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1.
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18 p, 1.0 MB |
Polyoxometalate-Decorated Gold Nanoparticles Inhibit β-Amyloid Aggregation and Cross the Blood-Brain Barrier in a µphysiological Model
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Perxés Perich, Marta (Institut Català de Nanociència i Nanotecnologia) ;
Palma-Florez, Sujey (Institut de Ciència i Tecnologia de Barcelona) ;
Solé, Clara (Institut de Ciència i Tecnologia de Barcelona) ;
Goberna-Ferrón, Sara (Institut Català de Nanociència i Nanotecnologia) ;
Samitier, Josep (Institut de Ciència i Tecnologia de Barcelona) ;
Gómez-Romero, Pedro 1959- (Institut Català de Nanociència i Nanotecnologia) ;
Mir, Mònica (Institut de Ciència i Tecnologia de Barcelona) ;
Lagunas, Anna (Institut de Ciència i Tecnologia de Barcelona)
Alzheimer's disease is characterized by a combination of several neuropathological hallmarks, such as extracellular aggregates of beta amyloid (Aβ). Numerous alternatives have been studied for inhibiting Aβ aggregation but, at this time, there are no effective treatments available. [...]
2023 -  10.3390/nano13192697
Nanomaterials, Vol. 13, Issue 19 (October 2023) , art. 2697
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2.
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13 p, 10.6 MB |
Exploiting endocytosis for transfection of mRNA for cytoplasmatic delivery using cationic gold nanoparticles
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Gustà, Muriel F. (Institut Català de Nanociència i Nanotecnologia) ;
Edel, Michael J (Universitat Autònoma de Barcelona) ;
Salazar Montoya, Vivian Angélica (Institut Català de Nanociència i Nanotecnologia) ;
Alvarez-Palomo, Belén (Banc de Sang i Teixits) ;
Juan, Manel (Hospital Clínic i Provincial de Barcelona) ;
Broggini, Massimo (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri) ;
Damia, Giovanna (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri) ;
Bigini, Paolo (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri) ;
Corbelli, Alessandro (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri) ;
Fiordaliso, Fabio (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri) ;
Barbul, Alexander (Tel Aviv University) ;
Korenstein, Rafi (Tel Aviv University) ;
Bastús, Neus G (Institut Català de Nanociència i Nanotecnologia) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Gene therapy holds promise to cure various diseases at the fundamental level. For that, efficient carriers are needed for successful gene delivery. Synthetic 'non-viral' vectors, as cationic polymers, are quickly gaining popularity as efficient vectors for transmitting genes. [...]
2023 - 10.3389/fimmu.2023.1128582
Frontiers in immunology, Vol. 14 (May 2023) , art. 1128582
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3.
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32 p, 1.2 MB |
Biotinylated phosphorus dendrimers as control line in nucleic acid lateral flow tests
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Vidal, Laura (Universitat Autònoma de Barcelona. Departament de Química) ;
Ben Aissa Soler, Alejandra (Universitat Autònoma de Barcelona. Departament de Química) ;
Salabert Sabaté, Jordi (Universitat Autònoma de Barcelona. Departament de Química) ;
Jara, José Juan (Universitat Autònoma de Barcelona. Departament de Química) ;
Vallribera Massó, Adelina (Universitat Autònoma de Barcelona. Departament de Química) ;
Pividori, María Isabel (Universitat Autònoma de Barcelona. Departament de Química) ;
Sebastián Pérez, Rosa Maria (Universitat Autònoma de Barcelona. Departament de Química)
Lateral flow assays (LFA) are an affordable, easy-to-use, qualitative rapid test for clinical diagnosis in nonlaboratory environments and low-resource facilities. The control line of these tests is very important to provide a valid result, confirming that the platform operates correctly. [...]
2020 - 10.1021/acs.biomac.0c00161
Biomacromolecules, Vol. 21, Issue 3 (March 2020) , p. 1315-1323
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4.
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26 p, 1.5 MB |
The Role of common cell culture media supplements on citrate-stabilized gold nanoparticle protein corona formation, aggregation state, and the consequent impact on cellular uptake
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Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Michelini, Sara (University of Salzburg. Department of Biosciences) ;
Moriones, Oscar Hernando (Universitat Autònoma de Barcelona) ;
Patarroyo, Javier (Institut Català de Nanociència i Nanotecnologia) ;
Rosell Aluja, Jordi 1955- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gustà, Muriel F (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vitali, Michele (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martín, Luna (Vall d'Hebron Institut d'Oncologia) ;
Canals, Francesc (Vall d'Hebron Institut d'Oncologia) ;
Duschl, Albert (University of Salzburg. Department of Biosciences) ;
Horejs-Hoeck, Jutta (University of Salzburg. Department of Biosciences) ;
Mondragón, Laura (Institut Català de Nanociència i Nanotecnologia) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Sodium citrate-stabilized gold nanoparticles (AuNPs) are destabilized when dispersed in cell culture media (CCMs). This may promote their aggregation and subsequent sedimentation, or under the proper conditions, their interaction with dispersed proteins can lead to the formation of a NP-stabilizing protein corona. [...]
2022 - 10.1021/acs.bioconjchem.2c00232
Bioconjugate chemistry, Vol. 33, issue 8 (Aug. 2022) , p. 1505-1514
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5.
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17 p, 7.0 MB |
Differential Radiosensitizing Effect of 50 nm Gold Nanoparticles in Two Cancer Cell Lines
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Pérez-Amor, Miguel Ángel (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Barrios, Leonardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Armengol Rosell, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Barquinero, Joan Francesc (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Radiation therapy is widely used as an anti-neoplastic treatment despite the adverse effects it can cause in non-tumoral tissues. Radiosensitizing agents, which can increase the effect of radiation in tumor cells, such as gold nanoparticles (GNPs), have been described. [...]
