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Results overview: Found 24 records in 0.03 seconds.
Articles, 15 records found
Research literature, 9 records found
Articles 15 records found  1 - 10next  jump to record:
1.
10 p, 1.9 MB Efficient controlled release of cannabinoids loaded in γ‑CD‑MOFs and DPPC liposomes as novel delivery systems in oral health / Rodriguez Martinez, Jorge (Universitat Autònoma de Barcelona. Departament de Química) ; Sánchez-Martín, María-Jesús (Universitat Autònoma de Barcelona. Departament de Química) ; Valiente Malmagro, Manuel (Universitat Autònoma de Barcelona. Departament de Química)
Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS) for dental hypersensitivity (DH) treatment. [...]
2023 - 10.1007/s00604-023-05692-4
Mikrochimica acta, Vol. 190 (March 2023) , art. 125  
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2.
21 p, 2.4 MB Selective brain entry of lipid nanoparticles in haemorrhagic stroke is linked to biphasic blood-brain barrier disruption / Al-Ahmady, Zahraa S. (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ; Dickie, Ben R. (University of Manchester. Geoffrey Jefferson Brain Research Centre) ; Aldred, Isabelle (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ; Jasim, Dhifaf A. (The University of Manchester. Nanomedicine Lab, Division of Pharmacy and Optometry) ; Barrington, Jack (University of Manchester. Division of Neuroscience and Experimental Psychology) ; Haley, Michael J (University of Manchester. Division of Neuroscience and Experimental Psychology) ; Lemarchand, Eloise (University of Manchester. Division of Neuroscience and Experimental Psychology) ; Coutts, Graham (University of Manchester. Division of Neuroscience and Experimental Psychology) ; Kaur, Satinderdeep (Nottingham Trent University. Pharmacology Department) ; Bates, Jessica (Nottingham Trent University. Pharmacology Department) ; Curran, Sarah (Nottingham Trent University. Pharmacology Department) ; Goddard, Ruth (Nottingham Trent University. Pharmacology Department) ; Walker, Megan (Nottingham Trent University. Pharmacology Department) ; Parry-jones, Adrian (University of Manchester. Geoffrey Jefferson Brain Research Centre) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Allan, Stuart M. (University of Manchester. Geoffrey Jefferson Brain Research Centre)
Haemorrhagic stroke represents a significant public health burden, yet our knowledge and ability to treat this type of stroke are lacking. Previously we showed that we can target ischaemic-stroke lesions by selective translocation of lipid nanoparticles through the site of blood-brain barrier (BBB) disruption. [...]
2022 - 10.7150/thno.72167
Theranostics, Vol. 12, Issue 10 (May 2022) , p. 4477-4497  
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3.
10 p, 3.6 MB Tooth whitening effects on dental enamel, oxidation or reduction? Comparison of physicochemical alterations in bovine enamel using Synchrotron-based Micro-FTIR / Babot Marquillas, Clara (Universitat Autònoma de Barcelona. Departament de Química) ; Sánchez-Martín, María-Jesús (Universitat Autònoma de Barcelona. Departament de Química) ; Amigo, Jose Manuel (Universidad del País Vasco. Departamento de Química Analítica) ; Yousef, Ibraheem (ALBA Laboratori de Llum de Sincrotró) ; Valido, Iris H. (Universitat Autònoma de Barcelona. Departament de Química) ; Boada, Roberto (Universitat Autònoma de Barcelona. Departament de Química) ; Valiente Malmagro, Manuel (Universitat Autònoma de Barcelona. Departament de Química)
Objectives: To compare the side effects of typical whitening treatments (by means of oxidation) compared to the new treatment developed by the authors through reduction. The aim is to provide information about the chemical interactions of the encapsulated reductant agent (metabisulfite, MBS) with the enamel structure compared with carbamide peroxide (CP) and to study their penetration in the hydroxyapatite (HAP) and the changes produced in the mineral and its hardness. [...]
2022 - 10.1016/j.dental.2022.02.006
Dental Materials, Vol. 38, issue 4 (April 2022) , p. 670-679  
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4.
