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1.
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15 p, 6.1 MB |
Polystyrene nanoplastics target lysosomes interfering with lipid metabolism through the PPAR system and affecting macrophage functionalization
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Brandts, Irene (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Solà, Roger (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Garcia Ordoñez, Marlid (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gella, Alejandro (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Martin, Beatriz (Centre de Regulació Genòmica) ;
Esteve-Codina, Anna (Universitat Pompeu Fabra) ;
Teles, Mariana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Nanoplastics (NPs) are currently a main concern for environmental, animal and human health due to their potential to accumulate in different environmental compartments and provoke effects in living organisms. [...]
2023 -  10.1039/d2en01077a
Environmental science. Nano, Vol. 10, Issue 9 (September 2023) , p. 2245-2258
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2.
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17 p, 10.0 MB |
Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio -Stimulated Sea Urchin Immune Cells
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Alijagic, Andi (Istituto per la Ricerca e l'Innovazione Biomedica) ;
Bonura, Angela (Istituto per la Ricerca e l'Innovazione Biomedica) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Gervasi, Francesco (Hospitals Civico Di Cristina e Benfratelli) ;
Pinsino, Annalisa (Istituto per la Ricerca e l'Innovazione Biomedica)
We investigated the role of the gold nanoparticles functionalized with polyvinylpyrrolidone (PVP-AuNPs) on the innate immune response against an acute infection caused by Vibrio anguillarum in an in vitro immunological nonmammalian next-generation model, the sea urchin Paracentrotus lividus. [...]
2021 - 10.3390/nano11102646
Nanomaterials, Vol. 11, Issue 10 (October 2021) , art. 2646
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3.
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32 p, 4.2 MB |
Cross-species comparisons of nanoparticle interactions with innate immune systems : a methodological review
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Swartzwelter, Benjamin (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia)) ;
Mayall, Craig (University of Liubljana. Department of Biology) ;
Alijagic, Andi (Istituto per la Ricerca e l'Innovazione Biomedica (Palerm, Itàlia)) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Ferrari, Eleonora (ZMBP Eberhard-Karls University Tübingen. Center for Plant Molecular Biology) ;
Hernadi, Szabolcs (Cardiff University. School of Biosciences) ;
Michelini, Sara (Paris-Lodron University Salzburg. Department of Biosciences) ;
Navarro Pacheco, Natividad Isabel (Institute of Microbiology of the Czech Academy of Sciences) ;
Prinelli, Alessandra (AvantiCell Science, Ltd.) ;
Swart, Elmer (UK Centre for Ecology and Hydrology (Wallingford, Regne Unit)) ;
Auguste, Manon (Università degli Studi di Genova. Dipartimento di Ambiente terrestre e scienze della vita)
Many components of the innate immune system are evolutionarily conserved and shared across many living organisms, from plants and invertebrates to humans. Therefore, these shared features can allow the comparative study of potentially dangerous substances, such as engineered nanoparticles (NPs). [...]
2021 - 10.3390/nano11061528
Nanomaterials, Vol. 11, issue 6, art. 1528 (June 2021)
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4.
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10 p, 389.9 KB |
A phase II study of human allogeneic liver-derived progenitor cell therapy for acute-on-chronic liver failure and acute decompensation
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Nevens, Frederik (University Hospitals Leuven (Bèlgica)) ;
Gustot, Thierry (C.U.B. Erasme Hospital) ;
Laterre, Pierre-François (Cliniques Universitaires Saint-Luc) ;
Lasser, Luc L. (CHU Brugmann) ;
Haralampiev, Lyudmil E. (Multiprofile Hospital for Active Treatment (MEDICA), Ruse) ;
Vargas, Victor (Hospital Universitari Vall d'Hebron) ;
Lyubomirova, Desislava (University Multiprofile Hospital for Active Treatment "Georgi Stranski") ;
Albillos, Agustín (Hospital Universitario Ramón y Cajal (Madrid)) ;
Najimi, Mustapha (Institute of Experimental and Clinical Research, Brussels) ;
Michel, Sébastien (Promethera Biosciences, Mont-Saint-Guibert) ;
Stoykov, Ivaylo (Promethera Biosciences, Mont-Saint-Guibert) ;
Gordillo, Noelia (Promethera Biosciences, Mont-Saint-Guibert) ;
Vainilovich, Yelena (Promethera Biosciences, Mont-Saint-Guibert) ;
Barthel, Virginie (Promethera Biosciences, Mont-Saint-Guibert) ;
Clerget-Chossat, Nathalie (Promethera Biosciences, Mont-Saint-Guibert) ;
Sokal, Etienne M. (Cliniques Universitaires Saint-Luc, UCLouvain, Pediatric Hepatology & Gastroenterology Unit) ;
Universitat Autònoma de Barcelona
Human allogeneic liver-derived progenitor cells (HALPC, HepaStem®; Promethera Biosciences, Mont-Saint-Guibert, Belgium) are an advanced therapy medicinal product that could potentially alleviate systemic inflammation and ameliorate liver function in patients with acute-on-chronic liver failure (ACLF) or acute decompensation of cirrhosis (AD). [...]
2021 - 10.1016/j.jhepr.2021.100291
JHEP Reports, Vol. 3 (april 2021)
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5.
