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1.
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14 p, 7.3 MB |
Alcohol-free synthesis, biological assessment, in vivo toxicological evaluation, and in silico analysis of novel silane quaternary ammonium compounds differing in structure and chain length as promising disinfectants
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Tagorti, Ghada (Akdeniz University. Department of Biology) ;
Yalçın, Burçin (Akdeniz University. Department of Biology) ;
Güneş, Merve (Akdeniz University. Department of Biology) ;
Burgazlı, Ayşen Yağmur (Akdeniz University. Department of Biology) ;
Kuruca, Tuğçe (Akdeniz University. Department of Chemistry) ;
Cihanoğlu, Neslihan (Akdeniz University. Department of Chemistry) ;
Akarsu, Esin (Akdeniz University. Department of Chemistry) ;
Kaya, Nuray (Akdeniz University. Department of Biology) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Kaya, Bülent (Akdeniz University. Department of Biology)
Quaternary ammonium compounds (QACs) are commonly used as disinfectants for industrial, medical, and residential applications. However, adverse health outcomes have been reported. Therefore, biocompatible disinfectants must be developed to reduce these adverse effects. [...]
2024 -  10.1016/j.jhazmat.2024.133470
Journal of hazardous materials, Vol. 466 (March 2024) , art. 133470
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2.
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12 p, 2.5 MB |
Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice
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Galindo Campos, Miguel A. (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Lutfi, Nura (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Bonnin, Sarah (Centre de Regulació Genòmica) ;
Martínez Cáceres, Carlos (Instituto Murciano de Investigación Biosanitaria-Laboratorio de Investigación Biosanitaria-Arrixaca) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Hernández, Violeta (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Martín Caballero, Juan (Instituto Cajal. Consejo Superior de Investigaciones Científicas (CSIC)) ;
Ampurdanés, Coral (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Gimeno, Ramón (Laboratory of Immunology. Department of Pathology) ;
Colomo, Lluís (Hospital del Mar (Barcelona, Catalunya)) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guilbaud, Guillaume (Division of Protein and Nucleic Acid Chemistry. Medical Research Council Laboratory of Molecular Biology) ;
Dantzer, Françoise (Biotechnology and Cell Signaling. Unité Mixte de Recherche (UMR) 7242 Centre National de la Recherche Scientifique. Laboratory of Excellence Medalis. École Supérieure de Biotechnologie de Strasbourg. Strasbourg University) ;
Navarro, Pilar (Hospital del Mar Medical Research Institute. Unidad Asociada IIBB-CSIC) ;
Murga, Matilde (Genomic Instability Group. Spanish National Cancer Research Centre) ;
Fernández Capetillo, Oscar (Science for Life Laboratory. Department of Medical Biochemistry and Biophysics. Karolinska Institutet) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sale, Julian E. (Division of Protein and Nucleic Acid Chemistry. Medical Research Council Laboratory of Molecular Biology) ;
Yélamos, José (Laboratory of Immunology. Department of Pathology)
Dysregulation of the c-Myc oncogene occurs in a wide variety of hematologic malignancies, and its overexpression has been linked with aggressive tumor progression. Here, we show that poly (ADP-ribose) polymerase 1 (PARP-1) and PARP-2 exert opposing influences on progression of c-Myc-driven B-cell lymphoma. [...]
2022 - 10.1182/blood.2021012805
Blood, Vol. 139 Núm. 2 (13 2022) , p. 228-239
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3.
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4.
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17 p, 19.2 MB |
Alterations in p53, Microsatellite Stability and Lack of MUC5AC Expression as Molecular Features of Colorectal Carcinoma Associated with Inflammatory Bowel Disease
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Gené, Míriam (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Cuatrecasas, Miriam (Hospital Clínic i Provincial de Barcelona) ;
Amat, Irene (Complejo Hospitalario de Navarra) ;
Veiga, Jesús Alberto (Complejo Hospitalario Universitario de Ferrol) ;
Fernández Aceñero, María Jesús (Hospital Clínico San Carlos (Madrid)) ;
Fusté Chimisana, Victòria (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Tarragona, Jordi (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Jurado, Ismael (Consorci Sanitari de Terrassa) ;
Fernández-Victoria, Rebeca (Hospital Álvaro Cunqueiro (Vigo)) ;
Martínez Ciarpaglini, Carolina (Hospital Clínic Universitari (València)) ;
Alenda González, Cristina (Hospital General Universitario Dr. Balmis) ;
Zac, Carlos (Hospital Universitari i Politècnic La Fe (València)) ;
Ortega de la Obra, Pilar (Hospital General de Segovia) ;
Fernández-Figueras, María Teresa (Universitat Internacional de Catalunya) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Musulén, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Colitis-associated colorectal carcinoma (CAC) occurs in inflammatory bowel disease (IBD) because of the "chronic inflammation-dysplasia-cancer" carcinogenesis pathway characterized by p53 alterations in the early stages. [...]
2023 - 10.3390/ijms24108655
International journal of molecular sciences, Vol. 24 (may 2023)
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5.
