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Resultats globals: 9 registres trobats en 0.04 segons.
Articles, 8 registres trobats
Documents de recerca, 1 registres trobats
Articles 8 registres trobats  
1.
22 p, 1.4 MB Understanding MAPK signaling pathways in apoptosis / Yue, Jicheng (Soochow University Medical College. School of Biology and Basic Medical Sciences) ; López, José M. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus. [...]
2020 - 10.3390/ijms21072346
International journal of molecular sciences, Vol. 21 Núm. 7 (march 2020) , p. 2346  
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2.
15 p, 2.0 MB MiR-204 silencing in intraepithelial to invasive cutaneous squamous cell carcinoma progression / Toll Abelló, Agustí (Institut Hospital del Mar d'Investigacions Mèdiques) ; Salgado Sánchez, Rocío Nieves (Hospital del Mar (Barcelona, Catalunya)) ; Espinet, Blanca (Hospital del Mar (Barcelona, Catalunya)) ; Diaz-Lagares, Angel (Institut d'Investigació Biomèdica de Bellvitge) ; Hernández-Ruiz, Eugenia (Hospital Universitari Vall d'Hebron) ; Andrades, Evelyn (Institut Hospital del Mar d'Investigacions Mèdiques) ; Sandoval, Juan (Institut d'Investigació Biomèdica de Bellvitge) ; Esteller, M. (Institució Catalana de Recerca i Estudis Avançats) ; Pujol, Ramón M.. (Hospital del Mar (Barcelona, Catalunya)) ; Hernández-Muñoz, Inmaculada (Institut Hospital del Mar d'Investigacions Mèdiques) ; Universitat Autònoma de Barcelona
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and frequently progresses from an actinic keratosis (AK), a sun-induced keratinocyte intraepithelial neoplasia (KIN). Epigenetic mechanisms involved in the phenomenon of progression from AK to cSCC remain to be elicited. [...]
2016 - 10.1186/s12943-016-0537-z
Molecular cancer, Vol. 15 (july 2016)  
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3.
20 p, 3.2 MB Expression of Melatonin and Dopamine D Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension / Reyes-Resina, Irene (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Awad Alkozi, Hanan (University Complutense of Madrid. Faculty of Optics and Optometry. Department of Biochemistry) ; del Ser Badia, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Sánchez-Naves, Juan (Institut d'Oftalmologia de les Illes Balears) ; Lillo, Jaume (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Jiménez, Jasmina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Pintor, Jesús (University Complutense of Madrid. Faculty of Optics and Optometry. Department of Biochemistry and Molecular Biology) ; Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ; Franco, Rafael (Universitat de Barcelona. Facultat de Química) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Background: Experiments in the late nineties showed an inverse relationship in the eye levels of melatonin and dopamine, thereby constituting an example of eye parameters that are prone to circadian variations. [...]
2020 - 10.3390/cells9010152
Cells, Vol. 9, Num. 1 (January 2020) , art. 152  
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4.
13 p, 2.9 MB BRAF mutations classes I, II, and III in NSCLC patients included in the SLLIP trial : The need for a new pre-clinical treatment rationale / Bracht, Jillian (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Karachaliou, Niki (Hospital Universitari Sagrat Cor. Institut Oncològic Rosell) ; Bivona, Trever (University of California. Department of Medicine) ; Lanman, Richard B. (Guardant Health) ; Faull, Iris (Guardant Health) ; Nagy, Rebecca J. (Guardant Health) ; Drozdowskyj, Ana (PIVOTAL SL) ; Berenguer, Jordi (Institut Universitari Quirón-Dexeus. Laboratori de Biologia Molecular) ; Fernandez-Bruno, Manuel (Hospital Universitario Sagrat Cor. Institut Oncològic Rosell) ; Molina-Vila, Miguel Ángel (Institut Universitari Quirón-Dexeus. Laboratori de Biologia Molecular) ; Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
BRAF V600 mutations have been found in 1-2% of non-small-cell lung cancer (NSCLC) patients, with Food and Drug Administration (FDA) approved treatment of dabrafenib plus trametinib and progression free survival (PFS) of 10. [...]
2019 - 10.3390/cancers11091381
Cancers, Vol. 11, Issue 9 (September 2019) , art. 1381  
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5.
