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1.
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12 p, 3.8 MB |
Modular Evolution and Population Variability of Oikopleura dioica Metallothioneins
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Calatayud, Sara (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
García-Risco, Mario (Universitat Autònoma de Barcelona. Departament de Química) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Cañestro, Cristian (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Albalat, Ricard (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Chordate Oikopleura dioica probably is the fastest evolving metazoan reported so far, and thereby, a suitable system in which to explore the limits of evolutionary processes. For this reason, and in order to gain new insights on the evolution of protein modularity, we have investigated the organization, function and evolution of multi-modular metallothionein (MT) proteins in O. [...]
2021 -  10.3389/fcell.2021.702688
Frontiers in Cell and Developmental Biology, Vol. 9 (July 2021) , art. 702688
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2.
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14 p, 924.4 KB |
Tunicates Illuminate the Enigmatic Evolution of Chordate Metallothioneins by Gene Gains and Losses, Independent Modular Expansions, and Functional Convergences
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Calatayud, Sara (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
García-Risco, Mario (Universitat Autònoma de Barcelona. Departament de Química) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Cañestro, Cristian (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Albalat, Ricard (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
To investigate novel patterns and processes of protein evolution, we have focused in the metallothioneins (MTs), a singular group of metal-binding, cysteine-rich proteins that, due to their high degree of sequence diversity, still represents a "black hole" in Evolutionary Biology. [...]
2021 - 10.1093/molbev/msab184
Molecular biology and evolution, Vol. 38, Issue 10 (October 2021) , p. 4435-4448
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3.
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15 p, 1.8 MB |
Two Unconventional Metallothioneins in the Apple Snail Pomacea bridgesii Have Lost Their Metal Specificity during Adaptation to Freshwater Habitats
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García-Risco, Mario (Universitat Autònoma de Barcelona. Departament de Química) ;
Calatayud, Sara (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Niederwanger, Michael (University of Innsbruck. Institute of Zoology) ;
Albalat, Ricard (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Dallinger, Reinhard (University of Innsbruck. Institute of Zoology)
Metallothioneins (MTs) are a diverse group of proteins responsible for the control of metal homeostasis and detoxification. To investigate the impact that environmental conditions might have had on the metal-binding abilities of these proteins, we have characterized the MTs from the apple snail Pomacea bridgesii, a gastropod species belonging to the class of Caenogastropoda with an amphibious lifestyle facing diverse situations of metal bioavailability. [...]
2021 - 10.3390/ijms22010095
International journal of molecular sciences, Vol. 22, Issue 1 (January 2021) , art. 95
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4.
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15 p, 2.3 MB |
Biomphalaria glabrata metallothionein : Lacking metal specificity of the protein and missing gene upregulation suggest metal sequestration by exchange instead of through selective binding
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Niederwanger, Michael (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences Innsbruck) ;
Calatayud, Sara (Universitat de Barcelona. Departament de Biologia Evolutiva) ;
Zerbe, Oliver (University of Zürich. Department of Chemistry) ;
Atrian i Ventura, Sílvia (Universitat de Barcelona. Departament de Biologia Evolutiva) ;
Albalat, Ricard (Universitat de Barcelona. Departament de Biologia Evolutiva) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Dallinger, Reinhard (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences Innsbruck)
The wild-type metallothionein (MT) of the freshwater snail Biomphalaria glabrata and a natural allelic mutant of it in which a lysine residue was replaced by an asparagine residue, were recombinantly expressed and analyzed for their metal-binding features with respect to Cd, Zn and Cu, applying spectroscopic and mass-spectrometric methods. [...]
2017 - 10.3390/ijms18071457
International journal of molecular sciences, Vol. 18, Num. 7 (July 2017) , art. 1457
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5.