15 p, 7.1 MB Application of Quality by Design to the robust preparation of a liposomal GLA formulation by DELOS-susp method / Merlo-Mas, Josep (Nanomol Technologies S.L.) ; Tomsen-Melero, Judit (Institut de Ciència de Materials de Barcelona) ; Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González Mira, Elisabet (Institut de Ciència de Materials de Barcelona) ; Font, Albert (Leanbio S.L.) ; Pedersen, Jannik N. (Aarhus University. Department of Chemistry and Interdisciplinary Nanoscience Center (iNANO) (Denmark)) ; García Aranda, Natalia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cristóbal-Lecina, Edgar (Institut de Química Avançada de Catalunya) ; Alcaina-Hernando, Marta (Nanomol Technologies S.L.) ; Mendoza, Rosa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Garcia-Fruitos, Elena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lizarraga, Teresa (Leanbio S.L.) ; Resch, Susanne (BioNanoNet Forschungsgesellschaft mbH (Austria)) ; Schimpel, Christa (BioNanoNet Forschungsgesellschaft mbH (Austria)) ; Falk, Andreas (BioNanoNet Forschungsgesellschaft mbH (Austria)) ; Pulido, Daniel (Institut de Química Avançada de Catalunya) ; Royo, Miriam (Institut de Química Avançada de Catalunya) ; Schwartz, Simó (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pedersen, Jan Skov (Aarhus University. Department of Chemistry and Interdisciplinary Nanoscience Center (iNANO) (Denmark)) ; Danino, Dganit (Technion - Israel Institute of Technology. CryoEM Laboratory of Soft Matter) ; Soldevila, Andreu (Leanbio S.L.) ; Veciana i Miró, Jaume (Institut de Ciència de Materials de Barcelona) ; Sala, Santi (Nanomol Technologies S.L.) ; Ventosa, Nora (Institut de Ciència de Materials de Barcelona) ; Córdoba, Alba (Nanomol Technologies S.L.)
Fabry disease is a lysosomal storage disease arising from a deficiency of the enzyme α-galactosidase A (GLA). The enzyme deficiency results in an accumulation of glycolipids, which over time, leads to cardiovascular, cerebrovascular, and renal disease, ultimately leading to death in the fourth or fifth decade of life. [...]
2021 - 10.1016/j.supflu.2021.105204
The Journal of Supercritical Fluids, Vol. 173 (July 2021) , art. 105204  
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5.
50 p, 4.9 MB Intracerebral injection of graphene oxide nanosheets mitigates microglial activation without inducing aAcute neurotoxicity : a pilot comparison to other nanomaterials / Portioli, Corinne (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences) ; Bussy, Cyrill (Lydia Becker Institute of Immunology and Inflammation) ; Mazza, Mariarosa (The University of Manchester. Nanomedicine Lab.) ; Lozano, Neus (Institut Català de Nanociència i Nanotecnologia) ; Jasim, Dhifaf A. (The University of Manchester. Nanomedicine Lab.) ; Prato, Maurizio (Ikerbasque) ; Bianco, Alberto (CNRS. University of Strasbourg. Immunology, Immunopathology and Therapeutic Chemistry) ; Bentivoglio, Marina (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Carbon-based nanomaterials (CNMs) are being explored for neurological applications. However, systematic in vivo studies investigating the effects of CNM nanocarriers in the brain and how brain cells respond to such nanomaterials are scarce. [...]
2020 - 10.1002/smll.202004029
Small, Vol. 16, issue 48 (Dec. 2020) , art. 2004029  
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6.
24 p, 881.4 KB Nano-scavengers for blood biomarker discovery in ovarian carcinoma / Hadjidemetriou, Marilena (The University of Manchester. Nanomedicine Lab) ; Papafilippou, Lana (The University of Manchester. Nanomedicine Lab) ; Unwin, Richard D. (The University of Manchester. Division of Cardiovascular Sciences) ; Rogan, Jane (Manchester Cancer Research Centre Biobank) ; Clamp, Andrew (The University of Manchester. Manchester Cancer Research Centre) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
The development and implementation of biomarker-based screening tools for ovarian cancer require novel analytical platforms to enable the discovery of biomarker panels that will overcome the limitations associated with the clinically used CA-125. [...]
