Resultats globals: 53 registres trobats en 0.02 segons.
Articles, 50 registres trobats
Documents de recerca, 3 registres trobats
Articles 50 registres trobats  1 - 10següentfinal  anar al registre:
1.
52 p, 1.9 MB Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase / Crespo, Isidro (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Giménez-Dejoz, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Porté, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cousido-Siah, Alexandra (Institut de Génétique et de Biologie Moléculaire et Cellulaire, France) ; Mitschler, André (Institut de Génétique et de Biologie Moléculaire et Cellulaire, France) ; Podjarny, Alberto (Institut de Génétique et de Biologie Moléculaire et Cellulaire, France) ; Pratsinis, Harris (Institute of Biosciences and Applications, National Centre of Scientific Research "Demokritos", Athens, Greece) ; Kletsas, Dimitris (Institute of Biosciences and Applications, National Centre of Scientific Research "Demokritos", Athens, Greece) ; Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ruiz, Francesc Xavier (Institut de Génétique et de Biologie Moléculaire et Cellulaire, France) ; Metwally, Kamel (Zagazig University, Egypt) ; Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Human aldose reductase (AKR1B1, AR) is a key enzyme of the polyol pathway, catalyzing the reduction of glucose to sorbitol at high glucose concentrations, as those found in diabetic condition. Indeed, AKR1B1 overexpression is related to diabetes secondary complications and, in some cases, with cancer. [...]
2018 - 10.1016/j.ejmech.2018.04.015
European Journal of Medicinal Chemistry, Vol. 152 (2018) , p. 160-174  
2.
19 p, 5.7 MB The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases / Luang, Sukanya (University of Adelaide) ; Fernández-Luengo Flores, Xavier (Universitat Autònoma de Barcelona. Departament de Química) ; Nin-Hill, Alba (Universitat de Barcelona. Departament de Química Inorgànica i Orgànica) ; Streltsov, Victor A. (University of Melbourne. The Florey Institute) ; Schwerdt, Julian G. (University of Adelaide) ; Alonso-Gil, Santiago (Universitat de Barcelona. Departament de Química Inorgànica i Orgànica) ; Ketudat Cairns, James R. (Suranaree University of Technology. School of Chemistry) ; Pradeau, Stéphanie (Université Grenoble Alpes. Centre de Recherches sur les Macromolécules Végétales) ; Fort, Sebastien (Université Grenoble Alpes. Centre de Recherches sur les Macromolécules Végétales) ; Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ; Masgrau, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rovira, Carme (Institució Catalana de Recerca i Estudis Avançats) ; Hrmova, Maria (Huaiyin Normal University)
In the barley β-D-glucan glucohydrolase, a glycoside hydrolase family 3 (GH3) enzyme, the Trp286/Trp434 clamp ensures β-D-glucosides binding, which is fundamental for substrate hydrolysis during plant growth and development. [...]
2022 - 10.1038/s41467-022-33180-5
Nature communications, Vol. 13 (September 2022) , art. 5577  
3.
12 p, 3.2 MB Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3 / Castellví Toledo, Albert (ALBA Laboratori de Llum de Sincrotró) ; Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Barracco, Vito (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Juanhuix, Judith (ALBA Laboratori de Llum de Sincrotró) ; Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Human aldehyde dehydrogenase (ALDH) participates in the oxidative stress response and retinoid metabolism, being involved in several diseases, including cancer, diabetes and obesity. The ALDH1A3 isoform has recently elicited wide interest because of its potential use as a cancer stem cell biomarker and drug target. [...]
2022 - 10.1038/s42003-022-03311-1
Communications Biology, Vol. 5 (April 2022) , art. 354  
4.