15 p, 2.0 MB Basic Properties of the p38 Signaling Pathway in Response to Hyperosmotic Shock / Ben Messaoud, Nabil (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Katzarova, Ilina (Universitat Autònoma de Barcelona. Institut de Neurociències) ; López Blanco, José Manuel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Some properties of signaling systems, like ultrasensitivity, hysteresis (a form of biochemical memory), and all-or-none responses at a single cell level, are important to understand the regulation of irreversible processes. [...]
2015 - 10.1371/journal.pone.0135249
PloS one, Vol. 10, Num. 9 (September 2015) , p. 1-15  
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6.
16 p, 1.8 MB Interleukin-10 enhances the intestinal epithelial barrier in the presence of corticosteroids through p38 MAPK activity in Caco-2 monolayers : a possible mechanism for steroid responsiveness in ulcerative colitis / Lorén Moreno, Violeta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cabré i Gelada, Eduard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ojanguren, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Domènech, Eugeni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pedrosa Tapias, Elisabet (Institut Germans Trias i Pujol) ; Garcia-Jaraquemada, Arce (Institut Germans Trias i Pujol) ; Mañosa i Ciria, Míriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Manyé Almero, Josep (Institut Germans Trias i Pujol)
Glucocorticosteroids are the first line therapy for moderate-severe flare-ups of ulcerative colitis. Despite that, up to 60% of patients do not respond adequately to steroid treatment. Previously, we reported that low IL-10 mRNA levels in intestine are associated with a poor response to glucocorticoids in active Crohn's disease. [...]
2015 - 10.1371/journal.pone.0130921
PloS one, Vol. 10, No 6 (June 2015) , p. e0130921  
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7.
9 p, 1.4 MB Prostaglandin E2 Prevents Hyperosmolar-Induced Human Mast Cell Activation through Prostanoid Receptors EP2 and EP4 / Torres Atencio, Ivonne Marisol (Universidad de Panamá. Facultad de Medicina) ; Ainsua-Enrich, Erola (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Mora Pérez, Fernando de (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Picado Valles, César (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Martín Castillo, Margarita (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Background: Mast cells play a critical role in allergic and inflammatory diseases, including exercise-induced bronchoconstriction (EIB) in asthma. The mechanism underlying EIB is probably related to increased airway fluid osmolarity that activates mast cells to the release inflammatory mediators. [...]
2014 - 10.1371/journal.pone.0110870
PloS one, Vol. 9, Issue 10 (October 2014) , p.e110870  
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8.
14 p, 213.3 KB Effect of Roscovitine on nuclear maturation, MPF and MAP kinase activity and embryo development of prepubertal goat oocytes / Jiménez y de Macedo, Ana Raquel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Izquierdo Tugas, Ma. Dolors (Maria Dolors) (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Urdaneta Vargas, Aixa Efrailda (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Anguita Bustamante, Begoña (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Paramio, María Teresa (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
The low number of embryos obtained from IVM-IVF-IVC of prepubertal goat oocytes could be due to an incomplete cytoplasmic maturation. Roscovitine (ROS) inhibits MPF and MAP kinase activity and maintains the oocyte at Germinal Vesicle (GV) stage. [...]
2006 - 10.1016/j.theriogenology.2005.10.012
Theriogenology, Vol. 65, Num. 9 (2006) , p. 1769-1782  
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Documents de recerca 1 registres trobats  
1.
126 p, 3.6 MB New insights into the MAPK function in meiotic progression and the regulation of osmostress-induced apoptosis in Xenopus oocytes / Yue, Jicheng ; López Blanco, José Manuel, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
En el organismo modelo Xenopus laevis, los oocitos de estadio VI están parados indefinidamente en la profase (G2/M) de la meiosis I hasta que se produce una adecuada estimulación hormonal. Una red de regulación positiva alrededor de la cascada Mos/MEK/ERK asegura la maduración (GVBD) de los oocitos tras la estimulación con progesterona. [...]
In the model organism Xenopus laevis, oocytes at stage VI are standing in prophase (G2/M) of meiosis I indefinitely until proper hormone stimulation. A positive regulation network around the Mos/MEK/ERK cascade ensures the rapid maturation (GVBD) of the oocytes upon stimulation with progesterone. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2014  
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