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9 p, 658.5 KB |
Breaking the unvirtuous cycle : barriers and opportunities for research and development in Paraguay. A case study
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González Donna, María Lucila (Instituto Nacional del Cáncer (Paraguay)) ;
León, María Luisa (Pathology Unit. Instituto Nacional del Cáncer. Ministerio de Salud Pública y Bienestar Social) ;
Colas, Cinthia Gauna (Instituto Nacional del Cáncer (Paraguay)) ;
Gunsett, Alicia Pomata (Instituto Nacional del Cáncer (Paraguay)) ;
Maniero, Silvia Ferreira Maniero (Instituto Nacional del Cáncer (Paraguay)) ;
Olivares Osuna, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Klimovsky, Ezequiel (QUID LATAM Consulting (Argentina)) ;
Coradini, Lucas (Family Medicine Resident. Hospital Argerich) ;
Enrico, Diego (Research Department. Equipo Transdisciplinario de Investigación en Cáncer (Argentina)) ;
Chacón, Matías (Research Department. Equipo Transdisciplinario de Investigación en Cáncer (Argentina)) ;
Waisberg, Federico (Research Department. Equipo Transdisciplinario de Investigación en Cáncer (Argentina))
Introduction: Medical research and development (R&D) is an undoubtedly relevant activity to drive innovation, improve healthcare policies and bring patients treatment opportunities for common and rare diseases. [...]
2023 -  10.3389/fmed.2023.1266246
Frontiers in Medicine, Vol. 10 (2023) , p. 1266246
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8 p, 316.8 KB |
Solid organ transplantation after hematopoietic stem cell transplantation in childhood : A multicentric retrospective survey
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Faraci, Maura (Istituto G Gaslini) ;
Bertaina, Alice (Stanford University) ;
Dalissier, Arnaud (European Society for Blood and Marrow Transplantation Pediatric Disease Working Party) ;
Ifversen, Marianne (Copenhagen University Hospital) ;
Schulz, Ansgar (University Medical Center) ;
Gennery, Andrew (Great North Children's Hospital) ;
Burkhardt, Birgit (University Hospital of Münster (Alemanya)) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Díaz de Heredia, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Lanino, Edoardo (Istituto G Gaslini) ;
Lankester, Arjan C. (Leiden University Medical Center) ;
Gruhn, Bernd (Jena University Hospital (Alemania)) ;
Matthes-Martin, Susanne Medical University of Vienna ;
Kühl, Joern S. (Universitätsklinikum Leipzig) ;
Varotto, Stefania (University Hospital of Padova (Pàdua, Itàlia)) ;
Paillard, Catherine (Hôpital Hautepierre) ;
Guilmatre, Audrey (Hôpital Armand Trousseau (París, França)) ;
Sastre, Ana (Hospital Universitario La Paz (Madrid)) ;
Abecasis, Manuel (Instute Portugues Oncologia Lisboa) ;
Garwer, Birgit (University Hospital Eppendorf) ;
Sedlacek, Petr (University Hospital Motol) ;
Boelens, Jaap Jan (Memorial Sloan Kettering Cancer Center) ;
Beohou, Eric (European Society for Blood and Marrow Transplantation Pediatric Disease Working Party) ;
Bader, Peter (University Hospital of Frankfurt (Alemanya)) ;
Universitat Autònoma de Barcelona
We report data obtained from a retrospective multicenter pediatric survey on behalf of the European Society for Blood and Marrow Transplantation (EBMT). Information on solid organ transplantation (SOT) performed in pediatric recipients of either autologous or allogeneic hematopoietic stem cell transplantation (HSCT) between 1984 and 2016 was collected in 20 pediatric EBMT Centers (25. [...]
2019 - 10.1111/ajt.15240
American Journal of Transplantation, Vol. 19 Núm. 6 (june 2019) , p. 1798-1805
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11 p, 529.4 KB |
Nivolumab and sunitinib combination in advanced soft tissue sarcomas : A multicenter, single-arm, phase Ib/II trial
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Martin-Broto, J. (Universidad de Sevilla) ;
Hindi, Nadia (Universidad de Sevilla) ;
Grignani, G. (Candiolo Cancer Institute) ;
Martinez-Trufero, J. (Hospital Universitario Miguel Servet (Saragossa)) ;
Redondo, A. (Hospital Universitario La Paz (Madrid)) ;
Valverde, Claudia (Vall d'Hebron Institut d'Oncologia) ;
Stacchiotti, S. (Istituto Nazionale Tumori) ;
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
D'Ambrosio, L. (Candiolo Cancer Institute) ;
Gutierrez, A. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Perez-Vega, H. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Encinas-Tobajas, V. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
De Álava, Enrique (Universidad de Sevilla) ;
Collini, Paola (Istituto Nazionale Tumori) ;
Peña-Chilet, M. (Hospital Virgen Del Rocio) ;
Dopazo, J. (Hospital Virgen Del Rocío) ;
Carrasco-Garcia, I. (Universidad de Sevilla) ;
Lopez-Alvarez, M. (Universidad de Sevilla) ;
Moura, D.S. (Universidad de Sevilla) ;
Lopez-Martin, Jose A (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Universitat Autònoma de Barcelona
Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity of PD-1 inhibitors. A potential strategy to convert a cold into an inflamed microenvironment lies on a combination therapy. [...]