10 p, 3.5 MB Structure and mechanism of the Nap adhesion complex from the human pathogen Mycoplasma genitalium / Aparicio Alarcón, David (Institut de Biologia Molecular de Barcelona) ; Scheffer, Margot P. (Buchmann Institute for Molecular Life Sciences) ; Marcos Silva, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Vizarraga, David (Institut de Biologia Molecular de Barcelona) ; Sprankel, Lasse (Buchmann Institute for Molecular Life Sciences) ; Ratera, Mercè (Institut de Biologia Molecular de Barcelona) ; Weber, Miriam S. (Buchmann Institute for Molecular Life Sciences) ; Seybert, Anja (Buchmann Institute for Molecular Life Sciences) ; Torres Puig, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gonzalez-Gonzalez, Luis 1987- (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Reitz, Julian (Buchmann Institute for Molecular Life Sciences) ; Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Quijada Pich, Oscar (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Fita, Ignacio (Institut de Biologia Molecular de Barcelona) ; Frangakis, Achilleas S. (Buchmann Institute for Molecular Life Sciences)
Mycoplasma genitalium is a human pathogen adhering to host target epithelial cells and causing urethritis, cervicitis and pelvic inflammatory disease. Essential for infectivity is a transmembrane adhesion complex called Nap comprising proteins P110 and P140. [...]
2020 - 10.1038/s41467-020-16511-2
Nature communications, Vol. 11 (June 2020) , art. 2877  
5.
16 p, 3.9 MB Plasticity in the Oxidative Folding Pathway of the High Affinity Nerita Versicolor Carboxypeptidase Inhibitor (NvCI) / Esperante, Sebastián (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bronsoms, Sílvia (Universitat Autònoma de Barcelona. Servei de Proteòmica i Biologia Estructural) ; Covaleda Cortés, Giovanni (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Trejo, Sebastián A. (Universitat Autònoma de Barcelona. Servei de Proteòmica i Biologia Estructural) ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Nerita Versicolor carboxypeptidase inhibitor (NvCI) is the strongest inhibitor reported so far for the M14A subfamily of carboxypeptidases. It comprises 53 residues and a protein fold composed of a two-stranded antiparallel β sheet connected by three loops and stabilized by three disulfide bridges. [...]
2017 - 10.1038/s41598-017-05657-7
Scientific reports, Vol. 7 (2017) , art. 5457  
6.
13 p, 2.3 MB A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25 / Liu, Bing (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sureda-Gómez, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Zhen, Yang (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Amador, Virginia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
USP25 deubiquitinating enzyme is a key member of the ubiquitin system, which acts as a positive regulator of the Wnt/β-catenin signaling by promoting the deubiquitination and stabilization of tankyrases. [...]
2018 - 10.1038/s41467-018-07510-5
Nature communications, Vol. 9 (2018) , art. 4973  
7.
10 p, 6.7 MB Structural analysis and evolution of specificity of the SUMO UFD E1-E2 interactions / Liu, Bing (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lois, L. Maria (Centre de Recerca en Agrigenòmica) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukaryotes and is essential for the regulation of processes such as DNA damage repair, transcription, DNA replication and mitosis. [...]
2017 - 10.1038/srep41998
Scientific reports, Vol. 7 (February 2017) , art. 41998  
8.
15 p, 3.9 MB Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregationres / Sant'Anna, Ricardo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Almedia, Maria Rosario (Instituto de Investigação e Inovação em Saúde da Universidade do Porto) ; Varejao, Nathalia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gallego Alonso, Pablo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Esperante, Sebastián (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferreira, Priscilla (Instituto de Bioquímica Médica Leopoldo de Meis) ; Pereira-Henriques, Alda (Instituto de Investigação e Inovação em Saúde da Universidade do Porto) ; Palhano, Fernando L. (Instituto de Bioquímica Médica Leopoldo de Meis) ; De Carvalho, Mamede (Department Neurosciences. Hospital de Santa Maria. CHLN) ; Foguel, Debora (Instituto de Bioquímica Médica Leopoldo de Meis) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Saraiva, Maria Joao (Instituto de Investigação e Inovação em Saúde da Universidade do Porto) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
More than a hundred different Transthyretin (TTR) mutations are associated with fatal systemic amyloidoses. They destabilize the protein tetrameric structure and promote the extracellular deposition of TTR as pathological amyloid fibrils. [...]
2017 - 10.1038/srep44709
Scientific reports, Vol. 7 (2017) , art. 44709  
9.