2020 - 10.1016/j.nantod.2020.100901
Nano Today, Vol. 34 (Oct. 2020) , art. 100901  
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7.
23 p, 654.0 KB Protein corona fingerprinting to differentiate sepsis from non-infectious systemic inflammation / Papafilippou, Lana (The University of Manchester. Nanomedicine Lab.) ; Claxton, Andrew (Manchester Academic Health Science Centre. Centre for Acute Care Trauma) ; Dark, Paul (Manchester Academic Health Science Centre. Centre for Acute Care Trauma) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia) ; Hadjidemetriou, Marilena (University of Manchester. Nanomedicine Lab.)
Rapid and accurate diagnosis of sepsis remains clinically challenging. The lack of specific biomarkers that can differentiate sepsis from non-infectious systemic inflammatory diseases often leads to excessive antibiotic treatment. [...]
2020 - 10.1039/d0nr02788j
Nanoscale, Vol. 12, issue 18 (2020) , p. 10240-10253  
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8.
24 p, 1.8 MB LipoBots : using liposomal vesicles as protective shell of urease-based nanomotors / Hortelão, A. C. L. (Institut de Bioenginyeria de Catalunya) ; García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Patiño, Tania (Institut de Bioenginyeria de Catalunya) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Sánchez Ordóñez, Samuel (Institució Catalana de Recerca i Estudis Avançats)
Developing self-powered nanomotors made of biocompatible and functional components is of paramount importance in future biomedical applications. Herein, the functional features of LipoBots (LBs) composed of a liposomal carrier containing urease enzymes for propulsion, including their protective properties against acidic conditions and their on-demand triggered activation, are reported. [...]
2020 - 10.1002/adfm.202002767
Advanced functional materials, Vol. 30, issue 42 (Oct. 2020) , art. 2002767  
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9.
12 p, 5.0 MB Biodistribution of liposome-encapsulated bacteriophages and their transcytosis during oral phage therapy / Otero Carrera, Jennifer (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; García-Rodríguez, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Cortés Garmendia, M. Pilar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Llagostera Casas, Montserrat (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
This study sheds light on the biodistribution of orally administered, liposome-encapsulated bacteriophages, and their transcytosis through intestinal cell layers. Fluorochrome-labeled bacteriophages were used together with a non-invasive imaging methodology in the in vivo visualization of bacteriophages in the stomach and intestinal tract of mice. [...]
2019 - 10.3389/fmicb.2019.00689
Frontiers in microbiology, Vol. 10 (April 2019) , art. 689  
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10.
12 p, 2.5 MB Liposome-based immunotherapy against autoimmune diseases : Therapeutic effect on multiple sclerosis / Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mansilla Lopez, Maria Jose (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rius, Aleix (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ; Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. [...]
2017 - 10.2217/nnm-2016-0410
Nanomedicine, Vol. 12, Issue 11 (June 2017) , p. 1231-1242  
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Articles : 15 records found   1 - 10next  jump to record:
Research literature 9 records found  
1.
302 p, 17.1 MB Metallosurfactants and drug delivery systems for biomedical applications / Garcia Ortega, Glòria ; Palacios Bonilla, Òscar, dir. ; Bayón, Joan Carles, dir.
Un gran nombre de fàrmacs basats en platí són utilitzats com a agents antineoplàstics per al tractament de diversos càncers. Tot i això, els efectes adversos relacionats amb aquest tipus de teràpies crea la necessitat de millorar els sistemes d'alliberament de fàrmacs. [...]
Un gran número de fármacos basados en el platino se utilizan como agentes antineoplásicos para el tratamiento de varios cánceres. Sin embargo, los efectos adversos de este tipo de terapias generan la necesidad de mejorar los sistemas de transporte y liberación de fármacos. [...]
Platinum drugs are widely used as antineoplastic agents in the treatment of several cancers. However, pernicious side effects related to the systemic toxicity of these types of therapies enforce the improvement of drug delivery systems. [...]
2022  
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2.