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20 p, 1.7 MB |
Seminal Microbiota of Idiopathic Infertile Patients and Its Relationship With Sperm DNA Integrity
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Garcia Segura, Sergio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Del Rey Azpiri, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Closa, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Martinez, Iris (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hobeich, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castel, Ana Belén (Instituto de Fertilidad) ;
Vidal, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Benet i Català, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ribas-Maynou, Jordi (Universitat de Girona. Departament de Biologia Cel·lular) ;
Oliver Bonet, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The development of new biomarkers for human male infertility is crucial to improve the diagnosis and the prognosis of this disease. Recently, seminal microbiota was shown to be related to sperm quality parameters, suggesting an effect in human fertility and postulating it as a biomarker candidate. [...]
2022 - 10.3389/fcell.2022.937157
Frontiers in Cell and Developmental Biology, Vol. 10 (June 2022) , art. 937157
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6.
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12 p, 12.0 MB |
Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response
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Cristalli, Camilla (IRCCS Istituto Ortopedico Rizzoli) ;
Manara, Maria Cristina (IRCCS Istituto Ortopedico Rizzoli) ;
Valente, Sergio (Sapienza University of Rome) ;
Pellegrini, Evelin (IRCCS Istituto Ortopedico Rizzoli) ;
Bavelloni, Alberto (IRCCS Istituto Ortopedico Rizzoli) ;
De Feo, Alessandra (IRCCS Istituto Ortopedico Rizzoli) ;
Blalock, William (Istituto di Genetica Molecolare-Luigi Luca Cavalli Sforza) ;
Di Bello, Elisabetta (Sapienza University of Rome) ;
Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tirado, Oscar M. (Institut d'Investigació Biomèdica de Bellvitge) ;
Mai, Antonello (Sapienza University of Rome) ;
Scotlandi, Katia (IRCCS Istituto Ortopedico Rizzoli)
DNA methylation is an important component of the epigenetic machinery that regulates the malignancy of Ewing sarcoma (EWS), the second most common primary bone tumor in children and adolescents. Coordination of DNA methylation and DNA replication is critical for maintaining epigenetic programming and the DNMT1 enzyme has been demonstrated to have an important role in both maintaining the epigenome and controlling cell cycle. [...]
2022 - 10.3389/fendo.2022.876602
Frontiers in Endocrinology, Vol. 13 (31 2022) , p. 876602
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25 p, 6.2 MB |
Poly(Adp-ribose) binding and macroh2a mediate recruitment and functions of kdm5a at dna lesions
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Kumbhar, Ramhari (University of Texas at Austin) ;
Sanchez, Anthony (University of Texas at Austin) ;
Perren, Jullian (University of Texas at Austin) ;
Gong, Fade (Baylor College of Medicine) ;
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Medina, Frank (University of Texas at Austin) ;
Devanathan, Sravan K. (University of Texas at Austin) ;
Xhemalce, Blerta (University of Texas at Austin) ;
Matouschek, Andreas (University of Texas at Austin) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Buck-Koehntop, Bethany A. (University of Utah) ;
Miller, Kyle M. (University of Texas at Austin) ;
Universitat Autònoma de Barcelona
The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. [...]
2021 - 10.1083/jcb.202006149
The journal of cell biology, Vol. 220 Núm. 7 (2021) , p. e202006149
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8.
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16 p, 4.3 MB |
Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells
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González-Bermúdez, Lourdes (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Genescà, Anna (Institut Català d'Oncologia) ;
Terradas, Mariona (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martín Flix, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Increased frequency of DNA double strand breaks (DSBs) with aging suggests an age-associated decline in DSB repair efficiency, which is also influenced by the epigenetic landscape. H4 acetylation at lysine 16 (H4K16Ac) has been related to DSB repair since deacetylation of this mark is required for efficient 53BP1 recruitment to DSBs. [...]
2022 - 10.1007/s10522-022-09979-6
Biogerontology, Vol. 23, Issue 4 (August 2022) , p. 499-514
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9.
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15 p, 3.5 MB |
Nanoplastics and arsenic co-exposures exacerbate oncogenic biomarkers under an in vitro long-term exposure scenario
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Barguilla, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Domenech, Josefa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Rubio Lorente, Laura (Universidad Católica Madre y Maestra. Departamento de Ciencias Naturales y Exactas) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The increasing accumulation of plastic waste and the widespread presence of its derivatives, micro- and nanoplastics (MNPLs), call for an urgent evaluation of their potential health risks. In the environment, MNPLs coexist with other known hazardous contaminants and, thus, an interesting question arises as to whether MNPLs can act as carriers of such pollutants, modulating their uptake and their harmful effects. [...]
2022 - 10.3390/ijms23062958
International journal of molecular sciences, Vol. 23, issue 6 (March 2022) ,art. 2958
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10.
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36 p, 800.8 KB |
Establishment and validation of surface model for biodosimetry based on γ-H2AX foci detection
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López Vásquez, Juan Sebastián (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Pujol Canadell, Mònica (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Puig, Pedro (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Ribas, Montserrat (Institut d'Investigació Biomèdica Sant Pau) ;
Carrasco de Fez, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Armengol Rosell, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Barquinero, Joan Francesc (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Introduction: In the event of a radiation accident detecting γ-H2AX foci is being accepted as fast method for triage and dose assessment. However, due to their disappearance kinetics, published calibrations have been constructed at specific post-irradiation times. [...]
2022 - 10.1080/09553002.2022.1998706
International Journal of Radiation Biology, Vol. 98, Issue 1 (2022) , p. 1-10
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