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Resultats globals: 7 registres trobats en 0.04 segons.
Articles, 7 registres trobats
Articles 7 registres trobats  
1.
14 p, 7.3 MB Distal Mutations Shape Substrate-Binding Sites during Evolution of a Metallo-Oxidase into a Laccase / Brissos, Vânia (Universidade Nova de Lisboa) ; Borges, Patrícia T. (Universidade Nova de Lisboa) ; Núñez-Franco, Reyes (Zymvol Biomodeling) ; Lucas, Maria Fátima (Zymvol Biomodeling) ; Frazão, Carlos (Universidade Nova de Lisboa) ; Monza, Emanuele (Zymvol Biomodeling) ; Masgrau, Laura (Universitat Autònoma de Barcelona. Departament de Química) ; Cordeiro, Tiago N. (Universidade Nova de Lisboa) ; Martins, Lígia O. (Universidade Nova de Lisboa)
Laccases are in increasing demand as innovative solutions in the biorefinery fields. Here, we combine mutagenesis with structural, kinetic, and in silico analyses to characterize the molecular features that cause the evolution of a hyperthermostable metallo-oxidase from the multicopper oxidase family into a laccase (k 273 s -1 for a bulky aromatic substrate). [...]
2022 - 10.1021/acscatal.2c00336
ACS catalysis, Vol. 12, Issue 9 (April 2022) , p. 5022-5035  
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2.
14 p, 879.1 KB Parent-offspring genotyped trios unravelling genomic regions with gametic and genotypic epistatic transmission bias on the cattle genome / Id-Lahoucine, Samir (University of Guelph. Department of Animal Biosciences) ; Casellas Vidal, Joaquim (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Miglior, Filippo (University of Guelph. Department of Animal Biosciences) ; Schenkel, Flavio S. (University of Guelph. Department of Animal Biosciences) ; Cánovas, Angela (University of Guelph. Department of Animal Biosciences)
Several biological mechanisms affecting the sperm and ova fertility and viability at developmental stages of the reproductive cycle resulted in observable transmission ratio distortion (i. e. , deviation from Mendelian expectations). [...]
2023 - 10.3389/fgene.2023.1132796
Frontiers in genetics, Vol. 14 (april 2023)  
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3.
14 p, 1.7 MB When pitch adds to volume : coregulation of transcript diversity predicts gene function / Cáceres, Alejandro (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; González, Juan Ramón (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
Background: Genes corregulate their overall transcript volumes to perform their physiological functions. However, it is unknown if they additionally coregulate their transcript diversities. We studied the reliability, consistency and functional associations of co-splicing correlations of genes of interest, across two independent studies, multiple tissues and two statistical methods. [...]
2018 - 10.1186/s12864-018-5263-z
BMC genomics, Vol. 19 (December 2018) , art. 926  
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4.
14 p, 2.0 MB Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation / Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bywater, M. J. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Sanij, E. (Department of Pathology. University of Melbourne) ; Cameron, D. P. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ; Schierding, W. (Liggins Institute. The University of Auckland) ; Brajanovski, N. (Cancer Research Division. Peter MacCallum Cancer Centre) ; Son, J. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ; Sornkom, J. (Sir Peter MacCallum Department of Oncology. University of Melbourne) ; Hein, N. (ACRF Department of Cancer Biology and Therapeutics. John Curtin School of Medical Research. Australian National University) ; Evers, M. (ACRF Department of Cancer Biology and Therapeutics. John Curtin School of Medical Research. Australian National University) ; Pearson, R. B. (Department of Biochemistry and Molecular Biology. University of Melbourne) ; McArthur, G. A. (St Vincent's Hospital (Sydney)) ; Ganley, A. R. D. (School of Biological Sciences. The University of Auckland) ; O'Sullivan, J. M. (Liggins Institute. The University of Auckland) ; Hannan, R. D. (School of Biomedical Sciences. University of Queensland) ; Poortinga, G. (St Vincent's Hospital (Sydney)) ; Universitat Autònoma de Barcelona
The three-dimensional organization of the genome contributes to its maintenance and regulation. While chromosomal regions associate with nucleolar ribosomal RNA genes (rDNA), the biological significance of rDNA-genome interactions and whether they are dynamically regulated during disease remain unclear. [...]