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13 p, 3.9 MB |
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
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Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Calero-Nieto, Fernando (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Wang, X. (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Valdés-Mas, Rafael (Dreamgenics S.L. Oviedo) ;
Gutiérrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roca Ho, Heleia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ayllon, Veronica (Centro Pfizer - Universidad de Granada - Junta de Andalucía de Genómica e Investigación Oncológica) ;
Real, P. J. (Centro Pfizer - Universidad de Granada - Junta de Andalucía de Genómica e Investigación Oncológica) ;
Arambilet Mobilla, David (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Varela, Ignacio (Universidad de Cantabria. Departamento de Biología Molecular) ;
De Boer, J. (University College London Great Ormond Street Institute of Child Health. Cancer Section) ;
Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gottgens, B. (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Marschalek, Rolf (Institute of Pharmaceutical Biology. Goethe-University) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the t(4;11)-resulting MLL-AF4 (MA4) and AF4-MLL (A4M) fusions remains unclear; MA4 is always expressed in patients with t(4;11)+ B-cell acute lymphoblastic leukemia, but the reciprocal fusion A4M is expressed in only half of the patients. [...]
2019 - 10.3324/haematol.2018.202044
Haematologica, Vol. 104 Núm. 6 (2019) , p. 1189-1201
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6.
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17 p, 326.4 KB |
Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder : lessons from CNTNAP2, ADGRL3, and PARK2
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Dalla Vecchia, Elisa (Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK) ;
Mortimer, Niall (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Palladino, Viola S. (University Hospital of Frankfurt (Alemanya)) ;
Kittel-Schneider, Sarah (University Hospital of Frankfurt (Alemanya)) ;
Lesch, Klaus-Peter (Department of Translational Neuroscience, School of Mental Health and Neuroscience, Maastricht University, Maastricht) ;
Reif, Andreas (University Hospital of Frankfurt (Alemanya)) ;
Schenck, Annette (Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands) ;
Norton, William H. J. (Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK) ;
Universitat Autònoma de Barcelona
Animal and cellular models are essential tools for all areas of biological research including neuroscience. Model systems can also be used to investigate the pathophysiology of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). [...]
2018 - 10.1097/YPG.0000000000000211
Psychiatric Genetics, Vol. 29 (november 2018) , p. 1-17
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7.
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8 p, 2.1 MB |
Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis
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Zabalza, Ana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Vera, Andrea (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Alari-Pahissa, Elisenda (Universitat Pompeu Fabra) ;
Munteis, Elvira (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Moreira Villanueva, Antía (Althaia Xarxa Assistencial Universitària de Manresa) ;
Yélamos, José (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Llop, Mireia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
López-Botet, Miguel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martínez-Rodríguez, Jose E. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in MS patients whether HCMV induces modifications in the peripheral B cell compartment. [...]
2020 - 10.1186/s12974-020-01840-2
Journal of neuroinflammation, Vol. 17 (may 2020)
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8.
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14 p, 2.3 MB |
Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect
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Anglada Pons, Teresa (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Repullés Fernández, Joan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Espinal Berenguer, Anna (Universitat Autònoma de Barcelona. Servei d'Estadística Aplicada) ;
LaBarge, Mark A. (Lawrence Berkeley National Laboratory) ;
Stampfer, Martha R. (Lawrence Berkeley National Laboratory) ;
Genescà, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martín Flix, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Institut d'Investigació Biomèdica Sant Pau
Aging is a degenerative process in which genome instability plays a crucial role. To gain insight into the link between organismal aging and DNA repair capacity, we analyzed DNA double-strand break (DSB) resolution efficiency in human mammary epithelial cells from 12 healthy donors of young and old ages. [...]
2019 - 10.18632/aging.101849
Aging (Albany NY), Vol. 11, Num. 5 (March 2019) , p. 1510-1523
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9.
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20 p, 3.2 MB |
Expression of Melatonin and Dopamine D Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension
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Reyes-Resina, Irene (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Awad Alkozi, Hanan (University Complutense of Madrid. Faculty of Optics and Optometry. Department of Biochemistry) ;
del Ser Badia, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Sánchez-Naves, Juan (Institut d'Oftalmologia de les Illes Balears) ;
Lillo, Jaume (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Jiménez, Jasmina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pintor, Jesús (University Complutense of Madrid. Faculty of Optics and Optometry. Department of Biochemistry and Molecular Biology) ;
Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Franco, Rafael (Universitat de Barcelona. Facultat de Química) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Background: Experiments in the late nineties showed an inverse relationship in the eye levels of melatonin and dopamine, thereby constituting an example of eye parameters that are prone to circadian variations. [...]
2020 - 10.3390/cells9010152
Cells, Vol. 9, Num. 1 (January 2020) , art. 152
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10.
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22 p, 4.3 MB |
Cerium oxide nanoparticles protect against oxidant injury and interfere with oxidative mediated kinase signaling in human-derived hepatocytes
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Carvajal, Silvia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Perramón, Meritxell (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Casals, Gregori (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Oró, Denise (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ribera, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Morales Ruiz, Manuel (Universitat de Barcelona. Departament de Biomedicina) ;
Casals, Eudald (Wuyi University. School of Biotechnology and Health Sciences) ;
Casado, Pedro (Queen Mary University of London) ;
Melgar Lesmes, Pedro (Universitat de Barcelona. Departament de Biomedicina) ;
Fernández-Varo, Guillermo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cutillas, Pedro (Queen Mary University of London) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Jiménez, Wladimiro (Universitat de Barcelona. Departament de Biomedicina)
Cerium oxide nanoparticles (CeO NPs) possess powerful antioxidant properties, thus emerging as a potential therapeutic tool in non-alcoholic fatty liver disease (NAFLD) progression, which is characterized by a high presence of reactive oxygen species (ROS). [...]
2019 - 10.3390/ijms20235959
International journal of molecular sciences, Vol. 20, Issue 23 (December 2019) , art. 5959
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