2020 - 10.1136/jitc-2020-001561
Journal for immunotherapy of cancer, Vol. 8 Núm. 2 (17 2020) , p. e001561
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12 p, 1.3 MB |
An expert patient program to improve the empowerment and quality of life of people with multiple sclerosis : protocol for a multicenter pre-post intervention study
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Robles-Sanchez, Miguel Angel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Amil-Bujan, Paloma (Expert Patient Program Catalonia, Generalitat de Catalunya) ;
Bosch-Farré, Cristina (Universitat de Girona) ;
Coll-Martínez, Clàudia (Hospital de Santa Caterina (Salt, Girona)) ;
Arévalo, María Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Anglada, Elisenda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Menéndez, Rebeca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramió-Torrentà, Lluís (Universitat de Girona) ;
Bertran-Noguer, Carme (Universitat de Girona) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Multiple sclerosis (MS) causes a progressive disability, which substantially impacts the quality of life (QoL). Health interventions that meet the needs and demands of people with MS are essential to minimize QoL impairment. [...]
2023 - 10.3389/fneur.2023.1172640
Frontiers in neurology, Vol. 14 (may 2023)
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9 p, 938.4 KB |
Conducting clinical trials in persons with Down syndrome : summary from the NIH INCLUDE Down syndrome clinical trials readiness working group
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Baumer, Nicole (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Becker, Mara L. (Duke University School of Medicine) ;
Capone, George (The Johns Hopkins School of Medicine) ;
Egan, Kathleen (Parent/Advocate, Virginia, USA) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Handen, Benjamin L. (University of Pittsburgh) ;
Head, Elizabeth (University of California) ;
Hendrix, James E. (LuMind IDSC Foundation, Burlington, USA) ;
Litovsky, Ruth Y. (University of Wisconsin) ;
Strydom, Andre (King's College London) ;
Tapia, Ignacio E. (University of Pennsylvania) ;
Rafii, Michael S. (University of Southern California) ;
Universitat Autònoma de Barcelona
The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in clinical trials involving individuals with Down syndrome (DS). [...]
2022 - 10.1186/s11689-022-09435-z
Journal of Neurodevelopmental Disorders, Vol. 14 (march 2022)
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9 p, 928.6 KB |
Changes in humoral immune response after SARS-CoV-2 infection in liver transplant recipients compared to immunocompetent patients
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Caballero-Marcos, Aránzazu (Hospital General Universitario Gregorio Marañón) ;
Salcedo, Magdalena (Hospital General Universitario Gregorio Marañón) ;
Alonso-Fernández, Roberto (Hospital General Universitario Gregorio Marañón) ;
Rodríguez-Perálvarez, Manuel (Instituto Maimónides de Investigación Biomédica de Córdoba) ;
Olmedo, María (Hospital General Universitario Gregorio Marañón) ;
Graus Morales, Javier (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Cuervas-Mons, Valentín (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Cachero, Alba (Institut d'Investigació Biomèdica de Bellvitge) ;
Loinaz, Carmelo (Hospital Universitario 12 de Octubre (Madrid)) ;
Iñarrairaegui, Mercedes (Clínica Universidad de Navarra) ;
Castells, Lluís (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pascual, Sonia (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Vinaixa-Aunés, Carmen (Hospital Universitari i Politècnic La Fe (València)) ;
González-Grande, Rocío (Hospital Regional Universitario de Málaga) ;
Otero, Alejandra (Complejo Hospitalario Universitario de A Coruña) ;
Tomé, Santiago (Hospital Universitario de Santiago) ;
Tejedor-Tejada, Javier (Hospital Universitario Río Hortega (Valladolid)) ;
Álamo-Martínez, José María (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
González-Diéguez, Luisa (Hospital Universitario Central de Asturias) ;
Nogueras-Lopez, Flor (Hospital Universitario Virgen de las Nieves (Granada)) ;
Blanco-Fernández, Gerardo (Complejo Hospitalario Universitario de Badajoz) ;
Muñoz-Bartolo, Gema (Hospital Universitario La Paz (Madrid)) ;
Bustamante, Francisco Javier (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Fábrega, Emilio (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ;
Romero-Cristóbal, Mario (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Martin-Mateos, Rosa (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Del Rio-Izquierdo, Julia (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Arias-Milla, Ana (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Calatayud, Laura (Institut d'Investigació Biomèdica de Bellvitge) ;
Marcacuzco-Quinto, Alberto A. (Hospital Universitario 12 de Octubre (Madrid)) ;
Fernández-Alonso, Víctor (Hospital General Universitario Gregorio Marañón) ;
Gómez Gavara, Concepción (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Colmenero, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Muñoz, Patricia (Hospital General Universitario Gregorio Marañón) ;
Pons, José A. (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
The protective capacity and duration of humoral immunity after SARS-CoV-2 infection are not yet understood in solid organ transplant recipients. A prospective multicenter study was performed to evaluate the persistence of anti-nucleocapsid IgG antibodies in liver transplant recipients 6 months after coronavirus disease 2019 (COVID-19) resolution. [...]