345 p, 14.0 MB Study of New Liposomes for the Delivery of Enzymes through Biological Membranes / Tomsen Melero, Judit ; González Mira, Elisabet, dir. ; Ventosa, Nora, dir.
Els liposomes són nanovesícules lipídiques àmpliament explorades per ser utilitzades com a transportadors d'actius terapèutics per al desenvolupament de noves nanomedicines. En la present Tesi s'ha estudiat l'ús d'aquests sistemes liposomals funcionalitzats amb lligands per ser utilitzats com a nanotransportadors d'enzims, específicament, pel transport eficaç de l'enzim α-galactosidasa a través de les membranes biològiques, com la membrana cel·lular o la barrera hematoencefàlica, per tal d'aconseguir un nou producte farmacèutic pel tractament de la malaltia de Fabry. [...]
Los liposomas son nanovesículas lipídicas ampliamente exploradas para ser utilizadas como transportadores de activos terapéuticos para el desarrollo de nuevas nanomedicinas. En la presente Tesis se ha estudiado el uso de estos sistemas liposomales funcionalizados con ligandos para ser utilizados como nanotransportadores de enzimas, específicamente, para el transporte eficaz de la enzima α-galactosidasa a través de membranas biológicas, como la membrana celular o la barrera hematoencefálica, para conseguir un nuevo producto farmacéutico para el tratamiento de la enfermedad de Fabry. [...]
Liposomes are lipid-based nanovesicles widely explored as nanocarriers for the transport of biomolecules or drugs of interest to the place of action and for the development of new nanomedicines. This Thesis is devoted to the study of liposomal systems functionalized with targeting-ligands, with the final goal to be used as nanocarriers of therapeutically active enzymes. [...]
2021  
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3.
146 p, 16.9 MB A novel approach for tooth whitening : liposome-encapsulated reductant. In vitro efficacy studies and characterization of the treated teeth including synchrotron techniques / Babot Marquillas, Clara ; Valiente Malmagro, Manuel, dir. ; Sánchez Martín, Ma. Jesús, dir.
En aquesta tesi es conceptualitza, desenvolupa i optimitza un tractament blanquejant per a la seva aplicació a la cavitat oral, basat en un enfocament diferent a la oxidació. També s'estudien els seus efectes sobre l'estructura dental. [...]
En esta tesis se conceptualiza, desarrolla y optimiza un tratamiento blanqueante para su aplicación en la cavidad oral, basado en un enfoque diferente a la oxidación. También se estudian sus efectos sobre la estructura dental. [...]
In this thesis, a treatment based on a different approach is conceptualized, developed and optimized for its application in the oral cavity. Also, its effects over the tooth structure are studied. It was hypothesized that the reducing agent sodium metabisulphite (MBS) had whitening action over the tooth stains, by saturation of the conjugated double bonds. [...]
2021  
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4.
195 p, 6.8 MB Peptide functionalized nanoliposomes for biomolecule intracellular delivery, prepared using compressed CO2 / Bueno López, Dolores ; González Mira, Elisabet, dir. ; Ventosa, Nora, dir. ; Guirado López, Gonzalo, dir.
La malaltia de Fabry és un trastorn d'emmagatzematge lisosòmic (LSD), una malaltia rara causada per una mutació gènica en el cromosoma X, que codifica l'enzim α-galactosidasa A (GLA). La GLA hidrolitza els residus α-D-galactosils terminals de glicosfingolípids neutres. [...]
La enfermedad de Fabry es un trastorno de almacenamiento lisosomal (LSD), una enfermedad rara causada por una mutación genética en el cromosoma X, que codifica la enzima α-galactosidasa A (GLA). La GLA hidroliza los residuos terminales de α-D-galactosilo a partir de glicosfingolípidos neutros. [...]
Fabry disease is a lysosomal storage disorder (LSD), a rare disease caused by a gene mutation on the X-chromosome, which encodes α-galactosidase A (GLA) enzyme. The GLA hydrolyzes terminal α-D-galactosyl residuals from neutral glycosphingolipids. [...]
2020  
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5.
