1.
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15 p, 4.5 MB |
Down-regulation of tomato STEROL GLYCOSYLTRANSFERASE 1 perturbs plant development and facilitates viroid infection
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Cisneros, Adriana E (Institut de Biologia Molecular i Cel·lular de Plantes) ;
Lisón, Purificación (Institut de Biologia Molecular i Cel·lular de Plantes) ;
Campos, Laura (Institut de Biologia Molecular i Cel·lular de Plantes) ;
López-Tubau, Joan Manel (Centre de Recerca en Agrigenòmica) ;
Altabella Artigas, Teresa (Centre de Recerca en Agrigenòmica) ;
Daròs, José-Antonio (Centre de Recerca en Agrigenòmica) ;
Carbonell, Alberto (Institut de Biologia Molecular i Cel·lular de Plantes)
Potato spindle tuber viroid (PSTVd) is a plant pathogen naturally infecting economically important crops such as tomato (Solanum lycopersicum). Here, we aimed to engineer tomato plants highly resistant to PSTVd and developed several S. [...]
2022 - 10.1093/jxb/erac361
Journal of experimental botany, Vol. 74, Issue 5 (March 2022) , p. 1564-1578
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2.
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9 p, 4.2 MB |
MiR-125b downregulates macrophage scavenger receptor type B1 and reverse cholesterol transport
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Hueso, Miguel (Institut d'Investigació Biomèdica de Bellvitge) ;
Griñán, Raquel (Institut d'Investigació Biomèdica Sant Pau) ;
Mallen, Adrián (Institut d'Investigació Biomèdica de Bellvitge) ;
Navarro, Estanislao (Institut d'Investigació Biomèdica de Bellvitge) ;
Purqueras, Elvira (Institut d'Investigació Biomèdica de Bellvitge) ;
Gomá, Montse (Institut d'Investigació Biomèdica de Bellvitge) ;
Sbraga, Fabritzio (Institut d'Investigació Biomèdica de Bellvitge) ;
Blasco-Lucas, Arnau (Hospital Universitari de Bellvitge) ;
Revilla, Giovanna (Institut d'Investigació Biomèdica Sant Pau) ;
Santos, David (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Canyelles, Marina (Institut d'Investigació Biomèdica Sant Pau) ;
Julve i Gil, Josep (Institut d'Investigació Biomèdica Sant Pau) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Rotllan, Noemi (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Objective: To determine whether miR-125b regulates cholesterol efflux in vivo and in vitro through the regulation of scavenger receptor type B1 (SR-B1). Approach and results: We demonstrated that miR-125b is up-regulated in the human aortas of patients with CAD and is located in macrophages and vascular smooth muscle cells (VSMCs). [...]
2022 - 10.1016/j.biopha.2021.112596
Biomedicine & pharmacotherapy, Vol. 146 (february 2022) , p. 112596
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3.
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27 p, 6.2 MB |
Immunoregulatory Biomarkers of the Remission Phase in Type 1 Diabetes : miR-30d-5p Modulates PD-1 Expression and Regulatory T Cell Expansion
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Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Armengol, Maria Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alcalde, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Català, Martí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sunye, Sergi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valls, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corripio, Raquel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The partial remission (PR) phase of type 1 diabetes (T1D) is an underexplored period characterized by endogenous insulin production and downmodulated autoimmunity. To comprehend the mechanisms behind this transitory phase and develop precision medicine strategies, biomarker discovery and patient stratification are unmet needs. [...]
2023 - 10.3390/ncrna9020017
Non-Coding RNA, Vol. 9 (february 2023)
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4.
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46 p, 1.5 MB |
Modeling microRNA-driven post-transcriptional regulation using exon-intron split analysis in pigs
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Mármol-Sánchez, Emilio (Centre de Recerca en Agrigenòmica) ;
Cirera, Susanna (University of Copenhagen. Department of Veterinary and Animal Sciences) ;
Zingaretti, Laura M. (Universidad Nacional de Villa María) ;
Jacobsen, Mette Juul (University of Copenhagen. Department of Veterinary and Animal Sciences) ;
Ramayo-Caldas, Yuliaxis (Institut de Recerca i Tecnologia Agroalimentàries) ;
Jørgensen, Claus B. (University of Copenhagen. Department of Veterinary and Animal Sciences) ;
Fredholm, Merete (University of Copenhagen. Department of Veterinary and Animal Sciences) ;
Cardoso, Tainã Figueiredo (Institut de Recerca i Tecnologia Agroalimentàries) ;
Quintanilla, Raquel (Institut de Recerca i Tecnologia Agroalimentàries) ;
Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
The contribution of microRNAs (miRNAs) to mRNA post-transcriptional regulation has often been explored by the post hoc selection of downregulated genes and determining whether they harbor binding sites for miRNAs of interest. [...]
2022 - 10.1111/age.13238
Animal Genetics, Vol. 53, Issue 5 (October 2022) , p. 613-626
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5.
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10 p, 1.1 MB |
Specific Plasma MicroRNA Signatures Underlying the Clinical Outcomes of Hepatitis E Virus Infection
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Costafreda Salvany, Maria Isabel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sauleda, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Rico, Angie (Banc de Sang i Teixits de Catalunya) ;
Llorens-Revull, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guix, Susana (Universitat de Barcelona) ;
Pintó, Rosa M. (Universitat de Barcelona) ;
Bosch, Albert (Universitat de Barcelona) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Piron, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bes, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
The pathogenic mechanisms determining the diverse clinical outcomes of HEV infection (e. g. , self-limiting versus chronic or symptomatic versus asymptomatic) are not yet understood. Because specific microRNA signatures during viral infection inform the cellular processes involved in virus replication and pathogenesis, we investigated plasma microRNA profiles in 44 subjects, including patients with symptomatic acute (AHE, n = 7) and chronic (CHE, n = 6) hepatitis E, blood donors with asymptomatic infection (HEV BDs, n = 9), and anti-HEV IgG + IgM − (exposed BDs, n = 10) and anti-HEV IgG − IgM − (naive BDs, n = 12) healthy blood donors. [...]
