell Acute Lymphoblastic Leukemia (T-ALL) patients and its involvement in therapy resistance. [...]
2023 - 10.15252/emmm.202216554
EMBO Molecular Medicine, Vol. 15 Núm. 2 (february 2023)
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13 p, 3.0 MB |
Defining the optimal sequence for the systemic treatment of metastatic breast cancer
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Albanell Mestres, Joan (Hospital del Mar (Barcelona, Catalunya)) ;
Barnadas i Molins, Agustí (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez, Leticia C. (Complejo Hospitalario Universitario de A Coruña) ;
López-Muñiz, José Ignacio Chacón (Hospital Virgen de la Salud (Toledo)) ;
Ciruelos, Eva (Hospital 12 de Octubre (Madrid)) ;
de Juan Ferre, Ana (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
del Barco Berrón, S. (Institut Català d'Oncologia) ;
Pérez, Y.F. (Hospital Universitario Central de Asturias) ;
Mata, J.G. (Hospital Santa María Nai en Ourense) ;
Palomo, A.G. (Complejo Asistencial de León) ;
Gregori, J.G. (Fundació Institut Valencià d'Oncologia) ;
Pardo, P.G. (Hospital Universitari Vall d'Hebron) ;
Mañas, J.J.I. (Complejo Hospitalario de Navarra) ;
Hernández, A.L. (Hospital Clínic Universitari (València)) ;
de Dueñas, E.M. (Consorci Hospitalari Provincial de Castelló) ;
Jáñez, N.M. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Murillo, S.M. (Hospital Universitari Arnau de Vilanova) ;
Bofill, J.S. (Hospital Universitario Nuestra Señora de Valme) ;
Auñón, P.Z. (Hospital Universitario La Paz (Madrid)) ;
Sanchez-Rovira, P. (Complejo Hospitalario de Jaén) ;
Universitat Autònoma de Barcelona
Metastatic breast cancer is a heterogeneous disease that presents in varying forms, and a growing number of therapeutic options makes it difficult to determine the best choice in each particular situation. [...]
2017 - 10.1007/s12094-016-1520-2
Clinical & Translational Oncology, Vol. 19 Núm. 2 (january 2017) , p. 149-161
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10 p, 666.8 KB |
Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain
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Arriola, Edurne (Hospital del Mar (Barcelona, Catalunya)) ;
García Gómez, Ramón (Hospital General Universitario Gregorio Marañón) ;
Diz Taín, Pilar (Hospital Universitario de León) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez Aguillo, Maite (Complejo Hospitalario de Navarra) ;
Valdivia, Javier (Hospital Universitario Virgen de las Nieves (Granada)) ;
Paredes, Alfredo (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Sánchez-Torres, José Miguel (Hospital Universitario de la Princesa (Madrid)) ;
Peralta Muñoz, Sergio (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Barneto Aranda, Isidoro (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
Gutierrez, Vanesa (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Andrade Santiago, Jesús Manuel (Hospital Virgen de la Salud (Toledo)) ;
Aparisi, Francisco (Hospital Virgen de los Lirios) ;
Isla, Dolores (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Ponce, Santiago (Hospital 12 de Octubre (Madrid)) ;
Vicente Baz, David (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Artal, Ángel (Hospital Universitario Miguel Servet (Saragossa)) ;
Amador, Mariluz (AstraZeneca) ;
Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Universitat Autònoma de Barcelona
Although the benefit of first-line epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) over chemotherapy has been demonstrated in several clinical trials, data from clinical practice is lacking and the optimal EGFR TKI to be used remains unclear. [...]
2018 - 10.1186/s12885-018-4004-7
BMC Cancer, Vol. 18 Núm. 1 (30 2018) , p. 106
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