2022 - 10.3390/biology11081193
Biology, Vol. 11, Issue 8 (August 2022) , art. 1193
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6.
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13 p, 2.6 MB |
Immunomagnetic separation improves the detection of mycobacteria by paper-based lateral and vertical flow immunochromatographic assays
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Ben Aissa Soler, Alejandra (Universitat Autònoma de Barcelona. Departament de Química) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Zanoni, Maria Valnice (São Paulo State University. Department of Analytical Chemistry) ;
Pividori, María Isabel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
This work addresses a method that combines immunomagnetic separation (IMS) and paperbased nucleic acid immunochromatographic assay for the sensitive detection of Mycolicibacterium fortuitum (basonym Mycobacterium fortuitum) In particular, the preconcentration of the bacteria was achieved by using magnetic particles modified with an antibody specific towards mycobacteria. [...]
2021 - 10.3390/s21185992
Sensors (Basel, Switzerland), Vol. 21, Issue 18 (September 2021) , art. 5992
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7.
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17 p, 4.0 MB |
Pharmacokinetics, biodistribution, and biosafety of PEGylated gold nanoparticles in vivo
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Kozics, Katarina (Biomedical Research Center SAS (Bratislava, Eslovàquia). Department of Nanobiology) ;
Sramkova, Monika (Biomedical Research Center SAS (Bratislava, Eslovàquia). Department of Nanobiology) ;
Kopecka, Kristina (Biomedical Research Center SAS (Bratislava, Eslovàquia). Department of Nanobiology) ;
Begerova, Patricia (Biomedical Research Center SAS (Bratislava, Eslovàquia). Department of Nanobiology) ;
Manova, Alena (Slovak University of Technology in Bratislava. Institute of Analytical Chemistry) ;
Krivosikova, Zora (Slovak Medical University in Bratislava. Department of Clinical and Experimental Pharmacotherapy) ;
Sevcikova, Zuzana (University of Veterinary Medicine and Pharmacy in Kosice. Department of Morphological Disciplines) ;
Liskova, Aurelia (Slovak Medical University in Bratislava. Laboratory of Immunotoxicology) ;
Rollerová, Eva (Slovak Medical University in Bratislava. Laboratory of Toxicology) ;
Dubaj, Tibor (Slovak University of Technology in Bratislava. Institute of Physical Chemistry and Chemical Physics) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Wsolova, Ladislava (Slovak Medical University in Bratislava. Laboratory of Toxicology) ;
Šimon, Peter (Slovak University of Technology in Bratislava. Institute of Physical Chemistry and Chemical Physics) ;
Tulinska, Jana (Slovak Medical University in Bratislava. Laboratory of Immunotoxicology) ;
Gabelova, Alena (Biomedical Research Center SAS. Department of Nanobiology)
Despite the obvious advantages of gold nanoparticles for biomedical applications, controversial and incomplete toxicological data hamper their widespread use. Here, we present the results from an in vivo toxicity study using gold nanoparticles coated with polyethylene glycol (PEG-AuNPs). [...]
2021 - 10.3390/nano11071702
Nanomaterials, Vol. 11, issue 7 (July 2021) , art. 1702
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8.
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12 p, 1.1 MB |
Pharmacokinetics of PEGylated gold nanoparticles : in vitro-in vivo correlation
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Dubaj, Tibor (Slovak University of Technology in Bratislava. Institute of Physical Chemistry and Chemical Physics) ;
Kozics, Katarina (Biomedical Research Center SAS. Cancer Research Institute (Bratislava, Eslovàquia)) ;
Sramkova, Monika (Biomedical Research Center SAS. Cancer Research Institute (Bratislava, Eslovàquia)) ;
Manova, Alena (Biomedical Research Center SAS. Cancer Research Institute (Bratislava, Eslovàquia)) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Moriones, Oscar Hernando (Institut Català de Nanociència i Nanotecnologia) ;
Kohl, Yvonne (Fraunhofer Institute for Biomedical Engineering) ;
Dusinska, Maria (Norwegian Institute for Air Research. Health Effects Laboratory) ;
Rundén-Pran, Elise (Norwegian Institute for Air Research. Health Effects Laboratory) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Nelson, Andrew (University of Leeds. School of Chemistry) ;
Gabelova, Alena (Biomedical Research Center SAS. Cancer Research Institute (Bratislava, Eslovàquia)) ;
Šimon, Peter (Slovak University of Technology in Bratislava. Institute of Physical Chemistry and Chemical Physics)
Data suitable for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) remain relatively scarce. Therefore, there is a trend in extrapolating the results of in vitro and in silico studies to in vivo nanoparticle hazard and risk assessment. [...]
2022 - 10.3390/nano12030511
Nanomaterials, Vol. 12, issue 3 (Feb. 2022) , art. 511
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9.
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10.
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16 p, 2.4 MB |
Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold : An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine
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Gutiérrez-Carcedo, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navalón, Sergio (Universidad Politécnica de Madrid) ;
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Setoain, Xavier (Hospital Clínic i Provincial de Barcelona) ;
Aparicio-Gómez, Carolina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Victor, Victor Manuel (Universitat de València) ;
García, Hermenegildo (Universidad Politécnica de Madrid) ;
Herance, José Raul (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Ceria nanoparticles are cell compatible antioxidants whose activity can be enhanced by gold deposition and by surface functionalization with positive triphenylphosphonium units to selectively target the mitochondria. [...]
2020 - 10.3390/nano10040744
Nanomaterials, Vol. 10 (april 2020)
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