2023 - 10.1128/spectrum.04664-22
Microbiology Spectrum, Vol. 11 (january 2023)
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6.
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13 p, 1.9 MB |
A study of differential microRNA expression profile in migraine : the microMIG exploratory study
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Gallardo, Víctor J.. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gómez-Galván, J. B. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Asskour, L. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torres-Ferrús, Marta (Hospital Universitari Vall d'Hebron) ;
Alpuente, Alicia (Hospital Universitari Vall d'Hebron) ;
Caronna, Edoardo (Hospital Universitari Vall d'Hebron) ;
Pozo-Rosich, Patricia (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Several studies have described potential microRNA (miRNA) biomarkers associated with migraine, but studies are scarcely reproducible primarily due to the heterogeneous variability of participants. Increasing evidence shows that disease-related intrinsic factors together with lifestyle (environmental factors), influence epigenetic mechanisms and in turn, diseases. [...]
2023 - 10.1186/s10194-023-01542-z
Journal of headache and pain, Vol. 24 (february 2023)
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7.
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6 p, 292.0 KB |
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis
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Garcia Garcia de Paredes, Ana (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Villanueva, Càndid (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco, Carolina (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Genescà Ferrer, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Manicardi, Nicolo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Garcia-Pagan, Juan Carlos (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Calleja, Jose Luis (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Aracil, Carlos (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Morillas Cunill, Rosa Ma (Universitat Autònoma de Barcelona) ;
Poca Sans, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Peñas, Beatriz (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Augustin Recio, Salvador (Hospital Universitari Vall d'Hebron) ;
Abraldes, Juan G. (University of Alberta) ;
Alvarado-Tapias, Edilmar (Institut d'Investigació Biomèdica Sant Pau) ;
Royo, Félix (Exosomes Laboratory. Center for Cooperative Research in Biosciencies (CIC bioGUNE). Basque Research and Technology Alliance (BRTA)) ;
García-Bermejo, Mª Laura (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Falcon-Perez, Juan Manuel (Exosomes Laboratory. Center for Cooperative Research in Biosciencies (CIC bioGUNE). Basque Research and Technology Alliance (BRTA)) ;
Bañares, Rafael (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Bosch, Jaime (Department of Biomedical Research and University Clinic for Visceral Medicine and Surgery. Inselspital) ;
Gracia-Sancho, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Albillos, Agustín (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Universitat Autònoma de Barcelona
Background & Aims: Treatment with non-selective beta-blockers (NSBBs) reduces the risk of ascites, which is the most common decompensating event in cirrhosis. This study aimed to assess the ability of a serum microRNA (miRNA) signature to predict ascites formation and the hemodynamic response to NSBBs in compensated cirrhosis. [...]
2021 - 10.1016/j.jhepr.2021.100368
JHEP Reports, Vol. 3 Núm. 6 (december 2021) , p. 100368
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8.
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15 p, 2.3 MB |
Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans
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Duecker, Ruth P.. (Goethe University) ;
de Mir-Messa, Inés (Hospital Universitari Vall d'Hebron) ;
Jerkic, Silvija-Pera (Goethe University) ;
Kochems, Annalena (Goethe University) ;
Gottwald, Gabriele (Goethe University) ;
Moreno Galdó, Antonio (Instituto de Salud Carlos III) ;
Rosewich, Martin (Goethe University) ;
Gronau, Lucia (Goethe University) ;
Zielen, Stefan (Goethe University) ;
Geburtig-Chiocchetti, Andreas (Goethe University) ;
Kreyenberg, Hermann (Goethe University) ;
Schubert, Ralf (Goethe University) ;
Universitat Autònoma de Barcelona
Post-infectious bronchiolitis obliterans (PiBO) is a rare, chronic disease initiated by severe infection and followed by perpetuating inflammation and obliteration of the small airways. MicroRNAs (miRNAs) have been proposed to play a central role as epigenetic regulators, which control resolution and prevent the uncontrolled progress of inflammation. [...]
2022 - 10.1002/cti2.1376
Clinical & Translational Immunology, Vol. 11 (february 2022)
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9.
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14 p, 1.4 MB |
A novel Transposable element-derived microRNA participates in plant immunity to rice blast disease
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Campo, Sonia (Centre de Recerca en Agrigenòmica) ;
Sánchez-Sanuy, Ferran (Centre de Recerca en Agrigenòmica) ;
Gómez-Ariza, Jorge (Centre de Recerca en Agrigenòmica) ;
Baldrich, Patricia (Centre de Recerca en Agrigenòmica) ;
Campos-Soriano, Lidia (Centre de Recerca en Agrigenòmica) ;
Soto-Suárez, Mauricio (Centre de Recerca en Agrigenòmica) ;
San Segundo, Blanca (Centre de Recerca en Agrigenòmica)
MicroRNAs (miRNAs) are small non-coding RNAs that direct post-transcriptional gene silencing in plant development and stress responses through cleavage or translational repression of target mRNAs. Here, we report the identification and functional characterization of a new member of the miR812 family in rice (named as miR812w) involved in disease resistance. [...]
2021 - 10.1111/pbi.13592
Plant Biotechnology Journal, Vol. 19, Issue 9 (September 2021) , p. 1798-1811
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