2019 - 10.1038/s42003-019-0284-y
Communications Biology, Vol. 2 Núm. 1 (january 2019) , p. 39  
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5.
14 p, 1.9 MB Exploring deep learning for complex trait genomic prediction in polyploid outcrossing species / Zingaretti, Laura M. (Centre de Recerca en Agrigenòmica) ; Gezan, Salvador Alejandro (University of Florida. School of Forest Resources and Conservation (USA)) ; Ferrão, Luis Felipe V. (University of Florida. Horticultural Sciences Department (USA)) ; Osorio, Luis F. (University of Florida. IFAS Gulf Coast Research and Education Center (USA)) ; Monfort, Amparo (Centre de Recerca en Agrigenòmica) ; Muñoz, Patricio R. (University of Florida. Horticultural Sciences Department (USA)) ; Whitaker, Vance M. (University of Florida. IFAS Gulf Coast Research and Education Center (USA)) ; Perez-Enciso, Miguel (Centre de Recerca en Agrigenòmica)
Genomic prediction (GP) is the procedure whereby the genetic merits of untested candidates are predicted using genome wide marker information. Although numerous examples of GP exist in plants and animals, applications to polyploid organisms are still scarce, partly due to limited genome resources and the complexity of this system. [...]
2020 - 10.3389/fpls.2020.00025
Frontiers in plant science, Vol. 11 (February 2020) , art. 25  
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6.
16 p, 1.3 MB Latitudinal Clines of the Human Vitamin D Receptor and Skin Color Genes / Tiosano, Dov (Technion - Israel Institute of Technology. Rappaport Family Faculty of Medicine) ; Audí, Laura (Hospital Universitari Vall d'Hebron) ; Climer, Sharlee (Department of Computer Science and Engineering, Washington University) ; Zhang, Weixiong (Department of Computer Science and Engineering) ; Templeton, Alan R. (Department of Evolutionary and Environmental Biology, University of Haifa) ; Fernández Cancio, Mónica (Hospital Universitari Vall d'Hebron) ; Gershoni-Baruch, Ruth (Department of Evolutionary and Environmental Biology, University of Haifa) ; Sánchez-Muro, José Miguel (Pediatric Service, Area Basica de Salut (ABS)) ; El Kholy, Mohamed (Department of Pediatrics, Ain Shams University) ; Hochberg, Zèev (Technion - Israel Institute of Technology. Rappaport Family Faculty of Medicine) ; Universitat Autònoma de Barcelona
The well-documented latitudinal clines of genes affecting human skin color presumably arise from the need for protection from intense ultraviolet radiation (UVR) vs. the need to use UVR for vitamin D synthesis. [...]
2016 - 10.1534/g3.115.026773
G3, Vol. 6 (february 2016) , p. 1251-1266  
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7.
9 p, 421.4 KB An Epistatic Interaction between the PAX8 and STK17B Genes in Papillary Thyroid Cancer Susceptibility / Landa, Iñigo (Centro Nacional de Investigaciones Oncológicas) ; Boullosa, Cesar (Centro Nacional de Investigaciones Oncológicas) ; Inglada Pérez, Lucia (Centro Nacional de Investigaciones Oncológicas) ; Sastre Perona, Ana (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Velázquez, Antonia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Mancikova, Veronika (Centro Nacional de Investigaciones Oncológicas) ; Ruiz Llorente, Sergio (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Schiavi, Francesca (Institut d'Oncologia Vèneto. Clínica de Càncer Familiar i Oncoendocrinologia) ; Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Malats, Núria (Centro Nacional de Investigaciones Oncológicas) ; Opocher, Giuseppe (Veneto Institute of Oncology (Pàdua, Itàlia)) ; Diaz Uriarte, Ramón (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Santisteban, Pilar (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Valencia, Alfonso (Centro Nacional de Investigaciones Oncológicas) ; Robledo, Mercedes (Centro Nacional de Investigaciones Oncológicas)
Papillary Thyroid Cancer (PTC) is a heterogeneous and complex disease; susceptibility to PTC is influenced by the joint effects of multiple common, low-penetrance genes, although relatively few have been identified to date. [...]
2013 - 10.1371/journal.pone.0074765
PloS one, Vol. 8 Issue 9 (September 2013) , p. e74765  
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