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22 p, 2.8 MB |
Combining multi-OMICs information to identify key-regulator genes for pleiotropic effect on fertility and production traits in beef cattle
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Fonseca, Pablo Augusto de Souza (Universidade Federal de Minas Gerais. Departamento de Biologia Geral) ;
Id-Lahoucine, Samir (University of Guelph. Department of Animal Biosciences) ;
Reverter, Antonio (CSIRO Agriculture and Food. Queensland Bioscience Precinct) ;
Medrano, Juan F. (University of California-Davis. Department of Animal Science) ;
Fortes, Marina S. (The University of Queensland. School of Chemistry and Molecular Biosciences) ;
Casellas Vidal, Joaquim (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Miglior, Filippo (Canadian Dairy Network) ;
Brito, Luiz (University of Guelph. Department of Animal Biosciences) ;
Carvalho, Maria Raquel S. (Universidade Federal de Minas Gerais. Departamento de Biologia Geral) ;
Schenkel, Flavio S (University of Guelph. Department of Animal Biosciences) ;
Nguyen, Loan T. (The University of Queensland. School of Chemistry and Molecular Biosciences) ;
Porto-Neto, Laercio R. (CSIRO Agriculture and Food. Queensland Bioscience Precinct) ;
Thomas, Milton G. (Colorado State University. Department of Animal Science) ;
Cánovas, Angela (University of Guelph. Department of Animal Biosciences)
The identification of biological processes related to the regulation of complex traits is a difficult task. Commonly, complex traits are regulated through a multitude of genes contributing each to a small part of the total genetic variance. [...]
2018 -  10.1371/journal.pone.0205295
PloS one, Vol. 13 (october 2018)
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21 p, 2.4 MB |
Differential DNA methylation of vocal and facial anatomy genes in modern humans
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Gokhman, David (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel)) ;
Nissim-Rafinia, Malka (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel)) ;
Agranat-Tamir, Lily (The Hebrew University of Jerusalem. Department of Statistics (Israel)) ;
Housman, Genevieve (Arizona State University. Center for Evolution and Medicine (USA)) ;
García Perez, Raquel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Lizano, Esther (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Cheronet, Olivia (University of Vienna. Department of Evolutionary Anthropology (Austria)) ;
Mallick, Swapan (Howard Hughes Medical Institute. Harvard Medical School (USA)) ;
Nieves-Colón, Maria A. (Arizona State University. Center for Evolution and Medicine (USA)) ;
Li, Heng (Broad Institute of MIT and Harvard) ;
Alpaslan-Roodenberg, Songül (Harvard Medical School. Department of Genetics (USA)) ;
Novak, Mario (University College Dublin. Earth Institute and School of Archaeology (Ireland)) ;
Gu, Hongcang (Broad Institute of MIT and Harvard) ;
Osinski, Jason M. (University at Buffalo. Jacobs School of Medicine and Biomedical Sciences. Department of Biochemistry (USA)) ;
Ferrando-Bernal, Manuel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Gelabert, Pere (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Lipende, Iddi (Jane Goodall Institute. Gombe Stream Research Center (Tanzania)) ;
Mjungu, Deus (Jane Goodall Institute. Gombe Stream Research Center (Tanzania)) ;
Kondova, Ivanela (Biomedical Primate Research Centre (Netherlands)) ;
Bontrop, Ronald (Biomedical Primate Research Centre (Netherlands)) ;
Kullmer, Ottmar (Senckenberg Center of Human Evolution and Paleoecology. Department of Palaeoanthropology and Messel Research (Germany)) ;
Weber, Gerhard (University of Vienna. Department of Evolutionary Anthropology (Austria)) ;
Shahar, Tal (Shaare Zedek Medical Center. Department of Neurosurgery (Israel)) ;
Dvir-Ginzberg, Mona (Hebrew University of Jerusalem. Institute of Dental Sciences. Laboratory of Cartilage Biology (Israel)) ;
Faerman, Marina (Hebrew University of Jerusalem. Institute of Dental Sciences. Laboratory of Bioanthropology and Ancient DNA (Israel)) ;
Quillen, Ellen E. (Texas Biomedical Research Institute. Department of Genetics (USA)) ;
Meissner, Alexander (Harvard University. Department of Stem Cell and Regenerative Biology (USA)) ;
Lahav, Yonatan (The Hebrew University Medical School (Israel)) ;
Kandel, Leonid (Hadassah - Hebrew University Medical Center. Orthopaedic Department (Israel)) ;
Liebergall, Meir (Hadassah - Hebrew University Medical Center. Orthopaedic Department (Israel)) ;
Prada, María E. (I.E.S.O. 'Los Salados'. Junta de Castilla y León) ;
Vidal, Julio M. (Junta de Castilla y León. Servicio de Cultura de León) ;
Gronostajski, Richard M. (University at Buffalo. Jacobs School of Medicine and Biomedical Sciences. Department of Biochemistry (USA)) ;
Stone, Anne C. (Arizona State University. Institute of Human Origins) ;
Yakir, Benjamin (The Hebrew University of Jerusalem. Department of Statistics (Israel)) ;
Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Pinhasi, Ron (University of Vienna. Department of Evolutionary Anthropology (Austria)) ;
Reich, David (Howard Hughes Medical Institute. Harvard Medical School (USA)) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
Meshorer, Eran (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences (Israel)) ;
Carmel, Liran (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel))
Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. [...]