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16 p, 2.2 MB |
Hints for metal-preference protein sequence determinants : different metal binding features of the five Tetrahymena thermophila metallothioneins
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Espart Herrero, Anna (Universitat de Barcelona. Departament de Genètica) ;
Marín, Maribel (Universitat Autònoma de Barcelona. Departament de Química) ;
Gil-Moreno, Selene (Universitat Autònoma de Barcelona. Departament de Química) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Amaro Umbert, Francesc (Universidad Complutense de Madrid. Departamento de Microbiología III) ;
Martín-González, Ana (Universidad Complutense de Madrid. Departamento de Microbiología III) ;
Gutiérrez Fernández, Juan Carlos (Universidad Complutense de Madrid. Departamento de Microbiología III) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Atrian i Ventura, Sílvia (Universitat de Barcelona. Departament de Genètica)
The metal binding preference of metallothioneins (MTs) groups them in two extreme subsets, the Zn/Cd- and the Cu-thioneins. Ciliates harbor the largest MT gene/protein family reported so far, including 5 paralogs that exhibit relatively low sequence similarity, excepting MTT2 and MTT4. [...]
2015 - 10.7150/ijbs.11060
International journal of biological sciences, Vol. 11 (March 2015) , p. 456-471
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6.
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16 p, 2.3 MB |
Analysis of metal-binding features of the wild type and two domain-truncated mutant variants of Littorina littorea metallothionein reveals its cd-specific character
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Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Jiménez Martí, Elena (Universitat de Barcelona. Departament de Genètica) ;
Niederwanger, Michael (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences) ;
Gil-Moreno, Selene (Universitat Autònoma de Barcelona. Departament de Química) ;
Zerbe, Oliver (University of Zurich. Institute of Organic Chemistry) ;
Atrian i Ventura, Sílvia (Universitat de Barcelona. Departament de Genètica) ;
Dallinger, Reinhard (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química)
After the resolution of the 3D structure of the Cd9-aggregate of the Littorina littorea metallothionein (MT), we report here a detailed analysis of the metal binding capabilities of the wild type MT, LlwtMT, and of two truncated mutants lacking either the N-terminal domain, Lltr2MT, or both the N-terminal domain, plus four extra flanking residues (SSVF), Lltr1MT. [...]
2017 - 10.3390/ijms18071452
International journal of molecular sciences, Vol. 18 Núm. 7 (july 2017) , p. 1452
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12 p, 5.5 MB |
Influence of transgenic metallothionein-1 on gliosis, CA1 neuronal loss, and brain metal levels of the Tg2576 mouse model of Alzheimer's disease
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Comes, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Manso Sanz, Yasmina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Escrig, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Fernandez-Gayol, Olaya (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Sanchis Tortosa, Paula (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Molinero Egea, María Amalia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Giralt, Mercedes (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Carrasco, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The mouse model of Alzheimer's disease (AD), Tg2576 mice (APP), has provided valuable information, such as the role of the metallothionein (MT) family in their behavioral and amyloidosis phenotypes. In this study, we further characterize the role of MT-1 by crossing Mt1-overexpressing mice with Tg2576 mice (APPTgMT). [...]
2017 - 10.3390/ijms18020251
International journal of molecular sciences, Vol. 18, issue 2 (Feb. 2017) , art. 251
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8.
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13 p, 1.3 MB |
Does Variation of the Inter-Domain Linker Sequence Modulate the Metal Binding Behaviour of Helix pomatia Cd-Metallothionein?
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Gil-Moreno, Selene (Universitat Autònoma de Barcelona. Departament de Química) ;
Jiménez Martí, Elena (Universitat de Barcelona. Departament de Genètica) ;
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química) ;
Zerbe, Oliver (University of Zurich. Institute of Organic Chemistry) ;
Dallinger, Reinhard (University of Innsbruck. Institute of Zoology and Center of Molecular Biosciences) ;
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Atrian i Ventura, Sílvia (Universitat de Barcelona. Departament de Genètica)
Snail metallothioneins (MTs) constitute an ideal model to study structure/function relationships in these metal-binding polypeptides. Helix pomatia harbours three MT isoforms: the highly specific CdMT and CuMT, and an unspecific Cd/CuMT, which represent paralogous proteins with extremely different metal binding preferences while sharing high sequence similarity. [...]
2016 - 10.3390/ijms17010006
International journal of molecular sciences, Vol. 17 Núm. 6 (2016) , p. 1-13
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