280 p, 7.9 MB Phosphatidylserine-rich liposomes to tackle autoimmunity : en route to translationality / Rodríguez Fernández, Silvia ; Vives Pi, Marta, dir. ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Les malalties autoimmunitàries estan causades per defectes en la tolerància immunològica, i afecten a gairebé un 10% de la població. Darrerament, diverses intervencions mèdiques han convertit aquestes malalties en cròniques, però el seu diagnòstic encara comporta morbiditat i mortalitat elevades. [...]
Autoimmune diseases are caused by defective immunological tolerance, and reportedly affect up to 10% of the global population. In the last years, current medical interventions have transformed these disorders into chronic and manageable, but they still entail high rates of morbidity and mortality. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
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6.
108 p, 5.8 MB Metal·lotensioactius i fosfolípids : estudi d'agegats supramoleculars com a sistemes alliberadors de monòxid de carboni / Marín García, Maribel ; Barnadas Rodríguez, Ramon, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Suades Ortuño, Joan, dir. (Universitat Autònoma de Barcelona. Departament de Química) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
El monòxid de carboni ha estat considerat tradicionalment com un potent tòxic de naturalesa letal principalment degut a la seva gran afinitat amb l'hemoglobina, unes 220 vegades major que l'afinitat de l'Hb per l'oxigen. [...]
Carbon monoxide (CO) has long been considered as a toxic gas to human health because of its lethal nature, causing death by asphyxia. The toxicity of CO is attributed in part to its high affinity for hemoglobin (Hb), which is about 220 times higher than that of Hb for O2. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2017.
3 documents
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7.
294 p, 7.4 MB Cholesterol and compressed CO2 : a smart molecular building block and advantageous solvent to prepare stable self-assembled colloidal nanostructures / Ferrer Tasies, Lidia Priscila ; Ricart, Susana, dir. (Institut de Ciència de Materials de Barcelona) ; Ventosa, Nora, dir. (Institut de Ciència de Materials de Barcelona) ; Pleixats i Rovira, Roser, dir. (Universitat Autònoma de Barcelona. Departament de Química) ; Universitat Autònoma de Barcelona. Departament de Química
La fabricación ascendente de nanoestructuras supramoleculares definidas es clave para el desarrollo de nuevos materiales funcionales basados en sistemas autoensamblados. En este marco, los liposomas son algunos de los nanoobjetos autoensamblados más estudiados desde su descubrimiento fortuito en 1964. [...]
The bottom-up fabrication of defined supramolecular nanostructures is key to the development of novel functional materials based on self-assembling systems. In this regard, liposomes are among the most studied self-assembled nanoobjects since their serendipitous discovery in 1964. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2016  
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8.
1 p, 2.1 MB Immunoliposomes state of the art : pharmacokinetics of a novel drug delivery system for cancer treatment / García Pagès, Esther ; Vivas Sabido, Nuria María, dir. (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Grau en Ciències Biomèdiques [832]  
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9.
133 p, 10.1 MB Optimització de formulacions amb fosfolípids per a ús dermatològic / Barnadas Rodríguez, Ramon (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sabés Xamaní, Manuel, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
El treball descriu, principalment, la preparació de suspensions de liposomes (L) amb diferents fàrmacs encapsulats (ditranol: DT; hidrocortisona: HC; i butirat-propionat d'hidrocortisona:HBP) així com la d'emulsions o/w amb oli de borratja (OB/aigua) estabilitzades amb fosfolípids (F). [...]
El trabajo describe, principalmente, la preparación de suspensiones de liposomas (L) con diferentes fármacos encapsulados (ditranol: DT; hidrocortisona: HC; y butirato-propionato de hidrocortisona:HBP) así como la de emulsiones o/w con aceite de borrajas (OB/agua) estabilizadas con fosfolípidos (F). [...]
This work describes the preparation of drug-loaded liposome (dithranol: DT; hydrocortisone: HC; hydrocortisone butyrate-propionate: HBP) liposome (L) suspensions and o/w phopholipid stabilized emulsions (borage oil: BO/water). [...]
Bellaterra : Universitat Autònoma de Barcelona, 2009
3 documents
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