2020 - 10.1038/s41467-020-15020-6
Nature communications, Vol. 11 (March 2020) , art. 1189
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27 p, 3.0 MB |
A multiscale model of epigenetic heterogeneity-driven cell fate decision-making
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Folguera Blasco, Núria (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Pérez Carrasco, Rubén (University College London. Department of Mathematics) ;
Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ;
Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ;
Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Centre de Recerca Matemàtica
The inherent capacity of somatic cells to switch their phenotypic status in response to damage stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entryexit mechanisms of phenotype reprogramming are established remains poorly understood. [...]
2019 - 10.1371/journal.pcbi.1006592
PLoS computational biology, Vol. 15, Issue 4 (April 2019) , art. e1006592
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15 p, 620.2 KB |
Endometrial gene expression profile of pregnant sows with extreme phenotypes for reproductive efficiency
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Córdoba, Sarai (Centre de Recerca en Agrigenòmica) ;
Balcells Ortega, Ingrid (Centre de Recerca en Agrigenòmica) ;
Castelló Farré, Anna (Centre de Recerca en Agrigenòmica) ;
Ovilo, Cristina (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya)) ;
Noguera, José Luis (Institut de Recerca i Tecnologia Agroalimentàries) ;
Timoneda i Heredia, Oriol (Centre de Recerca en Agrigenòmica) ;
Sánchez Bonastre, Armando (Centre de Recerca en Agrigenòmica) ;
Centre de Recerca en Agrigenòmica
Prolificacy can directly impact porcine profitability, but large genetic variation and low heritability have been found regarding litter size among porcine breeds. To identify key differences in gene expression associated to swine reproductive efficiency, we performed a transcriptome analysis of sows' endometrium from an Iberian x Meishan F2 population at day 30-32 of gestation, classified according to their estimated breeding value (EBV) as high (H, EBV > 0) and low (L, EBV < 0) prolificacy phenotypes. [...]
2015 - 10.1038/srep14416
Scientific reports, Vol. 5 (October 2015) , art. 14416
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17 p, 263.4 KB |
Genetic Programming for Object Detection : a Two-Phase Approach with an Improved Fitness Function
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Zhang, Mengjie (Victoria University of Wellington (Wellington, Nova Zelanda). School of Mathematics, Statistics and Computer Science) ;
Bhowan, Urvesh (Victoria University of Wellington (Wellington, Nova Zelanda). School of Mathematics, Statistics and Computer Science) ;
Ny, Bunna (Victoria University of Wellington (Wellington, Nova Zelanda). School of Mathematics, Statistics and Computer Science)
This paper describes two innovations that improve the efficiency and effectiveness of a genetic programming approach to object detection problems. The approach uses genetic programming to construct object detection programs that are applied, in a moving window fashion, to the large images to locate the objects of interest. [...]
2007 - 10.5565/rev/elcvia.135
ELCVIA : Electronic Letters on Computer Vision and Image Analysis, V. 6 n. 1 (2007) p. 27-43
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