12 p, 1.7 MB Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization / Haq, Tamanna (University of Leicester. Department of Biochemistry) ; Richards, Mark W. (University of Leicester. Department of Biochemistry) ; Burgess, Selena G. (University of Leicester. Department of Biochemistry) ; Gallego Alonso, Pablo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yeoh, Sharon (University of Leicester. Department of Biochemistry) ; O'Regan, Laura (University of Leicester. Department of Biochemistry) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Roig, Joan (Institut de Recerca Biomèdica de Lleida) ; Fry, Andrew M. (University of Leicester. Department of Biochemistry) ; Bayliss, Richard (Cancer Research UK Leicester Centre)
Mitotic spindle assembly requires the regulated activities of protein kinases such as Nek7 and Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated by the Nek9 non-catalytic C-terminal domain (CTD). [...]
2015 - 10.1038/ncomms9771
Nature communications, Vol. 6 (2015) , art. 8771  
10.
13 p, 2.9 MB Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation / Castellví Toledo, Albert (ALBA Laboratori de Llum de Sincrotró) ; Crespo, Isidro (ALBA Laboratori de Llum de Sincrotró) ; Crosas, Eva (ALBA Laboratori de Llum de Sincrotró) ; Cámara-Artigas, Ana (Universidad de Almería) ; Gavira, José A. (Universidad de Granada) ; Aranda, Miguel A. G. (ALBA Laboratori de Llum de Sincrotró) ; Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Juanhuix, Judith (ALBA Laboratori de Llum de Sincrotró)
Human aldose reductase (hAR, AKR1B1) has been explored as drug target since the 1980s for its implication in diabetic complications. An activated form of hAR was found in cells from diabetic patients, showing a reduced sensitivity to inhibitors in clinical trials, which may prevent its pharmacological use. [...]
2019 - 10.1038/s41598-019-39722-0
Scientific reports, Vol. 9 (February 2019) , art. 3177  

Articles : 50 registres trobats   1 - 10següentfinal  anar al registre:
Documents de recerca 3 registres trobats  
1.
194 p, 9.6 MB Structural characterization of a mitochondrial dna maintenance protein of biomedical interest / Tarrés Solé, Aleix ; Solà Vilarrubias, Maria, dir. ; Villegas Hernández, Sandra, dir.
En aquest treball de tesi presentem la caracterització estructural de la proteïna de 'Candida albicans' ('C. albicans') Gcf1p. Gcf1p és una proteïna d'unió a l'ADN, que localitza al mitocondri de 'C. [...]
En este trabajo de tesis se presenta la caracterización estructural de la proteína de 'Candida albicans' ('C. albicans') Gcf1p. Gcf1p es una proteína de unión al ADN, que transloca a la mitocondria de 'C. [...]
This thesis work is centred in the structural characterisation of Candida albicans (C. albicans) Gcf1p. Gcf1p is a DNA-binding protein located in C. albicans mitochondria that is essential for mitochondrial DNA (mtDNA) maintenance as well as for the viability of such organism. [...]

2020  
2.
153 p, 2.0 MB Structural studies on protein-protein interactions: Analysis of the regulation of the DYNLL/LC8 binding to Nek9 and characterization of the enzymes composing the arginine deiminase pathway in mycoplasma penetrans / Gallego Alonso, Pablo ; Reverter i Cendrós, David, dir. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Las interacciones proteína-proteína (PPIs, por sus siglas en inglés) son contactos físicos intencionados que se dan entre dos o más proteínas. Estas interacciones forman la red de interacciones de proteínas y forman el núcleo del sistema interatómica de toda célula viva. [...]
Protein-Protein Interactions (PPIs) are intentional physical contacts established between two or more proteins. These interactions form the large protein interaction network and are the core of the entire interatomic system of any living cell. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
3.
1 p, 1.2 MB Insights of techniques applied into protein engineering and proteomics / Fernandez, Marc ; Vendrell i Roca, Josep, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2013
Grau en Bioquímica [814]  

Us interessa rebre alertes sobre nous resultats d'aquesta cerca?
Definiu una alerta personal via correu electrònic o subscribiu-vos al canal RSS.