2021 - 10.1111/ajt.16599
American Journal of Transplantation, Vol. 21 Num. 8 (Aug. 2021)
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18 p, 1.6 MB |
Understanding How to Improve the Use of Clinical Coordination Mechanisms between Primary and Secondary Care Doctors : Clues from Catalonia
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Esteve-Matalí, Laura (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Vargas, Ingrid (Consorci de Salut i Social de Catalunya) ;
Amigo, Franco (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Plaja, Pere (Fundació Salut Empordà) ;
Cots Reguant, Francesc (Parc de Salut MAR de Barcelona) ;
Mayer, Erick F. (Serveis de Salut Integrats Baix Empordà, 17230 Palamós, Spain) ;
Pérez-Castejón, Joan-Manuel (Badalona Serveis Assistencials) ;
Vázquez, María-Luisa (Consorci de Salut i Social de Catalunya)
Clinical coordination between primary (PC) and secondary care (SC) is a challenge for health systems, and clinical coordination mechanisms (CCM) play an important role in the interface between care levels. [...]
2021 - 10.3390/ijerph18063224
International journal of environmental research and public health, Vol. 18 (march 2021)
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12 p, 1.2 MB |
Colorectal cancer health services research study protocol : the CCR-CARESS observational prospective cohort project
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Quintana López, José María (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC)) ;
Gonzalez, Nerea (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC)) ;
Anton-Ladislao, Ane (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC)) ;
Redondo, Maximino (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC)) ;
Baré i Mañas, Marisa (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Fernandez de Larrea, Nerea (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC)) ;
Briones, Eduardo (Salud Publica (Sevilla)) ;
Escobar, Antonio (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC)) ;
Sarasqueta, Cristina (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC)) ;
Garcia-Gutierrez, Susana (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC)) ;
Aguirre, Urko (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC)) ;
Universitat Autònoma de Barcelona
Colorectal cancers are one of the most common forms of malignancy worldwide. But two significant areas of research less studied deserve attention: health services use and development of patient stratification risk tools for these patients. [...]
2016 - 10.1186/s12885-016-2475-y
BMC Cancer, Vol. 16 (july 2016)
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14 p, 981.8 KB |
Examining database persistence of ISO/EN 13606 standardized electronic health record extracts : relational vs. NoSQL approaches
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Sánchez-de-Madariaga, Ricardo (Instituto de Salud Carlos III) ;
Muñoz, Adolfo (Instituto de Salud Carlos III) ;
Lozano-Rubí, Raimundo (Universitat Autònoma de Barcelona. Departament de Ciències de la Computació) ;
Serrano-Balazote, Pablo (Hospital Universitario 12 de Octubre (Madrid)) ;
Castro, Antonio L. (Instituto de Salud Carlos III) ;
Moreno, Oscar (Instituto de Salud Carlos III) ;
Pascual, Mario (Instituto de Salud Carlos III)
The objective of this research is to compare the relational and non-relational (NoSQL) database systems approaches in order to store, recover, query and persist standardized medical information in the form of ISO/EN 13606 normalized Electronic Health Record XML extracts, both in isolation and concurrently. [...]
2017 - 10.1186/s12911-017-0515-4
BMC Medical Informatics and Decision Making, Vol. 17 (August 2017) , art. 123
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